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Endoscopy 2017; 49(06): 588-608
DOI: 10.1055/s-0043-107029
Guideline
© Georg Thieme Verlag KG Stuttgart · New York

Role of endoscopy in primary sclerosing cholangitis: European Society of Gastrointestinal Endoscopy (ESGE) and European Association for the Study of the Liver (EASL) Clinical Guideline

Lars Aabakken
1   GI Endoscopy, Rikshospitalet University Hospital, Hospital, and Faculty of Medicine, University of Oslo,Oslo, Norway
,
Tom H. Karlsen
2   Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway
,
Jörg Albert
3   Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Robert-Bosch-Krankenhaus, Stuttgart, Germany
,
Marianna Arvanitakis
4   Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium
,
Olivier Chazouilleres
5   Service d’Hépatologie, Hôpital Saint-Antoine, Assistance Publique – Hôpitaux de Paris, Centre de référence des maladies inflammatoires du foie et des voies biliaires, Filière Maladies Rares du Foie de l’Adulte et de l’Enfant (FILFOIE), UPMC UNIV Paris 06, France
,
Jean-Marc Dumonceau
6   Gedyt Endoscopy Center, Buenos Aires, Argentina
,
Martti Färkkilä
7   Department of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
,
Peter Fickert
8   Research Unit for Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria
,
Gideon M. Hirschfield
9   National Institute for Health Research (NIHR), Birmingham Liver Biomedical Research Unit (BRU), and Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom
,
Andrea Laghi
10   Pathological Sciences, Sapienza-University, Rome, Italy
,
Marco Marzioni
11   Clinic of Gastroenterology and Hepatology, Università Politecnica delle Marche – Ospedali Riuniti University Hospital, Ancona, Italy
,
Michael Fernandez
4   Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium
,
Stephen P. Pereira
12   Institute for Liver and Digestive Health, University College London, Royal Free Campus, London, UK
,
Jürgen Pohl
13   Department of Gastroenterology and Interventional Endoscopy, Klinikum Friedrichshain, Berlin, Germany
,
Jan-Werner Poley
14   Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
,
Cyriel Y. Ponsioen
15   Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
,
Christoph Schramm
16   Department of Medicine I and Martin Zeitz Centre for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
,
Fredrik Swahn
17   Center for Digestive Diseases, Karolinska University Hospital and Division of Surgery, CLINTEC, Karolinska Institute, Stockholm, Sweden
,
Andrea Tringali
18   Digestive Endoscopy Unit, Catholic University, Rome, Italy
,
Cesare Hassan
19   Digestive Endoscopy Unit, Nuovo Regina Margherita Hospital, Rome, Italy
› Author Affiliations
Further Information

Publication History

Publication Date:
18 April 2017 (online)

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MAIN RECOMMENDATIONS

1 ESGE/EASL recommend that, as the primary diagnostic modality for PSC, magnetic resonance cholangiography (MRC) should be preferred over endoscopic retrograde cholangiopancreatography (ERCP).

Moderate quality evidence, strong recommendation.

2 ESGE/EASL suggest that ERCP can be considered if MRC plus liver biopsy is equivocal or contraindicated in patients with persisting clinical suspicion of PSC. The risks of ERCP have to be weighed against the potential benefit with regard to surveillance and treatment recommendations.

Low quality evidence, weak recommendation.

6 ESGE/EASL suggest that, in patients with an established diagnosis of PSC, MRC should be considered before therapeutic ERCP.

Weak recommendation, low quality evidence.

7 ESGE/EASL suggest performing endoscopic treatment with concomitant ductal sampling (brush cytology, endobiliary biopsies) of suspected significant strictures identified at MRC in PSC patients who present with symptoms likely to improve following endoscopic treatment.

Strong recommendation, low quality evidence.

9 ESGE/EASL recommend weighing the anticipated benefits of biliary papillotomy/sphincterotomy against its risks on a case-by-case basis.

Strong recommendation, moderate quality evidence.

Biliary papillotomy/sphincterotomy should be considered especially after difficult cannulation.

Strong recommendation, low quality evidence.

16 ESGE/EASL suggest routine administration of prophylactic antibiotics before ERCP in patients with PSC.

Strong recommendation, low quality evidence.

