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Diabetologie und Stoffwechsel 2018; 13(01): 35-45
DOI: 10.1055/s-0043-123603
DuS-Refresher
© Georg Thieme Verlag KG Stuttgart · New York

Nahrungsergänzungsmittel bei Diabetes

Dietary supplements in diabetes
Theresa van Gemert
,
Katharina Weber
,
Karsten Müssig
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Publikationsverlauf

Publikationsdatum:
27. Februar 2018 (online)

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Abstract

Dietary supplements are defined as foods intended to complete the general diet especially in special metabolic situations like pregnancy or vitamin deficiencies. Furthermore, dietary supplements seem to get increasingly important with regard to prevention and management of diabetes. So far the German, European and Canadian Diabetes Associations as well as the Diabetes Associations of the US and UK do not give specific recommendation for dietary supplements to reduce the risk of diabetes or improve the glycemic control in patients with diabetes. By assessing new findings, the present article gives a literature overview based on comprehensive meta-analyses of selected dietary supplements, which are frequently discussed in combination with diabetes. Currently, there is a consensus that a balanced diet ensures a sufficient supply of micronutrients. Current studies on the use of magnesium, chrome, selenium, vitamin D, vitamin E and omega-3 fatty acids in people with increased risk of diabetes or manifest diabetes showed inconsistent results. Therefore, further randomized controlled trials with sufficient number of participants are necessary in order to provide concrete evidence-based recommendations.

Die Einnahme von Nahrungsergänzungsmitteln (NEM) wird immer beliebter – insbesondere im Zusammenhang mit der Prävention und Behandlung verschiedener Erkrankungen werden NEM immer häufiger diskutiert. Doch ist die Einnahme von NEM für Menschen mit Diabetes bzw. zur Prävention des Diabetes sinnvoll? Dieser Beitrag beleuchtet einige NEM, zu denen aktuelle Metaanalysen vorliegen, u. a. hinsichtlich Diabetesrisiko und glykämischer Kontrolle.

Schlüsselwörter

Diabetesprävention - Magnesium - Chrom - Selen - Vitamin D - Vitamin E - N-3-Fettsäuren

Key words

diabetes prevention - magnesium - chrome - selenium - vitamin D - vitamin E - n-3 fatty acids
 

