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DOI: 10.1055/s-0043-1763505
Moving Beyond Movement: Diagnosing Functional Movement Disorder
Funding This work was supported by an anonymous donation to the Toronto Western Hospital Movement Disorders Clinic.Abstract
Functional movement disorder (FMD) is a complex neuropsychiatric syndrome, encompassing abnormal movements and weakness, and is a common cause of potentially disabling neurological symptoms. It is vital to recognize that FMD is a syndrome, with nonmotor manifestations negatively affecting a patient's quality of life. This review highlights a diagnostic algorithm, where a history suggestive of FMD is combined with the presence of positive signs on examination and appropriate investigations to make the diagnosis. Positive signs indicate internal inconsistency such as variability and distractibility, and clinical findings that are incongruent with other known neurological disease. Importantly, the clinical assessment acts as the first opportunity to allow patients to understand FMD as the cause for their symptoms. Accurate and early diagnosis of FMD is necessary given that it is a treatable and potentially reversible cause of disability, with significant risk of iatrogenic harm associated with misdiagnosis.
Keywords
functional neurological disorder - functional movement disorder - diagnosis - pathophysiology - positive signsNote
This manuscript complies with all instructions to authors.
This manuscript is an original work and has not been published elsewhere and is not under consideration by another journal. This article does not contain clinical studies or patient data.
Ethical Standards
This article does not contain clinical studies or patient data.
Author Contributions
G.S.G.: Conceptualization; investigation; writing—original draft. S.C.L.: Conceptualization; writing—review and editing.
Publikationsverlauf
Artikel online veröffentlicht:
09. März 2023
© 2023. Thieme. All rights reserved.
Thieme Medical Publishers, Inc.
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References
- 1 Lidstone SC, Costa-Parke M, Robinson EJ, Ercoli T, Stone J. FMD GAP Study Group. Functional movement disorder gender, age and phenotype study: a systematic review and individual patient meta-analysis of 4905 cases. J Neurol Neurosurg Psychiatry 2022; 93 (06) 609-616
- 2 Hallett M. Psychogenic movement disorders: a crisis for neurology. Curr Neurol Neurosci Rep 2006; 6 (04) 269-271
- 3 Gilmour GS, Nielsen G, Teodoro T. et al. Management of functional neurological disorder. J Neurol 2020; 267 (07) 2164-2172
- 4 Goldstein LH, Mellers JDC. Psychologic treatment of functional neurologic disorders. Handb Clin Neurol 2016; 139: 571-583
- 5 Nielsen G. Physical treatment of functional neurologic disorders. In: Hallett M, Stone J, Carson A. eds. Functional Neurologic Disorders. Vol 139. Amsterdam: Elsevier; 2016: 555-569
- 6 Nielsen G, Stone J, Matthews A. et al. Physiotherapy for functional motor disorders: a consensus recommendation. J Neurol Neurosurg Psychiatry 2015; 86 (10) 1113-1119
- 7 Nicholson C, Edwards MJ, Carson AJ. et al. Occupational therapy consensus recommendations for functional neurological disorder. J Neurol Neurosurg Psychiatry 2020; 91 (10) 1037-1045
- 8 Baker J, Barnett C, Cavalli L. et al. Management of functional communication, swallowing, cough and related disorders: consensus recommendations for speech and language therapy. J Neurol Neurosurg Psychiatry 2021; 92 (10) 1112-1125
- 9 Butler M, Shipston-Sharman O, Seynaeve M. et al. International online survey of 1048 individuals with functional neurological disorder. Eur J Neurol 2021; 28 (11) 3591-3602