17 EASL/ESGE recommend that cholangiocarcinoma (CCA) should be suspected in any patient with worsening cholestasis, weight loss, raised serum CA19-9, and/or new or progressive dominant stricture, particularly with an associated enhancing mass lesion.

Strong recommendation, moderate quality evidence.

19 ESGE/EASL recommend ductal sampling (brush cytology, endobiliary biopsies) as part of the initial investigation for the diagnosis and staging of suspected CCA in patients with PSC.

Strong recommendation, high quality evidence.

Appendix e1

 

  • References

  • 1 Olsson R, Danielsson A, Jarnerot G. et al. Prevalence of primary sclerosing cholangitis in patients with ulcerative colitis. Gastroenterology 1991; 100: 1319-1323
    CrossrefPubMedGoogle Scholar
  • 2 Lunder AK, Hov JR, Borthne A. et al. Prevalence of sclerosing cholangitis, detected by magnetic resonance cholangiography, in patients with long-term inflammatory bowel disease. Gastroenterology 2016; 151: 660-669.e4
    CrossrefPubMedGoogle Scholar
  • 3 Boonstra K, van Erpecum KJ, van Nieuwkerk KM. et al. Primary sclerosing cholangitis is associated with a distinct phenotype of inflammatory bowel disease. Inflamm Bowel Dis 2012; 18: 2270-2276
    CrossrefPubMedGoogle Scholar
  • 4 O’Toole A, Alakkari A, Keegan D. et al. Primary sclerosing cholangitis and disease distribution in inflammatory bowel disease. Clin Gastroenterol Hepatol 2012; 10: 439-441
    CrossrefPubMedGoogle Scholar
  • 5 Loftus Jr. EV, Harewood GC, Loftus CG. et al. PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis. Gut 2005; 54: 91-96
    CrossrefPubMedGoogle Scholar
  • 6 EASL Clinical Practice Guidelines: management of cholestatic liver diseases. J Hepatol 2009; 51: 237-267
    CrossrefPubMedGoogle Scholar
  • 7 Atkins D, Eccles M, Flottorp S. et al. Systems for grading the quality of evidence and the strength of recommendations I: critical appraisal of existing approaches The GRADE Working Group. BMC Health Serv Res 2004; 4: 38
    CrossrefPubMedGoogle Scholar
  • 8 Chapman R, Fevery J, Kalloo A. et al. Diagnosis and management of primary sclerosing cholangitis. Hepatology 2010; 51: 660-678
    CrossrefPubMedGoogle Scholar
  • 9 Berstad AE, Aabakken L, Smith HJ. et al. Diagnostic accuracy of magnetic resonance and endoscopic retrograde cholangiography in primary sclerosing cholangitis. Clin Gastroenterol Hepatol 2006; 4: 514-520
    CrossrefPubMedGoogle Scholar
  • 10 Moff SL, Kamel IR, Eustace J. et al. Diagnosis of primary sclerosing cholangitis: a blinded comparative study using magnetic resonance cholangiography and endoscopic retrograde cholangiography. Gastrointest Endosc 2006; 64: 219-223
    CrossrefPubMedGoogle Scholar
  • 11 Philpott C, Rosenbaum J, Moon A. et al. Paediatric MRCP: 10 year experience with 195 patients. Eur J Radiol 2013; 82: 699-706
    CrossrefPubMedGoogle Scholar
  • 12 Rossi G, Sciveres M, Maruzzelli L. et al. Diagnosis of sclerosing cholangitis in children: blinded, comparative study of magnetic resonance versus endoscopic cholangiography. Clin Res Hepatol Gastroenterol 2013; 37: 596-601
    CrossrefPubMedGoogle Scholar
  • 13 Dave M, Elmunzer BJ, Dwamena BA. et al. Primary sclerosing cholangitis: meta-analysis of diagnostic performance of MR cholangiopancreatography. Radiology 2010; 256: 387-396
    CrossrefPubMedGoogle Scholar
  • 14 Meagher S, Yusoff I, Kennedy W. et al. The roles of magnetic resonance and endoscopic retrograde cholangiopancreatography (MRCP and ERCP) in the diagnosis of patients with suspected sclerosing cholangitis: a cost–effectiveness analysis. Endoscopy 2007; 39: 222-228