  • Literatur

  • 1 Das Europäische Parlament und der Rat der Europäischen Union. Richtlinie 2002/46/EG. Im Internet: 2002 http://eur-lex.europa.eu/legal-content/DE/TXT/?uri=CELEX%3A32002L0046 Stand: 04.01.2018
    PubMedGoogle Scholar
  • 2 Bundesamt für Verbraucherschutz und Lebensmittelsicherheit. Viele Wege – ein Ziel: Sichere Lebensmittel. Im Internet: http://www.bvl.bund.de/DE/01_Lebensmittel/lm_node.html Stand: 04.01.2018
    Google Scholar
  • 3 Max Rubner-Institut und Bundesforschungsinstitut für Ernährung und Lebensmittel. Ergebnisbericht, Teil 1 Nationale Verzehrsstudie II. Im Internet: 2008 http://www.bmel.de/DE/Ernaehrung/GesundeErnaehrung/_Texte/NationaleVerzehrsstudie_Zusammenfassung.html Stand: 04.01.2018
    PubMedGoogle Scholar
  • 4 Verbraucherzentralen. Repräsentative forsa-Umfrage im Auftrag von Klartext Nahrungsergaenzung.de. September 2016. Im Internet: http://www.vzbv.de/pressemitteilung/verbraucherzentralen-fuer-klartext-bei-nahrungsergaenzungsmitteln Stand: 04.01.2018
    Google Scholar
  • 5 Mann JI, De Leeuw I, Hermansen K. et al. Evidence-based nutritional approaches to the treatment and prevention of diabetes mellitus. Nutr Metab Cardiovasc Dis 2004; 14: 373-394
    CrossrefPubMedGoogle Scholar
  • 6 Toeller M. Ernährungsempfehlungen bei Diabetes und deren Implementierung. Diabetologe 2009; 5: 442-452
    CrossrefGoogle Scholar
  • 7 American Diabetes Association. Foundations of care: education, nutrition, physical activity, smoking cessation, psychosocial care, and immunization. Diabetes Care 2015; (Suppl. 38) 20-30
    Google Scholar
  • 8 Dworatzek PD, Arcudi K, Gougeon R. et al. Nutrition therapy. Can J Diabetes 2013; 37: 45-55
    CrossrefPubMedGoogle Scholar
  • 9 Gröber U, Schmidt J, Kisters K. Magnesium in prevention and therapy. Nutrients 2015; 7: 8199-8226
    CrossrefPubMedGoogle Scholar
  • 10 Fang X, Han H, Li M. et al. Dose-response relationship between dietary magnesium intake and risk of type 2 diabetes mellitus: a systematic review and meta-regression analysis of prospective cohort studies. Nutrients 2016; 8: 1-18
    Google Scholar
  • 11 Suksomboon N, Poolsup N, Yuwanakorn A. Systematic review and meta-analysis of the efficacy and safety of chromium supplementation in diabetes. J Clin Pharm Ther 2014; 39: 292-306
    CrossrefPubMedGoogle Scholar
  • 12 Yin RV, Phung OJ. Effect of chromium supplementation on glycated hemoglobin and fasting plasma glucose in patients with diabetes mellitus. Nutr J 2015; 14: 1-9
    CrossrefPubMedGoogle Scholar
  • 13 Rayman MP, Stranges S. Epidemiology of selenium and type 2 diabetes: can we make sense of it?. Free Radic Biol Med 2013; 65: 1557-1564
    CrossrefPubMedGoogle Scholar
  • 14 Stranges S, Marshall JR, Natarajan R. et al. Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial. Ann Intern Med 2007; 147: 217-223
    CrossrefPubMedGoogle Scholar
  • 15 Poolsup N, Suksomboon N, Plordplong N. Effect of vitamin D supplementation on insulin resistance and glycaemic control in prediabetes: a systematic review and meta-analysis. Diabet Med J Br Diabet Assoc 2016; 33: 290-299
    CrossrefPubMedGoogle Scholar
  • 16 Seida JC, Mitri J, Colmers IN. et al. Clinical review: Effect of vitamin D3 supplementation on improving glucose homeostasis and preventing diabetes: a systematic review and meta-analysis. J Clin Endocrinol Metab 2014; 99: 3551-3560
    CrossrefPubMedGoogle Scholar
  • 17 Suksomboon N, Poolsup N, Sinprasert S. Effects of vitamin E supplementation on glycaemic control in type 2 diabetes: systematic review of randomized controlled trials. J Clin Pharm Ther 2011; 36: 53-63
    CrossrefPubMedGoogle Scholar
  • 18 Ceriello A, Giugliano D, Quatraro A. et al. Vitamin E reduction of protein glycosylation in diabetes. New prospect for prevention of diabetic complications?. Diabetes Care 1991; 14: 68-72
    CrossrefPubMedGoogle Scholar
  • 19 Rahimi-Madiseh M, Malekpour-Tehrani A, Bahmani M. et al. The research and development on the antioxidants in prevention of diabetic complications. Asian Pac J Trop Med 2016; 9: 825-831
    CrossrefPubMedGoogle Scholar
  • 20 Pazdro R, Burgess JR. The role of vitamin E and oxidative stress in diabetes complications. Mech Ageing Dev 2010; 131: 276-286
    CrossrefPubMedGoogle Scholar
  • 21 Patel PS, Sharp SJ, Luben RN. et al. Association between type of dietary fish and seafood intake and the risk of incident type 2 diabetes: the European prospective investigation of cancer (EPIC)-Norfolk cohort study. Diabetes Care 2009; 32: 1857-1863
    CrossrefPubMedGoogle Scholar
  • 22 Djoussé L, Gaziano JM, Buring JE. et al. Dietary omega-3 fatty acids and fish consumption and risk of type 2 diabetes. Am J Clin Nutr 2011; 93: 143-150
    CrossrefPubMedGoogle Scholar
  • 23 Zheng JS, Huang T, Yang J. et al. Marine N-3 polyunsaturated fatty acids are inversely associated with risk of type 2 diabetes in Asians: a systematic review and meta-analysis. PloS One 2012; 7: 1-14
    Google Scholar
  • 24 Wallin A, Di Giuseppe D, Orsini N. et al. Fish consumption, dietary long-chain n-3 fatty acids, and risk of type 2 diabetes: systematic review and meta-analysis of prospective studies. Diabetes Care 2012; 35: 918-929
    CrossrefPubMedGoogle Scholar
  • 25 Hartweg J, Perera R, Montori V. et al. Omega-3 polyunsaturated fatty acids (PUFA) for type 2 diabetes mellitus. Cochrane Database Syst Rev 2008; 7: 1-63
    Google Scholar
  • 26 Farmer A, Montori V, Dinneen S. et al. Fish oil in people with type 2 diabetes mellitus. Cochrane Database Syst Rev 2001; 1: 1-33
    Google Scholar
  • 27 van Gemert T, Weber KS, Müssig K. Update – Nahrungsergänzungsmittel bei Diabetes. diabetologie-online Congress-Report 2017; 3: 28-31
    Google Scholar