- 10 Forejtová Z, Serranová T, Sieger T. et al. The complex syndrome of functional neurological disorder. Psychol Med 2022; 7: 1-11
- 11 Aybek S, Lidstone SC, Nielsen G. et al. What is the role of a specialist assessment clinic for FND? Lessons from three national referral centers. J Neuropsychiatry Clin Neurosci 2020; 32 (01) 79-84
- 12 Tinazzi M, Morgante F, Marcuzzo E. et al. Clinical correlates of functional motor disorders: an Italian multicenter study. Mov Disord Clin Pract (Hoboken) 2020; 7 (08) 920-929
- 13 Věchetová G, Slovák M, Kemlink D. et al. The impact of non-motor symptoms on the health-related quality of life in patients with functional movement disorders. J Psychosom Res 2018; 115 (September): 32-37
- 14 Tinazzi M, Geroin C, Marcuzzo E. et al. Functional motor phenotypes: to lump or to split?. J Neurol 2021; 268 (12) 4737-4743
- 15 Carson A, Lehn A. Epidemiology. Handb Clin Neurol 2016; 139: 47-60
- 16 Carson AJ, Ringbauer B, Stone J, McKenzie L, Warlow C, Sharpe M. Do medically unexplained symptoms matter? A prospective cohort study of 300 new referrals to neurology outpatient clinics. J Neurol Neurosurg Psychiatry 2000; 68 (02) 207-210
- 17 Popkirov S, Nicholson TR, Bloem BR. et al. Hiding in plain sight: functional neurological disorders in the news. J Neuropsychiatry Clin Neurosci 2019; 31 (04) 361-367
- 18 Stone J, Warlow C, Sharpe M. The symptom of functional weakness: a controlled study of 107 patients. Brain 2010; 133 (Pt 5): 1537-1551
- 19 Binzer M, Andersen PM, Kullgren G. Clinical characteristics of patients with motor disability due to conversion disorder: a prospective control group study. J Neurol Neurosurg Psychiatry 1997; 63 (01) 83-88
- 20 Stefánsson JG, Messina JA, Meyerowitz S. Hysterical neurosis, conversion type: clinical and epidemiological considerations. Acta Psychiatr Scand 1976; 53 (02) 119-138
- 21 Stevens DL. Neurology in Gloucestershire: the clinical workload of an English neurologist. J Neurol Neurosurg Psychiatry 1989; 52 (04) 439-446
- 22 Stone J, Carson A, Duncan R. et al. Who is referred to neurology clinics?–the diagnoses made in 3781 new patients. Clin Neurol Neurosurg 2010; 112 (09) 747-751
- 23 Stone J, Carson A, Duncan R. et al. Symptoms ‘unexplained by organic disease’ in 1144 new neurology out-patients: how often does the diagnosis change at follow-up?. Brain 2009; 132 (Pt 10): 2878-2888
- 24 Carson A, Stone J, Hibberd C. et al. Disability, distress and unemployment in neurology outpatients with symptoms ‘unexplained by organic disease’. J Neurol Neurosurg Psychiatry 2011; 82 (07) 810-813
- 25 Stephen CD, Fung V, Lungu CI, Espay AJ. Assessment of emergency department and inpatient use and costs in adult and pediatric functional neurological disorders. JAMA Neurol 2021; 78 (01) 88-101
- 26 Tinazzi M, Gandolfi M, Landi S, Leardini C. Economic costs of delayed diagnosis of functional motor disorders: preliminary results from a cohort of patients of a specialized clinic. Front Neurol 2021; 12 (December): 786126
- 27 Perez DL, Aybek S, Popkirov S. et al; (On behalf of the American Neuropsychiatric Association Committee for Research. A review and expert opinion on the neuropsychiatric assessment of motor functional neurological disorders. J Neuropsychiatry Clin Neurosci 2021; 33 (01) 14-26
- 28 American Psychiatric Association; Diagnostic and Statistical Manual of Mental Disorders. 5th ed.;. 2013
- 29 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. TR.; 2022. Available at: https://doi.org/10.1176/appi.books.9780890425787