    Article in Thieme ConnectPubMedGoogle Scholar
  • 15 Talwalkar JA, Angulo P, Johnson CD. et al. Cost-minimization analysis of MRC versus ERCP for the diagnosis of primary sclerosing cholangitis. Hepatology 2004; 40: 39-45
    PubMedGoogle Scholar
  • 16 Kalaitzakis E, Levy M, Kamisawa T. et al. Endoscopic retrograde cholangiography does not reliably distinguish IgG4-associated cholangitis from primary sclerosing cholangitis or cholangiocarcinoma. Clin Gastroenterol Hepatol 2011; 9: 800-803 e2
    CrossrefPubMedGoogle Scholar
  • 17 Ruiz A, Lemoinne S, Carrat F. et al. Radiologic course of primary sclerosing cholangitis: assessment by three-dimensional magnetic resonance cholangiography and predictive features of progression. Hepatology 2014; 59: 242-250
    CrossrefPubMedGoogle Scholar
  • 18 Weber C, Kuhlencordt R, Grotelueschen R. et al. Magnetic resonance cholangiopancreatography in the diagnosis of primary sclerosing cholangitis. Endoscopy 2008; 40: 739-745
    Article in Thieme ConnectPubMedGoogle Scholar
  • 19 Eaton JE, Talwalkar JA, Lazaridis KN. et al. Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management. Gastroenterology 2013; 145: 521-536
    CrossrefPubMedGoogle Scholar
  • 20 Li-Yeng C, Goldberg HI. Sclerosing cholangitis: broad spectrum of radiographic features. Gastrointest Radiol 1984; 9: 39-47
    CrossrefPubMedGoogle Scholar
  • 21 Majoie CB, Reeders JW, Sanders JB. et al. Primary sclerosing cholangitis: a modified classification of cholangiographic findings. AJR Am J Roentgenol 1991; 157: 495-497
    CrossrefPubMedGoogle Scholar
  • 22 Ponsioen CY, Vrouenraets SM, Prawirodirdjo W. et al. Natural history of primary sclerosing cholangitis and prognostic value of cholangiography in a Dutch population. Gut 2002; 51: 562-566
    CrossrefPubMedGoogle Scholar
  • 23 Ponsioen CY, Reitsma JB, Boberg KM. et al. Validation of a cholangiographic prognostic model in primary sclerosing cholangitis. Endoscopy 2010; 42: 742-747
    Article in Thieme ConnectPubMedGoogle Scholar
  • 24 Craig DA, MacCarty RL, Wiesner RH. et al. Primary sclerosing cholangitis: value of cholangiography in determining the prognosis. AJR Am J Roentgenol 1991; 157: 959-964
    CrossrefPubMedGoogle Scholar
  • 25 Abdalian R, Heathcote EJ. Sclerosing cholangitis: a focus on secondary causes. Hepatology 2006; 44: 1063-1074
    CrossrefPubMedGoogle Scholar
  • 26 Trauner M, Fickert P, Wagner M. MDR3 (ABCB4) defects: a paradigm for the genetics of adult cholestatic syndromes. Semin Liver Dis 2007; 27: 77-98
    Article in Thieme ConnectPubMedGoogle Scholar
  • 27 Mesenas S, Vu C, Doig L. et al. Duodenal EUS to identify thickening of the extrahepatic biliary tree wall in primary sclerosing cholangitis. Gastrointest Endosc 2006; 63: 403-408
    CrossrefPubMedGoogle Scholar
  • 28 Rustemovic N, Cukovic-Cavka S, Opacic M. et al. Endoscopic ultrasound elastography as a method for screening the patients with suspected primary sclerosing cholangitis. Eur J Gastroenterol Hepatol 2010; 22: 748-753
    PubMedGoogle Scholar
  • 29 Lutz HH, Wasmuth HE, Streetz K. et al. Endoscopic ultrasound as an early diagnostic tool for primary sclerosing cholangitis: a prospective pilot study. Endoscopy 2012; 44: 934-939
    Article in Thieme ConnectPubMedGoogle Scholar
  • 30 EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. J Hepatol 2015; 63: 237-264
