Download PDF
CC BY 4.0 · Journal of Child Science 2023; 13(01): e12-e19
DOI: 10.1055/s-0043-1764341
Original Article

The Outcomes of Treatment in Infants with Short Bowel Syndrome

Quynh Anh Tran
1   Vietnam National Children's Hospital, Hanoi, Vietnam
,
Tam Thi Ngo
2   Faculty of Health Sciences, Thang Long University, Hanoi, Vietnam
,
Tran Thi Ngoc Nguyen
1   Vietnam National Children's Hospital, Hanoi, Vietnam
,
Son Thanh Le
3   Vietnam Military Medical Academic, Hanoi, Vietnam
,
Thanh Chi Ho
3   Vietnam Military Medical Academic, Hanoi, Vietnam
,
Thao Khac Thai
3   Vietnam Military Medical Academic, Hanoi, Vietnam
,
Hung Tran
1   Vietnam National Children's Hospital, Hanoi, Vietnam
› Author Affiliations
› Further Information
Also available at
   Permissions and Reprints

Abstract

Objective We reviewed 50 infant cases with short bowel syndrome (SBS) to examine the treatment outcome of SBS management in a tertiary hospital in Vietnam.

Material and Methods A case series was performed at the National Children's Hospital, Hanoi, Vietnam. A total of 50 cases with SBS were reviewed. Clinical and laboratory characteristics before and after treatment were collected.

Results The most common cause of SBS was necrotizing enterocolitis. Common clinical symptoms included watery stools, dehydration, and malnutrition. After treatment, the patient's weight, albumin, and prothrombin improved markedly. There are 72% of children with good or fair treatment results. The rate of sepsis was high (18%). There was one case with complications of catheter infection and one case of liver failure. Three children died during treatment, one died from septic shock and multiple organ failure, and two died from respiratory failure.

Conclusion This study showed promising treatment outcomes in pediatrics.

Keywords

short bowel syndrome - clinical - subclinical - results

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or National Research Committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.


This study was also approved by The Institutional Review Board of the National Children's Hospital (Code: 1424/BVNTW-VNCSKTE).


Informed Consent

All data were collected anonymously, and patient consent was not required.




Publication History

Received: 03 December 2022

Accepted: 02 February 2023

Article published online:
17 March 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Chandra R, Kesavan A. Current treatment paradigms in pediatric short bowel syndrome. Clin J Gastroenterol 2018; 11 (02) 103-112
    CrossrefPubMedGoogle Scholar
  • 2 Merritt RJ, Cohran V, Raphael BP. et al; Nutrition Committee of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Intestinal rehabilitation programs in the management of pediatric intestinal failure and short bowel syndrome. J Pediatr Gastroenterol Nutr 2017; 65 (05) 588-596
    CrossrefPubMedGoogle Scholar
  • 3 Feng H, Zhang T, Yan W. et al. Micronutrient deficiencies in pediatric short bowel syndrome: a 10-year review from an intestinal rehabilitation center in China. Pediatr Surg Int 2020; 36 (12) 1481-1487
    CrossrefPubMedGoogle Scholar
  • 4 Lauro A, Lacaille F. Short bowel syndrome in children and adults: from rehabilitation to transplantation. Expert Rev Gastroenterol Hepatol 2019; 13 (01) 55-70
    CrossrefPubMedGoogle Scholar
  • 5 Nayyar N, Mazariegos G, Ranganathan S. et al. Pediatric small bowel transplantation. Semin Pediatr Surg 2010; 19 (01) 68-77
    CrossrefPubMedGoogle Scholar
  • 6 Coletta R, Khalil BA, Morabito A. Short bowel syndrome in children: surgical and medical perspectives. Semin Pediatr Surg 2014; 23 (05) 291-297
    CrossrefPubMedGoogle Scholar
  • 7 Torres C, Sudan D, Vanderhoof J. et al. Role of an intestinal rehabilitation program in the treatment of advanced intestinal failure. J Pediatr Gastroenterol Nutr 2007; 45 (02) 204-212
    CrossrefPubMedGoogle Scholar
  • 8 WHO Multicentre Growth Reference Study Group. WHO Child Growth Standards based on length/height, weight and age. Acta Paediatr Suppl 2006; 450: 76-85
    CrossrefPubMedGoogle Scholar
  • 9 Radlović N, Leković Z, Vuletić B, Radlović V, Simić D. Acute diarrhea in children. Srp Arh Celok Lek 2015; 143 (11-12): 755-762
    CrossrefPubMedGoogle Scholar
  • 10 Gennari FJ. Hypokalemia. N Engl J Med 1998; 339 (07) 451-458
    CrossrefPubMedGoogle Scholar
  • 11 Nadler JL, Rude RK. Disorders of magnesium metabolism. Endocrinol Metab Clin North Am 1995; 24 (03) 623-641
    CrossrefPubMedGoogle Scholar
  • 12 Salvia G, Guarino A, Terrin G. et al; Working Group on Neonatal Gastroenterology of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition. Neonatal onset intestinal failure: an Italian Multicenter Study. J Pediatr 2008; 153 (05) 674-676 , 676.e1–676.e2
    CrossrefPubMedGoogle Scholar
  • 13 Sala D, Chomto S, Hill S. Long-term outcomes of short bowel syndrome requiring long-term/home intravenous nutrition compared in children with gastroschisis and those with volvulus. Transplant Proc 2010; 42 (01) 5-8
    CrossrefPubMedGoogle Scholar
  • 14 Wu J, Tang Q, Feng Y. et al. Nutrition assessment in children with short bowel syndrome weaned off parenteral nutrition: a long-term follow-up study. J Pediatr Surg 2007; 42 (08) 1372-1376
    CrossrefPubMedGoogle Scholar
  • 15 Andorsky DJ, Lund DP, Lillehei CW. et al. Nutritional and other postoperative management of neonates with short bowel syndrome correlates with clinical outcomes. J Pediatr 2001; 139 (01) 27-33
    CrossrefPubMedGoogle Scholar
  • 16 Vantini I, Benini L, Bonfante F. et al. Survival rate and prognostic factors in patients with intestinal failure. Dig Liver Dis 2004; 36 (01) 46-55
    CrossrefPubMedGoogle Scholar