- 30 Ludwig L, Pasman JA, Nicholson T. et al. Stressful life events and maltreatment in conversion (functional neurological) disorder: systematic review and meta-analysis of case-control studies. Lancet Psychiatry 2018; 5 (04) 307-320
- 31 Roelofs K, Keijsers GPJ, Hoogduin KAL, Näring GWB, Moene FC. Childhood abuse in patients with conversion disorder. Am J Psychiatry 2002; 159 (11) 1908-1913
- 32 Kletenik I, Holden SK, Sillau SH. et al. Gender disparity and abuse in functional movement disorders: a multi-center case-control study. J Neurol 2022; 269 (06) 3258-3263
- 33 Kletenik I, Sillau SH, Isfahani SA, LaFaver K, Hallett M, Berman BD. Gender as a risk factor for functional movement disorders: the role of sexual abuse. Mov Disord Clin Pract (Hoboken) 2019; 7 (02) 177-181
- 34 Hallett M, Aybek S, Dworetzky BA, McWhirter L, Staab JP, Stone J. Functional neurological disorder: new subtypes and shared mechanisms. Lancet Neurol 2022; 21 (06) 537-550
- 35 Kranick S, Ekanayake V, Martinez V, Ameli R, Hallett M, Voon V. Psychopathology and psychogenic movement disorders. Mov Disord 2011; 26 (10) 1844-1850
- 36 Spagnolo PA, Norato G, Maurer CW. et al. Effects of TPH2 gene variation and childhood trauma on the clinical and circuit-level phenotype of functional movement disorders. J Neurol Neurosurg Psychiatry 2020; 91 (08) 814-821
- 37 Tinazzi M, Geroin C, Erro R. et al. Functional motor disorders associated with other neurological diseases: beyond the boundaries of “organic” neurology. Eur J Neurol 2021; 28 (05) 1752-1758
- 38 Voon V, Gallea C, Hattori N, Bruno M, Ekanayake V, Hallett M. The involuntary nature of conversion disorder. Neurology 2010; 74 (03) 223-228
- 39 Edwards MJ, Adams RA, Brown H, Pareés I, Friston KJ. A Bayesian account of ‘hysteria’. Brain 2012; 135 (Pt 11): 3495-3512
- 40 Huys AML, Haggard P, Bhatia KP, Edwards MJ. Misdirected attentional focus in functional tremor. Brain 2021; 144 (11) 3436-3450
- 41 Pareés I, Saifee TA, Kassavetis P. et al. Believing is perceiving: mismatch between self-report and actigraphy in psychogenic tremor. Brain 2012; 135 (Pt 1): 117-123
- 42 Lidstone SC, Araújo R, Stone J, Bloem BR. Ten myths about functional neurological disorder. Eur J Neurol 2020; 27 (11) e62-e64
- 43 Lidstone SC, Nassif W, Juncos J, Factor SA, Lang AE. Diagnosing functional neurological disorder: seeing the whole picture. CNS Spectr 2020; 9: 1-8
- 44 Carson A, Hallett M, Stone J. Assessment of patients with functional neurologic disorders. Handb Clin Neurol 2016; 139: 169-188
- 45 Gilmour GS, Lidstone SC, Lang AE. The diagnosis of functional movement disorder. Pract Neurol 2022; (March/April): 40-53
- 46 Gupta A, Lang AE. Psychogenic movement disorders. Curr Opin Neurol 2009; 22 (04) 430-436
- 47 Aybek S, Perez DL. Diagnosis and management of functional neurological disorder. BMJ 2022; 376: o64
- 48 Espay AJ, Aybek S, Carson A. et al. Current concepts in diagnosis and treatment of functional neurological disorders. JAMA Neurol 2018; 75 (09) 1132-1141
- 49 Baizabal-Carvallo JF, Jankovic J. Distinguishing features of psychogenic (functional) versus organic hemifacial spasm. J Neurol 2017; 264 (02) 359-363
- 50 Laub HN, Dwivedi AK, Revilla FJ, Duker AP, Pecina-Jacob C, Espay AJ. Diagnostic performance of the “Huffing and Puffing” sign in functional (psychogenic) movement disorders. Mov Disord Clin Pract (Hoboken) 2015; 2 (01) 29-32
- 51 Daum C, Gheorghita F, Spatola M. et al. Interobserver agreement and validity of bedside ‘positive signs’ for functional weakness, sensory and gait disorders in conversion disorder: a pilot study. J Neurol Neurosurg Psychiatry 2015; 86 (04) 425-430
