CC BY-NC-ND 4.0 · Endosc Int Open 2017; 05(08): E736-E741
DOI: 10.1055/s-0043-112493
Original article
Eigentümer und Copyright ©Georg Thieme Verlag KG 2017

Efficacy and safety of endoscopic submucosal dissection for superficial cancer of the cervical esophagus

Toshiro Iizuka
1   Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan
2   Department of Upper Gastrointestinal Surgery, Juntendo University, Tokyo, Japan
,
Daisuke Kikuchi
1   Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan
,
Shu Hoteya
1   Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan
,
Yoshiaki Kajiyama
2   Department of Upper Gastrointestinal Surgery, Juntendo University, Tokyo, Japan
,
Mitsuru Kaise
1   Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan
› Author Affiliations
Further Information

Publication History

submitted 04 April 2017

accepted after revision 02 May 2017

Publication Date:
07 August 2017 (online)

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Abstract

Background and study aims Cervical esophageal cancer (CEC) is a less common form of cancer and often locally advanced at the time of diagnosis; thus, survival rates for patients with CEC remain poor. However, no reports exist on results of endoscopic submucosal dissection (ESD) for superficial cancer at the cervical esophagus. The aim of this retrospective study was to elucidate the clinicopathological features and clinical outcomes of ESD for superficial CEC.

Patients and methods ESD was performed on 891 lesions (in 662 patients) for superficial esophageal cancer from January 2008 to December 2015. Of these, 45 lesions (45 patients) were enrolled in the case group (CEC), and 405 lesions (375 patients) were enrolled in the control group (superficial cancer in the middle thoracic esophagus). The safety of ESD, including R0 resection rate and adverse events, and the efficacy, such as the local recurrence rate and overall survival rate, were evaluated.

Results The R0 resection rate was 91.1 % in the case group and 96 % in the control group. The rate of esophageal stricture was significantly higher in the case group (20 %) than in the control group (6.6 %). There was no local recurrence, and the 3-year survival rate was 88.4 % in the case group and 96.7 % in the control group.

Conclusions ESD for superficial cancer in the cervical esophagus was achieved safely, and successful local control was also confirmed. However, the esophageal stricture after ESD was more frequent.