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CC BY 4.0 · Indian J Med Paediatr Oncol 2023; 44(03): 365-370
DOI: 10.1055/s-0043-1761263
Case Report with Review of Literature

Radiation Recall Dermatitis in Breast Cancer Patient after Trastuzumab: A Case Report with Review of Literature

Rohit Avinash Vadgaonkar 
1   Department of Radiation Oncology, Breast Cancer Management Group, Homi Bhabha Cancer Hospital and Research Centre, Visakhapatnam, Andhra Pradesh, India
,
Pradeep Ventrapati
2   Department of Medical Oncology, Breast Cancer Management Group, Homi Bhabha Cancer Hospital and Research Centre, Visakhapatnam, Andhra Pradesh, India
,
Ankita Mehta
1   Department of Radiation Oncology, Breast Cancer Management Group, Homi Bhabha Cancer Hospital and Research Centre, Visakhapatnam, Andhra Pradesh, India
,
Anupurva Dutta
3   Department of Pathology, Breast Cancer Management Group, Homi Bhabha Cancer Hospital and Research Centre, Visakhapatnam, Andhra Pradesh, India
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Abstract

Radiation recall dermatitis (RRD) is an extremely rare phenomenon. A variety of factors such as antineoplastic agents, pharmaceutical agents, physical and environmental factors have been proposed to be the underlying cause of RRD. Only a handful cases have been reported till date, where trastuzumab is sought to be the triggering agent. The presentation of RRD varies from mild erythematous to extensive confluent dermatitis, resolving over a period of 1 to 2 weeks with conservative management. Most of the patients tend to tolerate rechallenge well without showing reappearance. We hereby describe a lady with breast cancer having RRD following administration of trastuzumab. She developed reaction 28 days post-radiotherapy and managed conservatively. Furthermore, she was rechallenged with the same dose, that she tolerated very well, without any reappearance. Hence, an acquaintance of the clinicians to this rare entity is essential for timely diagnosis and appropriate management.

Keywords

radiation recall dermatitis - trastuzumab - radiation recall phenomenon


Publication History

Article published online:
12 May 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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