    CrossrefPubMedGoogle Scholar
  • 31 Cotton PB, Nickl N. Endoscopic and radiologic approaches to therapy in primary sclerosing cholangitis. Semin Liver Dis 1991; 11: 40-48
    Article in Thieme ConnectPubMedGoogle Scholar
  • 32 Johnson GK, Geenen JE, Venu RP. et al. Endoscopic treatment of biliary tract strictures in sclerosing cholangitis: a larger series and recommendations for treatment. Gastrointest Endosc 1991; 37: 38-43
    CrossrefPubMedGoogle Scholar
  • 33 Stiehl A, Rudolph G, Klöters-Plachky P. et al. Development of dominant bile duct stenoses in patients with primary sclerosing cholangitis treated with ursodeoxycholic acid: outcome after endoscopic treatment. J Hepatol 2002; 36: 151-156
    CrossrefPubMedGoogle Scholar
  • 34 Bjornsson E, Lindqvist-Ottosson J, Asztely M. et al. Dominant strictures in patients with primary sclerosing cholangitis. Am J Gastroenterol 2004; 99: 502-508
    CrossrefPubMedGoogle Scholar
  • 35 Gluck M, Cantone NR, Brandabur JJ. et al. A twenty-year experience with endoscopic therapy for symptomatic primary sclerosing cholangitis. J Clin Gastroenterol 2008; 42: 1032-1039
    CrossrefPubMedGoogle Scholar
  • 36 Ponsioen CY, Lam K, van Milligen de Wit AW. et al. Four years experience with short term stenting in primary sclerosing cholangitis. Am J Gastroenterol 1999; 94: 2403-2407
    CrossrefPubMedGoogle Scholar
  • 37 Boyd S, Tenca A, Jokelainen K. et al. Screening primary sclerosing cholangitis and biliary dysplasia with endoscopic retrograde cholangiography and brush cytology: risk factors for biliary neoplasia. Endoscopy 2016; 48: 432-439
    Article in Thieme ConnectPubMedGoogle Scholar
  • 38 Aljiffry M, Renfrew PD, Walsh MJ. et al. Analytical review of diagnosis and treatment strategies for dominant bile duct strictures in patients with primary sclerosing cholangitis. HPB (Oxford) 2011; 13: 79-90
    CrossrefPubMedGoogle Scholar
  • 39 Levy MJ, Baron TH, Clayton AC. et al. Prospective evaluation of advanced molecular markers and imaging techniques in patients with indeterminate bile duct strictures. Am J Gastroenterol 2008; 103: 1263-1273
    CrossrefPubMedGoogle Scholar
  • 40 Charatcharoenwitthaya P, Enders FB, Halling KC. et al. Utility of serum tumor markers, imaging, and biliary cytology for detecting cholangiocarcinoma in primary sclerosing cholangitis. Hepatology 2008; 48: 1106-1117
    CrossrefPubMedGoogle Scholar
  • 41 Chapman MH, Webster GJ, Bannoo S. et al. Cholangiocarcinoma and dominant strictures in patients with primary sclerosing cholangitis: a 25-year single-centre experience. Eur J Gastroenterol Hepatol 2012; 24: 1051-1058
    CrossrefPubMedGoogle Scholar
  • 42 Gotthardt DN, Rudolph G, Kloters-Plachky P. et al. Endoscopic dilation of dominant stenoses in primary sclerosing cholangitis: outcome after long-term treatment. Gastrointest Endosc 2010; 71: 527-534
    CrossrefPubMedGoogle Scholar
  • 43 Kaltenthaler E, Vergel YB, Chilcott J. et al. A systematic review and economic evaluation of magnetic resonance cholangiopancreatography compared with diagnostic endoscopic retrograde cholangiopancreatography. Health Technol Assess 2004; 8 iii: 1-89
    PubMedGoogle Scholar
  • 44 Baluyut AR, Sherman S, Lehman GA. et al. Impact of endoscopic therapy on the survival of patients with primary sclerosing cholangitis. Gastrointest Endosc 2001; 53: 308-312
    CrossrefPubMedGoogle Scholar
  • 45 van Milligen de Wit AW, van Bracht J, Rauws EA. et al. Endoscopic stent therapy for dominant extrahepatic bile duct strictures in primary sclerosing cholangitis. Gastrointest Endosc 1996; 44: 293-299