- 52 Baizabal-Carvallo JF, Jankovic J. Functional (psychogenic) stereotypies. J Neurol 2017; 264 (07) 1482-1487
- 53 Aboud O, Al-Salaimeh A, Kumar Raina S, Sahaya K, Hinduja A. Positive clinical signs in neurological diseases - an observational study. J Clin Neurosci 2019; 59: 141-145
- 54 Hallett M. Neurophysiologic studies of functional neurologic disorders. Handb Clin Neurol 2016; 139: 61-71
- 55 Lang AE. Phenomenology of psychogenic movement disorders. In: Hallet M, Lang AE, Jankovic J. et al., eds. Psychogenic Movement Disorders and Other Coversion Disorders. Cambridge, UK: Cambridge University Press; 2011: 6-13
- 56 van der Salm SMA, Erro R, Cordivari C. et al. Propriospinal myoclonus: clinical reappraisal and review of literature. Neurology 2014; 83 (20) 1862-1870
- 57 Ambar Akkaoui M, Geoffroy PA, Roze E, Degos B, Garcin B. Functional motor symptoms in parkinson's disease and functional parkinsonism: a systematic review. J Neuropsychiatry Clin Neurosci 2020; 32 (01) 4-13
- 58 Ganos C, Edwards MJ, Bhatia KP. The phenomenology of functional (psychogenic) dystonia. Mov Disord Clin Pract (Hoboken) 2014; 1 (01) 36-44
- 59 Schrag A, Trimble M, Quinn N, Bhatia K. The syndrome of fixed dystonia: an evaluation of 103 patients. Brain 2004; 127 (Pt 10): 2360-2372
- 60 Stamey W, Jankovic J. The other Babinski sign in hemifacial spasm. Neurology 2007; 69 (04) 402-404
- 61 Fasano A, Valadas A, Bhatia KP. et al. Psychogenic facial movement disorders: clinical features and associated conditions. Mov Disord 2012; 27 (12) 1544-1551
- 62 Mishra A, Pandey S. Cranial functional movement disorders: a case series with literature review. Tremor Other Hyperkinet Mov (N Y) 2020; 10 (01) 33
- 63 Ganos C, Aguirregomozcorta M, Batla A. et al. Psychogenic paroxysmal movement disorders–clinical features and diagnostic clues. Parkinsonism Relat Disord 2014; 20 (01) 41-46
- 64 Demartini B, Ricciardi L, Parees I, Ganos C, Bhatia KP, Edwards MJ. A positive diagnosis of functional (psychogenic) tics. Eur J Neurol 2015; 22 (03) 527-e36
- 65 Bhatia KP, Bhatt MH, Marsden CD. The causalgia-dystonia syndrome. Brain 1993; 116 (Pt 4): 843-851
- 66 Fasano A, Tinazzi M. Functional facial and tongue movement disorders. Handb Clin Neurol 2016; 139: 353-365
- 67 Roper LS, Saifee TA, Parees I, Rickards H, Edwards MJ. How to use the entrainment test in the diagnosis of functional tremor. Pract Neurol 2013; 13 (06) 396-398
- 68 Fahn S, Williams DT. Psychogenic dystonia. Adv Neurol 1988; 50: 431-455
- 69 Walzl D, Solomon AJ, Stone J. Functional neurological disorder and multiple sclerosis: a systematic review of misdiagnosis and clinical overlap. J Neurol 2022; 269 (02) 654-663
- 70 Wangaryattawanich P, Rutman AM, Petcharunpaisan S, Mossa-Basha M. Incidental findings on brain magnetic resonance imaging (MRI) in adults: a review of imaging spectrum, clinical significance, and management. Br J Radiol 2022; (January): 1-13
- 71 Katzman GL, Dagher AP, Patrona NJ. Incidental findings on brain magnetic resonance imaging from 1,000 asymptomatic volunteers. Evid Based Eye Care 2000; 1 (02) 114-115
- 72 Li Y, Thompson WK, Reuter C. et al; ABCD Consortium. Rates of incidental findings in brain magnetic resonance imaging in children. JAMA Neurol 2021; 78 (05) 578-587
- 73 Kerr WT, Lee JK, Karimi AH. et al. A minority of patients with functional seizures have abnormalities on neuroimaging. J Neurol Sci 2021; 427 (June): 117548
- 74 Schwingenschuh P, Saifee TA, Katschnig-Winter P. et al. Validation of “laboratory-supported” criteria for functional (psychogenic) tremor. Mov Disord 2016; 31 (04) 555-562
