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DOI: 10.1055/s-0043-111801
Behandlung des retinalen Venenverschlusses – Welche Rolle spielt die Vitrektomie heute noch?
Treatment of Retinal Vein Occlusion – Is There Still a Role for Vitreoretinal Surgery?Publication History
eingereicht 10 April 2017
akzeptiert 25 April 2017
Publication Date:
06 July 2017 (online)
Zusammenfassung
Chirurgische Verfahren zur Behandlung des retinalen Venenverschlusses hatten ihre Hochzeit Ende des letzten und Anfang dieses Jahrhunderts. Die zu Beginn berichteten und überschwänglich beurteilten Ergebnisse konnten in prospektiven und randomisierten Studien nicht bestätigt werden. Auch reichte der damals beschriebene funktionelle Effekt nicht an den Effekt der heutzutage üblichen Injektionstherapie heran, weshalb die Verfahren mittlerweile zu Recht keine Rolle mehr im klinischen Alltag spielen. Die Verfahren, die theoretischen Überlegungen und die Kritikpunkte an der Vitrektomie, der radiären Optikoneurotomie (RON), der retinalen endovasalen Fibrinolyse (REVL) und der arteriovenösen Dissektion (AVD) sollen in diesem Beitrag besprochen werden.
Abstract
Surgical manoeuvres for the treatment of retinal vein occlusion peaked at the turn of the century. The first overwhelming reports could not be confirmed in prospective studies. Furthermore, the functional success was never comparable to intravitreal drug therapy, and the manoeuvres are no longer used in clinical routine. The procedures, the surgical theory and the criticism on vitrectomy, radial optic neurotomy (RON), retinal endovascular fibrinolysis (REVL) and arteriovenous dissection (AVD) will be discussed in this paper. Surgical manoeuvres for the treatment of retinal vein occlusion had a peak by the end of the last and the beginning of the present century. The first overwhelming reports could not be confirmed in prospective studies. Furthermore, the functional success was never comparable to the intravitreal drug therapy and the manoeuvres are no longer used in clinical routine. The procedures, the surgical theory and the criticism on vitrectomy, radial optic neurotomy (RON), retinal endovascular fibrinolysis (REVL), and arteriovenous dissection (AVD) will be discussed in this paper.
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Literatur
- 1 Williamson TH, Grewal J, Gupta B. et al. Measurement of PO2 during vitrectomy for central retinal vein occlusion, a pilot study. Graefes Arch Clin Exp Ophthalmol 2009; 247: 1019-1023
- 2 Stefánsson E. Physiology of vitreous surgery. Graefes Arch Clin Exp Ophthalmol 2009; 247: 147-163
- 3 Stefánsson E, Novack RL, Hatchell DL. Vitrectomy prevents retinal hypoxia in branch retinal vein occlusion. Invest Ophthalmol Vis Sci 1990; 31: 284-289
- 4 Stefánsson E, Landers MB, Wolbarsht ML. Vitrectomy, lensectomy, and ocular oxygenation. Retina 1982; 2: 159-166
- 5 Stefánsson E. The therapeutic effects of retinal laser treatment and vitrectomy. A theory based on oxygen and vascular physiology. Acta Ophthalmol Scand 2001; 79: 435-440
- 6 Okunuki Y, Usui Y, Katai N. et al. Relation of intraocular concentrations of inflammatory factors and improvement of macular edema after vitrectomy in branch retinal vein occlusion. Am J Ophthalmol 2011; 151: 610-616.e1
- 7 Tachi N, Hashimoto Y, Ogino N. Vitrectomy for macular edema combined with retinal vein occlusion. Doc Ophthalmol 1999; 97: 465-469
- 8 Saika S, Tanaka T, Miyamoto T. et al. Surgical posterior vitreous detachment combined with gas/air tamponade for treating macular edema associated with branch retinal vein occlusion: retinal tomography and visual outcome. Graefes Arch Clin Exp Ophthalmol 2001; 239: 729-732
- 9 Yamamoto S, Saito W, Yagi F. et al. Vitrectomy with or without arteriovenous adventitial sheathotomy for macular edema associated with branch retinal vein occlusion. Am J Ophthalmol 2004; 138: 907-914