    CrossrefPubMedGoogle Scholar
  • 46 Kaya M, Petersen BT, Angulo P. et al. Balloon dilation compared to stenting of dominant strictures in primary sclerosing cholangitis. Am J Gastroenterol 2001; 96: 1059-1066
    CrossrefPubMedGoogle Scholar
  • 47 Cotton PB, Garrow DA, Gallagher J. et al. Risk factors for complications after ERCP: a multivariate analysis of 11,497 procedures over 12 years. Gastrointest Endosc 2009; 70: 80-88
    CrossrefPubMedGoogle Scholar
  • 48 Johnson GK, Saeian K, Geenen JE. Primary sclerosing cholangitis treated by endoscopic biliary dilation: review and long-term follow-up evaluation. Curr Gastroenterol Rep 2006; 8: 147-155
    CrossrefPubMedGoogle Scholar
  • 49 Lee JG, Schutz SM, England RE. et al. Endoscopic therapy of sclerosing cholangitis. Hepatology 1995; 21: 661-667
    PubMedGoogle Scholar
  • 50 Wagner S, Gebel M, Meier P. et al. Endoscopic management of biliary tract strictures in primary sclerosing cholangitis. Endoscopy 1996; 28: 546-551
    Article in Thieme ConnectPubMedGoogle Scholar
  • 51 Ahrendt SA, Pitt HA, Kalloo AN. et al. Primary sclerosing cholangitis: resect, dilate, or transplant?. Ann Surg 1998; 227: 412-423
    CrossrefPubMedGoogle Scholar
  • 52 Beuers U, Spengler U, Sackmann M. et al. Deterioration of cholestasis after endoscopic retrograde cholangiography in advanced primary sclerosing cholangitis. J Hepatol 1992; 15: 140-143
    CrossrefPubMedGoogle Scholar
  • 53 Dumonceau JM, Tringali A, Blero D. et al. Biliary stenting: indications, choice of stents and results: European Society of Gastrointest Endosc (ESGE) clinical guideline. Endoscopy 2012; 44: 277-292
    Article in Thieme ConnectPubMedGoogle Scholar
  • 54 Ismail S, Kylänpää L, Mustonen H. et al. Risk factors for complications of ERCP in primary sclerosing cholangitis. Endoscopy 2012; 44: 1133-1138
    Article in Thieme ConnectPubMedGoogle Scholar
  • 55 Navaneethan U, Jegadeesan R, Nayak S. et al. ERCP-related adverse events in patients with primary sclerosing cholangitis. Gastrointest Endosc 2015; 81: 410-419
    CrossrefPubMedGoogle Scholar
  • 56 van Milligen de Wit AW, Rauws EA, van Bracht J. et al. Lack of complications following short-term stent therapy for extrahepatic bile duct strictures in primary sclerosing cholangitis. Gastrointest Endosc 1997; 46: 344-347
    CrossrefPubMedGoogle Scholar
  • 57 van den Hazel SJ, Wolfhagen EH, van Buuren HR. et al. Prospective risk assessment of endoscopic retrograde cholangiography in patients with primary sclerosing cholangitis. Dutch PSC Study Group. Endoscopy 2000; 32: 779-782
    Article in Thieme ConnectPubMedGoogle Scholar
  • 58 Enns R, Eloubeidi MA, Mergener K. et al. Predictors of successful clinical and laboratory outcomes in patients with primary sclerosing cholangitis undergoing endoscopic retrograde cholangiopancreatography. Can J Gastroenterol 2003; 17: 243-248
    CrossrefPubMedGoogle Scholar
  • 59 Bangarulingam SY, Gossard AA, Petersen BT. et al. Complications of endoscopic retrograde cholangiopancreatography in primary sclerosing cholangitis. Am J Gastroenterol 2009; 104: 855-860
    CrossrefPubMedGoogle Scholar
  • 60 Alkhatib AA, Hilden K, Adler DG. Comorbidities, sphincterotomy, and balloon dilation predict post-ERCP adverse events in PSC patients: operator experience is protective. Dig Dis Sci 2011; 56: 3685-3688
    CrossrefPubMedGoogle Scholar
