Möglichkeiten und Grenzen der ketogenen Ernährung in der Krebstherapie

Summary

Eine ketogene Ernährung mit einem sehr hohen Fettanteil und einer Verknappung von Glukose zeigt tierexperimentell günstige Effekte auf Tumorwachstum und Überleben. In der humanen Krebstherapie deuten sich positive Wirkungen der ketogenen Diät in der Kombination mit Strahlen- und Chemotherapie an.

Keywords

Ketogene Diäten - Krebstherapie - Blutzuckerspiegel - β-Hydroxybutyrat - Tumorwachstum - Supportivtherapie

• Literatur

• 1 Barber MD, McMillan DC, Preston T. et al. Metabolic response to feeding in weight-losing pancreatic cancer patients and its modulation by a fish-oil-enriched nutritional supplement. Clin Sci 2000; 98 (04) 389-399
• 2 Shukla SK, Gebregiworgis T, Purohit V. et al. Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia. Cancer Metab 2014; 2: 18
• 3 Klement RJ, Champ CE, Otto C, Kämmerer U. Anti-Tumor Effects of Ketogenic Diets in Mice: A Meta-Analysis. PLoS One 2016; 11: e0155050
• 4 Rojas-Morales P, Tapia E, Pedraza-Chaverri J. β-Hydroxybutyrate: A signaling metabolite in starvation response?. Cell Signal 2016; 28: 917-923
• 5 Chandrasekera PC, Pippin JJ. Of Rodents and Men: Species-Specific Glucose Regulation and Type 2 Diabetes Research. ALTEX 2013; 31: 157-176
• 6 Mahoney LB, Denny CA, Seyfried TN. Calorie restriction in C57BL/6J mice mimics therapeutic fasting in humans. Lipids Health Dis 2006; 5: 13
• 7 Schmidt M, Pfetzer N, Schwab M. et al. Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial. Nutr Metab 2011; 8: 54
• 8 Rieger J, Bähr O, Maurer GD. et al. ERGO: A pilot study of ketogenic diet in recurrent glioblastoma. Int J Oncol 2014; 44: 1843-1852
• 9 Schwartz K, Chang HT, Nikolai M. et al. Treatment of glioma patients with ketogenic diets: report of two cases treated with an IRB-approved energy-restricted ketogenic diet protocol and review of the literature. Cancer Metab 2015; 3: 3
• 10 Bozzetti F, Gavazzi C, Mariani L, Crippa F. Glucose-based total parenteral nutrition does not stimulate glucose uptake by human tumours. Clin Nutr 2004; 23: 417-421
• 11 Fine EJ, Segal-isaacson CJ, Feinman RD. et al. Targeting insulin inhibition as a metabolic therapy in advanced cancer: A pilot safety and feasibility dietary trial in 10 patients. Nutrition 2012; 28: 1028-1035
• 12 Schroeder U, Himpe B, Pries R. et al. Decline of lactate in tumor tissue after ketogenic diet: in vivo microdialysis study in patients with head and neck cancer. Nutr Cancer 2013; 65: 843-849
• 13 Klement RJ, Champ CE. Calories, carbohydrates, and cancer therapy with radiation: Exploiting the five R’s through dietary manipulation. Cancer Metastasis Rev 2014; 33: 217-229
• 14 Klement RJ, Sweeney R. Impact of a ketogenic diet intervention during radiotherapy on body composition: I. Initial clinical experience with six prospectively studied patients. BMC Res Notes 2016; 9: 143
• 15 Brandhorst S, Harputlugil E, Mitchell JR, Longo VD. Protective effects of short-term dietary restriction in surgical stress and chemotherapy. Ageing Res Rev 2017 Feb 20. pii: S1568–1637(17)30033–8. [Epub ahead of print]
• 16 de Groot S, Vreeswijk MP, Welters MJ. et al. The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study. BMC Cancer 2015; 15: 652
• 17 Dorff TB, Groshen S, Garcia A. et al. Safety and feasibility of fasting in combination with platinum-based chemotherapy. BMC Cancer 2016; 16: 360
• 18 Klement RJ. Fasten als Nebenwirkungsmanagement?. InFo Onkol 2016; 19: 22-24
• 19 Kearns CE, Schmidt LA, Glantz SA. Sugar Industry and Coronary Heart Disease Research: A Historical Analysis of Internal Industry Documents. JAMA Intern Med 2016; 176 (11) 1680-1685