- 10 Bertelmann T, Kicova N, Mennel S. et al. The impact of posterior vitreous adhesion on ischaemia in eyes with retinal vein occlusion. Acta Ophthalmol (Copenh) 2016; 94: e43-e48
- 11 Furino C, Ferrari TM, Boscia F. et al. Combined radial optic neurotomy, internal limiting membrane peeling, and intravitreal triamcinolone acetonide for central retinal vein occlusion. Ophthalmic Surg Lasers Imaging 2005; 36: 422-425
- 12 Mandelcorn MS, Nrusimhadevara RK. Internal limiting membrane peeling for decompression of macular edema in retinal vein occlusion: a report of 14 cases. Retina 2004; 24: 348-355
- 13 Liang XL, Chen HY, Huang YS. et al. Pars plana vitrectomy and internal limiting membrane peeling for macular oedema secondary to retinal vein occlusion: a pilot study. Ann Acad Med Singapore 2007; 36: 293-297
- 14 Adelman RA, Parnes AJ, Bopp S. et al. Strategy for the management of macular edema in retinal vein occlusion: The European Vitreoretinal Society Macular Edema Study. Biomed Res Int 2015; 2015: 870987
- 15 Radetzky S, Walter P, Fauser S. et al. Visual outcome of patients with macular edema after pars plana vitrectomy and indocyanine green-assisted peeling of the internal limiting membrane. Graefes Arch Clin Exp Ophthalmol 2004; 242: 273-278
- 16 Hvarfner C, Larsson J. Vitrectomy for non-ischaemic macular oedema in retinal vein occlusion. Acta Ophthalmol Scand 2006; 84: 812-814
- 17 Opremcak EM, Bruce RA, Lomeo MD. et al. Radial optic neurotomy for central retinal vein occlusion: a retrospective pilot study of 11 consecutive cases. Retina 2001; 21: 408-415
- 18 Opremcak EM, Rehmar AJ, Ridenour CD. et al. Radial optic neurotomy for central retinal vein occlusion: 117 consecutive cases. Retina 2006; 26: 297-305
- 19 Hayreh SS. Radial optic neurotomy for central retinal vein occlusion. Retina 2002; 22: 827
- 20 Vogel A, Holz FG, Loeffler KU. Histopathologic findings after radial optic neurotomy in central retinal vein occlusion. Am J Ophthalmol 2006; 141: 203-205
- 21 Friberg TR, Smolinski P, Hill S. et al. Biomechanical assessment of radial optic neurotomy. Ophthalmology 2008; 115: 174-180
- 22 Skevas C, Wagenfeld L, Feucht M. et al. Radial optic neurotomy in central retinal vein occlusion does not influence ocular hemodynamics. Int J Ophthalmol 2011; 225: 41-46
- 23 Crama N, Gualino V, Restori M. et al. Central retinal vessel blood flow after surgical treatment for central retinal vein occlusion. Retina 2010; 30: 1692-1697
- 24 Horio N, Horiguchi M. Retinal blood flow and macular edema after radial optic neurotomy for central retinal vein occlusion. Am J Ophthalmol 2006; 141: 31-34
- 25 Weizer JS, Stinnett SS, Fekrat S. Radial optic neurotomy as treatment for central retinal vein occlusion. Am J Ophthalmol 2003; 136: 814-819
- 26 Garcia-Arumi J, Boixadera A, Martinez-Castillo V. et al. Chorioretinal anastomosis after radial optic neurotomy for central retinal vein occlusion. Arch Ophthalmol 2003; 121: 1385-1391
- 27 Spaide RF, Klancnik JM, Gross NE. Retinal choroidal collateral circulation after radial optic neurotomy correlated with the lessening of macular edema. Retina 2004; 24: 356-359
- 28 Weinberg DV, Wahle AE, Ip MS. et al. Score Study Report 12: Development of venous collaterals in the Score Study. Retina 2013; 33: 287-295
- 29 Stoffelns BM, Kramann C, Hoffmann E. [Radial optic neurotomy (RON) for central retinal vein occlusion]. Klin Monatsbl Augenheilkd 2007; 224: 282-287
- 30 Aggermann T, Brunner S, Krebs I. et al. A prospective, randomised, multicenter trial for surgical treatment of central retinal vein occlusion: results of the Radial Optic Neurotomy for Central Vein Occlusion (ROVO) Study Group. Graefes Arch Clin Exp Ophthalmol 2013; 251: 1065-1072
- 31 Feltgen N, Herrmann J, Hansen L. [Visual field defect after radial optic neurotomy]. Ophthalmologe 2005; 102: 802-804