  • 61 von Seth E, Arnelo U, Enochsson L. et al. Primary sclerosing cholangitis increases the risk for pancreatitis after endoscopic retrograde cholangiopancreatography. Liver Int 2015; 35: 254-262
    CrossrefPubMedGoogle Scholar
  • 62 Etzel JP, Eng SC, Ko CW. et al. Complications after ERCP in patients with primary sclerosing cholangitis. Gastrointest Endosc 2008; 67: 643-648
    CrossrefPubMedGoogle Scholar
  • 63 Andriulli A, Loperfido S, Napolitano G. et al. Incidence rates of post-ERCP complications: a systematic survey of prospective studies. Am J Gastroenterol 2007; 102: 1781-1788
    CrossrefPubMedGoogle Scholar
  • 64 Lombard M, Farrant M, Karani J. et al. Improving biliary-enteric drainage in primary sclerosing cholangitis: experience with endoscopic methods. Gut 1991; 32: 1364-1368
    CrossrefPubMedGoogle Scholar
  • 65 Stiehl A, Rudolph G, Sauer P. et al. Efficacy of ursodeoxycholic acid treatment and endoscopic dilation of major duct stenoses in primary sclerosing cholangitis. An 8-year prospective study. J Hepatol 1997; 26: 560-566
    CrossrefPubMedGoogle Scholar
  • 66 Linder S, Soderlund C. Endoscopic therapy in primary sclerosing cholangitis: outcome of treatment and risk of cancer. Hepatogastroenterology 2001; 48: 387-392
    PubMedGoogle Scholar
  • 67 Moreno Luna LE, Gores GJ. Advances in the diagnosis of cholangiocarcinoma in patients with primary sclerosing cholangitis. Liver Transpl 2006; 12 (Suppl. 02) S15-19
    CrossrefPubMedGoogle Scholar
  • 68 Tse F, Yuan Y, Moayyedi P. et al. Guidewire-assisted cannulation of the common bile duct for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Cochrane Database Syst Rev Dec 2012; DOI: 10.1002/14651858.CD009662.pub2.
    PubMedGoogle Scholar
  • 69 Dumonceau JM, Andriulli A, Elmunzer BJ. et al. Prophylaxis of post-ERCP pancreatitis: European Society of Gastrointest Endosc (ESGE) Guideline – updated June 2014. Endoscopy 2014; 46: 799-815
    Article in Thieme ConnectPubMedGoogle Scholar
  • 70 Shi N, Deng L, Altaf K. et al. Rectal indomethacin for the prevention of post-ERCP pancreatitis: A meta-analysis of randomized controlled trials. Turk J Gastroenterol 2015; 26: 236-240
    CrossrefPubMedGoogle Scholar
  • 71 Andrade-Davila VF, Chavez-Tostado M, Davalos-Cobian C. et al. Rectal indomethacin versus placebo to reduce the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography: results of a controlled clinical trial. BMC Gastroenterol 2015; 15: 85
    CrossrefPubMedGoogle Scholar
  • 72 Nicolas-Perez D, Castilla-Rodriguez I, Gimeno-Garcia AZ. et al. Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a cost-effectiveness analysis. Pancreas 2015; 44: 204-210
    CrossrefPubMedGoogle Scholar
  • 73 Brand M, Bizos D, O’Farrell Jr P. Antibiotic prophylaxis for patients undergoing elective endoscopic retrograde cholangiopancreatography. Cochrane Database Syst Rev 2010; DOI: 10.1002/14651858.CD007345.pub2.
    PubMedGoogle Scholar
  • 74 Khashab MA, Chithadi KV, Acosta RD. et al. Antibiotic prophylaxis for GI endoscopy. Gastrointest Endosc 2015; 81: 81-89
    CrossrefPubMedGoogle Scholar
  • 75 Negm AA, Schott A, Vonberg RP. et al. Routine bile collection for microbiological analysis during cholangiography and its impact on the management of cholangitis. Gastrointest Endosc 2010; 72: 284-291
    CrossrefPubMedGoogle Scholar
  • 76 Razumilava N, Gores GJ, Lindor KD. Cancer surveillance in patients with primary sclerosing cholangitis. Hepatology 2011; 54: 1842-1852
    CrossrefPubMedGoogle Scholar
