PDF herunterladen
Ernährung & Medizin 2017; 32(03): 113-116
DOI: 10.1055/s-0043-114481
wissen
Haug Verlag in Georg Thieme Verlag KG Stuttgart

Folat und Folsäure

Teil 2: Folat und seine Rolle unter bestimmten medizinischen Bedingungen
Szabolcs Péter
1   MD, PhD, DSM Nutritional Products Ltd. R&D Human Nutrition and Health
,
Manfred Eggersdorfer
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
30. August 2017 (online)

Auch verfügbar auf
    Lizenzen und Reprints

Teil 1 des Beitrags über Folat und Folsäure widmete sich den ernährungswissenschaftlichen Aspekten des Vitamins bzw. der synthetischen Vorstufe sowie seiner zentralen Funktion im Zellstoffwechsel und bei der Synthese der Amino- und Nukleinsäuren. Nun sollen mit Blick auf die aktuelle Studienlage einzelne medizinische Auswirkungen eines Folatmangels und deren Vorbeugung bzw. Therapie mit Folsäure-Supplementation betrachtet werden.

 

  • Literatur

  • 1 Stabler SP. Clinical folate deficiency. In: Bailey LB. ed. Folate in Health and Disease. Boca Raton, FL: CRC press Taylor & Francis Group; 2010: 409-428
    Google Scholar
  • 2 Halsted CH, Villanueva JA, Devlin AM, Chandler CJ. Metabolic interactions of alco-hol and folate. J Nutr 2002; 132 (8 Suppl.): 2367S-2372S
    CrossrefPubMedGoogle Scholar
  • 3 Pfeiffer CM, Sternberg MR, Schleicher RL, Rybak ME. Dietary supplement use and smoking are important correlates of biomarkers of water-soluble vitamin status after adjusting for sociodemographic and lifestyle variables in a representative sample of U.S. adults. J Nutr 2013; 143: 957S-965S
    CrossrefPubMedGoogle Scholar
  • 4 Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press; 1998
    CrossrefGoogle Scholar
  • 5 Honein MA, Paulozzi LJ, Methews TJ. et al. Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA 2001; 285: 2981-2986
    CrossrefPubMedGoogle Scholar
  • 6 Laurence KM, James N, Miller MH. et al. Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects. Br Med J (Clin Res Ed) 1981; 282: 1509-1511
    CrossrefPubMedGoogle Scholar
  • 7 Eskes TK. Open or closed? A world of difference: a history of homocysteine research. Nutr Rev 1998; 56: 236-244
    PubMedGoogle Scholar
  • 8 van Beynum IM, Kapusta L, Bakker MK. et al. Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects: a registry-based case-control study in the northern Netherlands. Eur Heart J 2010; 31: 464-471
    CrossrefPubMedGoogle Scholar
  • 9 Badovinac RL, Werler MM, Williams PL. et al. Folic acid-containing supplement consumption during pregnancy and risk for oral clefts: a meta-analysis. Birth Defects Res A Clin Mol Teratol 2007; 79: 8-15
    CrossrefPubMedGoogle Scholar
  • 10 MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991; 338: 131-137
    CrossrefPubMedGoogle Scholar
  • 11 Baker PN, Wheeler SJ, Sanders TA. et al. A prospective study of micronutrient status in adolescent pregnancy. Am J Clin Nutr 2009; 89: 1114-1124
    CrossrefPubMedGoogle Scholar
  • 12 Scholl TO, Johnson WG. Folic acid: influence on the outcome of pregnancy. Am J Clin Nutr 2000; 71 (5 Suppl.): 1295S-1303S
    CrossrefPubMedGoogle Scholar
  • 13 Brown SB, Reeves KW, Bertone-Johnson ER. Maternal folate exposure in pregnancy and childhood asthma and allergy: a systematic review. Nutr Rev 2014; 72: 55-64
    CrossrefPubMedGoogle Scholar
  • 14 Gerhard GT, Duell PB. Homocysteine and atherosclerosis. Curr Opin Lipidol 1999; 10: 417-428
    CrossrefPubMedGoogle Scholar
  • 15 Malinow MR, Bostom AG, Krauss RM. Homocyst(e)ine, diet, and cardiovascular diseases: a statement for healthcare professionals from the Nutrition Committee, American Heart Association. Circulation 1999; 99: 178-182