- 32 Roider J. [Radial opticus neurotomy]. Klin Monatsbl Augenheilkd 2005; 222: 132-133
- 33 Takaya K, Suzuki Y, Nakazawa M. Massive hemorrhagic retinal detachment during radial optic neurotomy. Graefes Arch Clin Exp Ophthalmol 2006; 244: 265-267
- 34 Weiss JN. Treatment of central retinal vein occlusion by injection of tissue plasminogen activator into a retinal vein. Am J Ophthalmol 1998; 126: 142-144
- 35 Weiss JN, Bynoe LA. Injection of tissue plasminogen activator into a branch retinal vein in eyes with central retinal vein occlusion. Ophthalmology 2001; 108: 2249-2257
- 36 Usui Y, Sauvage LR, Wu HD. et al. A comparative experimental study of the organization of arterial and venous thrombi. Ann Surg 1987; 205: 312-317
- 37 Hayreh SS. t-PA in CRVO. Ophthalmology 2002; 109: 1758-1761
- 38 Hattenbach LO, Friedrich Arndt C, Lerche R. et al. Retinal vein occlusion and low-dose fibrinolytic therapy (R.O.L.F.): a prospective, randomized, controlled multicenter study of low-dose recombinant tissue plasminogen activator versus hemodilution in retinal vein occlusion. Retina 2009; 29: 932-940
- 39 Feltgen N, Junker B, Agostini H. et al. Retinal endovascular lysis in ischemic central retinal vein occlusion: one-year results of a pilot study. Ophthalmology 2007; 114: 716-723
- 40 Feltgen N, Agostini H, Auw-Haedrich C. et al. Histopathological findings after retinal endovascular lysis in central retinal vein occlusion. BMJ Case Rep 2007; 91: 558-559
- 41 Yamamoto T, Kamei M, Sakaguchi H. et al. Comparison of surgical treatments for central retinal vein occlusion; RON vs. cannulation of tissue plasminogen activator into the retinal vein. Retina 2009; 29: 1167-1174
- 42 Pournaras CJ, Petropoulos IK, Pournaras JAC. et al. The rationale of retinal endovascular fibrinolysis in the treatment of retinal vein occlusion: from experimental data to clinical application. Retina 2012; 32: 1566-1573
- 43 Van Overdam KA, Missotten T, Spielberg LH. Updated cannulation technique for tissue plasminogen activator injection into peripapillary retinal vein for central retinal vein occlusion. Acta Ophthalmol (Copenh) 2015; 93: 739-744
- 44 Asami T, Kaneko H, Miyake K. et al. An endovascular cannulation needle with an internal wire for the fragmentation of thrombi in retinal vein occlusion. Transl Vis Sci Technol 2016; 5: 9
- 45 De Smet MD, Meenink TCM, Janssens T. et al. Robotic assisted cannulation of occluded retinal veins. PLoS One 2016; 11: e0162037
- 46 Willekens K, Gijbels A, Schoevaerdts L. et al. Robot-assisted retinal vein cannulation in an in vivo porcine retinal vein occlusion model. Acta Ophthalmol (Copenh) 2017; 95: 270-275
- 47 Osterloh M. Surgical decompression of branch retinal vein occlusions. Arch Ophthalmol 1988; 106: 1469-1471
- 48 Chung EJ, Freeman WR, Koh HJ. Visual acuity and multifocal electroretinographic changes after arteriovenous crossing sheathotomy for macular edema associated with branch retinal vein occlusion. Retina 2008; 28: 220-225
- 49 Noma H, Funatsu H, Sakata K. et al. Macular microcirculation before and after vitrectomy for macular edema with branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 2010; 248: 443-445
- 50 Kumagai K, Furukawa M, Ogino N. et al. Long-term outcomes of vitrectomy with or without arteriovenous sheathotomy in branch retinal vein occlusion. Retina 2007; 27: 49-54
- 51 Feltgen N, Auw-Haedrich C, Buchen R. et al. Arteriovenous dissection in a living human eye: clinicopathologic correlation. Arch Ophthalmol 2005; 123: 571-572
- 52 Turner EH, Matthews AM, Linardatos E. et al. Selective publication of antidepressant trials and its influence on apparent efficacy. N Engl J Med 2008; 358: 252-260
- 53 Fanelli D. Negative results are disappearing from most disciplines and countries. Scientometrics 2012; 90: 891-904
- 54 Feltgen N, Stahl A. [VEGF inhibitors in vitreoretinal interventions]. Klin Monatsbl Augenheilkd 2013; 110: 926-934