  • 77 Weismüller TJ, Trivedi PJ, Bergquist A. et al. Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis. Gastroenterology 2017; Mar 5. pii: S0016-5085(17)30236-6 DOI: 10.1053/j.gastro.2017.02.038. [Epub ahead of print]
    PubMedGoogle Scholar
  • 78 Boonstra K, Weersma RK, van Erpecum KJ. et al. Population-based epidemiology, malignancy risk, and outcome of primary sclerosing cholangitis. Hepatology 2013; 58: 2045-2055
    CrossrefPubMedGoogle Scholar
  • 79 de Valle MB, Bjornsson E, Lindkvist B. Mortality and cancer risk related to primary sclerosing cholangitis in a Swedish population-based cohort. Liver Int 2012; 32: 441-448
    PubMedGoogle Scholar
  • 80 Boberg KM, Bergquist A, Mitchell S. et al. Cholangiocarcinoma in primary sclerosing cholangitis: risk factors and clinical presentation. Scand J Gastroenterol 2002; 37: 1205-1211
    CrossrefPubMedGoogle Scholar
  • 81 Levy C, Lymp J, Angulo P. et al. The value of serum CA 19-9 in predicting cholangiocarcinomas in patients with primary sclerosing cholangitis. Dig Dis Sci 2005; 50: 1734-1740
    CrossrefPubMedGoogle Scholar
  • 82 Sinakos E, Saenger AK, Keach J. et al. Many patients with primary sclerosing cholangitis and increased serum levels of carbohydrate antigen 19-9 do not have cholangiocarcinoma. Clin Gastroenterol Hepatol 2011; 9: 434-439e1
    CrossrefPubMedGoogle Scholar
  • 83 Venkatesh PG, Navaneethan U, Shen B. et al. Increased serum levels of carbohydrate antigen 19-9 and outcomes in primary sclerosing cholangitis patients without cholangiocarcinoma. Dig Dis Sci 2013; 58: 850-857
    CrossrefPubMedGoogle Scholar
  • 84 Wannhoff A, Hov JR, Folseraas T. et al. FUT2 and FUT3 genotype determines CA19-9 cut-off values for detection of cholangiocarcinoma in patients with primary sclerosing cholangitis. J Hepatol 2013; 59: 1278-1284
    CrossrefPubMedGoogle Scholar
  • 85 DeOliveira ML, Cunningham SC, Cameron JL. et al. Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution. Ann Surg 2007; 245: 755-762
    CrossrefPubMedGoogle Scholar
  • 86 Ponsioen CY, Vrouenraets SM, van Milligen de Wit AW. et al. Value of brush cytology for dominant strictures in primary sclerosing cholangitis. Endoscopy 1999; 31: 305-309
    Article in Thieme ConnectPubMedGoogle Scholar
  • 87 Lindberg B, Arnelo U, Bergquist A. et al. Diagnosis of biliary strictures in conjunction with endoscopic retrograde cholangiopancreaticography, with special reference to patients with primary sclerosing cholangitis. Endoscopy 2002; 34: 909-916
    Article in Thieme ConnectPubMedGoogle Scholar
  • 88 Siqueira E, Schoen RE, Silverman W. et al. Detecting cholangiocarcinoma in patients with primary sclerosing cholangitis. Gastrointest Endosc 2002; 56: 40-47
    CrossrefPubMedGoogle Scholar
  • 89 Lal A, Okonkwo A, Schindler S. et al. Role of biliary brush cytology in primary sclerosing cholangitis. Acta Cytol 2004; 48: 9-12
    CrossrefPubMedGoogle Scholar
  • 90 Furmanczyk PS, Grieco VS, Agoff SN. Biliary brush cytology and the detection of cholangiocarcinoma in primary sclerosing cholangitis: evaluation of specific cytomorphologic features and CA19-9 levels. Am J Clin Pathol 2005; 124: 355-360
    CrossrefPubMedGoogle Scholar
  • 91 Boberg KM, Jebsen P, Clausen OP. et al. Diagnostic benefit of biliary brush cytology in cholangiocarcinoma in primary sclerosing cholangitis. J Hepatol 2006; 45: 568-574
    CrossrefPubMedGoogle Scholar