- 75 Saranza G, Vargas-Mendez D, Lang AE, Chen R. Suggestibility as a valuable criterion for laboratory-supported definite functional movement disorders. Clin Neurophysiol Pract 2021; 6: 103-108
- 76 Chen KS, Chen R. Principles of electrophysiological assessments for movement disorders. J Mov Disord 2020; 13 (01) 27-38
- 77 Gaig C, Martí MJ, Tolosa E. et al. 123I-Ioflupane SPECT in the diagnosis of suspected psychogenic Parkinsonism. Mov Disord 2006; 21 (11) 1994-1998
- 78 Walzl D, Carson AJ, Stone J. The misdiagnosis of functional disorders as other neurological conditions. J Neurol 2019; 266 (08) 2018-2026
- 79 Gelauff JM, Carson A, Ludwig L, Tijssen MAJ, Stone J. The prognosis of functional limb weakness: a 14-year case-control study. Brain 2019; 142 (07) 2137-2148
- 80 Stone J, Smyth R, Carson A. et al. Systematic review of misdiagnosis of conversion symptoms and “hysteria”. BMJ 2005; 331 (7523): 989-991
- 81 Coebergh JA, Wren DR, Mumford CJ. ‘Undiagnosing’ neurological disease: how to do it, and when not to. Pract Neurol 2014; 14 (06) 436-439
- 82 Shill H, Gerber P. Evaluation of clinical diagnostic criteria for psychogenic movement disorders. Mov Disord 2006; 21 (08) 1163-1168
- 83 Thomas M, Vuong KD, Jankovic J. Long-term prognosis of patients with psychogenic movement disorders. Parkinsonism Relat Disord 2006; 12 (06) 382-387
- 84 Jankovic J, Vuong KD, Thomas M. Psychogenic tremor: long-term outcome. CNS Spectr 2006; 11 (07) 501-508
- 85 Ettinger AB, Dhoon A, Weisbrot DM, Devinsky O. Predictive factors for outcome of nonepileptic seizures after diagnosis. J Neuropsychiatry Clin Neurosci 1999; 11 (04) 458-463
- 86 Stone J. Functional neurological disorders: the neurological assessment as treatment. Pract Neurol 2016; 16 (01) 7-17
- 87 Stone J, Carson A, Hallett M. Explanation as treatment for functional neurologic disorders. Handb Clin Neurol 2016; 139: 543-553
- 88 Stone J, Edwards M. Trick or treat? Showing patients with functional (psychogenic) motor symptoms their physical signs. Neurology 2012; 79 (03) 282-284
- 89 MacDuffie KE, Grubbs L, Best T. et al. Stigma and functional neurological disorder: a research agenda targeting the clinical encounter. CNS Spectr 2020; 26 (06) 1-6
- 90 Gelauff JM, Rosmalen JGM, Carson A. et al. Internet-based self-help randomized trial for motor functional neurologic disorder (SHIFT). Neurology 2020; 95 (13) e1883-e1896
- 91 Lidstone SC, MacGillivray L, Lang AE. Integrated therapy for functional movement disorders: time for a change. Mov Disord Clin Pract (Hoboken) 2020; 7 (02) 169-174
- 92 Edwards MJ. Functional neurological disorder: lighting the way to a new paradigm for medicine. Brain 2021; 144 (11) 3279-3282
- 93 NHS Scotland. Stepped care for functional neurological symptoms. Healthc Improv Scotl 2012. Accessed February 6, 2023 at: https://www.healthcareimprovementscotland.org/idoc.ashx?docid=6d302668-ff12-4f53-b547-72c19531e37a&version=-1
- 94 Stone J, Sharpe M, Rothwell PM, Warlow CP. The 12 year prognosis of unilateral functional weakness and sensory disturbance. J Neurol Neurosurg Psychiatry 2003; 74 (05) 591-596
- 95 Duncan R, Horwood J, Razvi S, Mulhern S. Psychogenic nonepileptic seizures that remit when the diagnosis is given: Just good luck?. Epilepsy Behav 2020; 102: 106667
- 96 MacGillivray L, Lidstone SC. The biopsychosocial formulation for functional movement disorder. In: LaFaver K, Maurer CW, Nicholson TR, Perez DL. eds. Functional Movement Disorder: An Interdisciplinary Case-Based Approach. Totowa, NJ: Humana Press; 2022