    CrossrefPubMedGoogle Scholar
  • 16 Voutilainen S, Rissanen TH, Virtanen J. et al. Low dietary folate intake is associated with an excess incidence of acute coronary events: The Kuopio Ischemic Heart Disease Risk Factor Study. Circulation 2001; 103: 2674-2680
    CrossrefPubMedGoogle Scholar
  • 17 Homocysteine Lowering Trialists’ Collaboration. Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr 2005; 82: 806-812
    CrossrefPubMedGoogle Scholar
  • 18 Kim YI. Does a high folate intake increase the risk of breast cancer?. Nutr Rev 2006; 64: 468-475
    CrossrefPubMedGoogle Scholar
  • 19 Sellers TA, Kushi LH, Cerhan JR. et al. Dietary folate intake, alcohol, and risk of breast cancer in a prospective study of postmenopausal women. Epidemiology 2001; 12: 420-428
    CrossrefPubMedGoogle Scholar
  • 20 Zhang S, Hunter DJ, Hankinson SE. et al. A prospective study of folate intake and the risk of breast cancer. JAMA 1999; 281: 1632-1637
    CrossrefPubMedGoogle Scholar
  • 21 Su LJ, Arab L. Nutritional status of folate and colon cancer risk: evidence from NHANES I epidemiologic follow-up study. Ann Epide-miol 2001; 11: 65-72
    CrossrefPubMedGoogle Scholar
  • 22 Giovannucci E, Rimm EB, Ascherio A. et al. Alcohol, low-methionine–low-folate diets, and risk of colon cancer in men. J Natl Cancer Inst 1995; 87: 265-273
    CrossrefPubMedGoogle Scholar
  • 23 Cole BF, Baron JA, Sandler RS. et al. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 2007; 297: 2351-2359
    CrossrefPubMedGoogle Scholar
  • 24 Figueiredo JC, Grau MV, Haile RW. et al. Folic acid and risk of prostate cancer: results from a randomized clinical trial. J Natl Cancer Inst 2009; 101: 432-435
    CrossrefPubMedGoogle Scholar
  • 25 Figueiredo JC, Mott LA, Giovannucci E. et al. Folic acid and prevention of colorectal adenomas: a combined analysis of randomized clinical trials. Int J Cancer 2011; 129: 192-203
    CrossrefPubMedGoogle Scholar
  • 26 Vollset SE, Clarke R, Lewington S. et al. Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50 000 individuals. Lancet 2013; 381: 1029-1036
    CrossrefPubMedGoogle Scholar
  • 27 Shen L, Ji HF. Associations between homocysteine, folic acid, vitamin B, and Alzheimer’s disease: insights from meta-analyses. J Alzheimers Dis 2015; 46: 777-790
    CrossrefPubMedGoogle Scholar
  • 28 Luchsinger JA, Tang MX, Miller J. Relation of higher folate intake to lower risk of Alzheimer disease in the elderly. Arch Neurol 2007; 64: 86-92
    CrossrefPubMedGoogle Scholar
  • 29 Morris MC, Evans DA, Schneider JA. et al. Dietary folate and vitamins B-12 and B-6 not associated with incident Alzheimer‘s disease. J Alzheimers Dis 2006; 9: 435-443
    CrossrefPubMedGoogle Scholar
  • 30 Morris MC, Evans DA, Bienias JL. et al. Dietary folate and vitamin B intake and cognitive decline among community-dwelling older persons. Arch Neurol 2005; 62: 641-645
    CrossrefPubMedGoogle Scholar
  • 31 Alpert JE, Mischoulon D, Nierenberg AA, Fava M. Nutrition and depression: focus on folate. Nutrition 2000; 16: 544-546
    CrossrefPubMedGoogle Scholar
  • 32 Wiesinger H, Eydeler U, Richard F. et al. Bioequivalence evaluation of a folate-supplemented oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium versus ethinylestradiol/drospirenone and levomefolate calcium alone. Clin Drug Investig 2012; 32: 673-684
    CrossrefPubMedGoogle Scholar
  • 33 Tinker SC, Cogswell ME, Devine O. et al. Folic acid intake among U.S. women aged 15–44 years, National Health and Nutrition Examination Survey, 2003-2006. Am J Prev Med 2010; 38: 534-542
    CrossrefPubMedGoogle Scholar