  • 92 Moff SL, Clark DP, Maitra A. et al. Utility of bile duct brushings for the early detection of cholangiocarcinoma in patients with primary sclerosing cholangitis. J Clin Gastroenterol 2006; 40: 336-341
    CrossrefPubMedGoogle Scholar
  • 93 Moreno Luna LE, Kipp B, Halling KC. et al. Advanced cytologic techniques for the detection of malignant pancreatobiliary strictures. Gastroenterology 2006; 131: 1064-1072
    CrossrefPubMedGoogle Scholar
  • 94 Halme L, Arola J, Numminen K. et al. M. Biliary dysplasia in patients with primary sclerosing cholangitis: additional value of DNA ploidity. Liver Int 2012; 32: 783-789
    CrossrefPubMedGoogle Scholar
  • 95 Trikudanathan G, Navaneethan U, Njei B. et al. Diagnostic yield of bile duct brushings for cholangiocarcinoma in primary sclerosing cholangitis: a systematic review and meta-analysis. Gastrointest Endosc 2014; 79: 783-789
    CrossrefPubMedGoogle Scholar
  • 96 Navaneethan U, Njei B, Venkatesh PG. et al. Fluorescence in situ hybridization for diagnosis of cholangiocarcinoma in primary sclerosing cholangitis: a systematic review and meta-analysis. Gastrointest Endosc 2014; 79: 943-950e3
    CrossrefPubMedGoogle Scholar
  • 97 Navaneethan U, Njei B, Lourdusamy V. et al. Comparative effectiveness of biliary brush cytology and intraductal biopsy for detection of malignant biliary strictures: a systematic review and meta-analysis. Gastrointest Endosc 2015; 81: 168-176
    CrossrefPubMedGoogle Scholar
  • 98 Walker SL, McCormick PA. Diagnosing cholangiocarcinoma in primary sclerosing cholangitis: an “evidence based radiology” review. Abdom Imaging 2008; 33: 14-17
    CrossrefPubMedGoogle Scholar
  • 99 Karlsen TH, Vesterhus M, Boberg KM. Review article: controversies in the management of primary biliary cirrhosis and primary sclerosing cholangitis. Aliment Pharmacol Ther 2014; 39: 282-301
    CrossrefPubMedGoogle Scholar
  • 100 Nanda A, Brown JM, Berger SH. et al. Triple modality testing by endoscopic retrograde cholangiopancreatography for the diagnosis of cholangiocarcinoma. Therap Adv Gastroenterol 2015; 8: 56-65
    CrossrefPubMedGoogle Scholar
  • 101 Fukuda Y, Tsuyuguchi T, Sakai Y. et al. Diagnostic utility of peroral cholangioscopy for various bile-duct lesions. Gastrointest Endosc 2005; 62: 374-382
    CrossrefPubMedGoogle Scholar
  • 102 Kawakami H, Kuwatani M, Etoh K. et al. Endoscopic retrograde cholangiography versus peroral cholangioscopy to evaluate intraepithelial tumor spread in biliary cancer. Endoscopy 2009; 41: 959-964
    Article in Thieme ConnectPubMedGoogle Scholar
  • 103 Nishikawa T, Tsuyuguchi T, Sakai Y. et al. Comparison of the diagnostic accuracy of peroral video-cholangioscopic visual findings and cholangioscopy-guided forceps biopsy findings for indeterminate biliary lesions: a prospective study. Gastrointest Endosc 2013; 77: 219-226
    CrossrefPubMedGoogle Scholar
  • 104 Arnelo U, von Seth E, Bergquist A. Prospective evaluation of the clinical utility of single-operator peroral cholangioscopy in patients with primary sclerosing cholangitis. Endoscopy 2015; 47: 696-702
    Article in Thieme ConnectPubMedGoogle Scholar
  • 105 Smith MP, Loe RH. Sclerosing cholangitis; review of recent case reports and associated diseases and four new cases. Am J Surg 1965; 110: 239-246
    CrossrefPubMedGoogle Scholar
  • 106 Broome U, Lindberg G, Lofberg R. Primary sclerosing cholangitis in ulcerative colitis – a risk factor for the development of dysplasia and DNA aneuploidy?. Gastroenterology 1992; 102: 1877-1880
    CrossrefPubMedGoogle Scholar
  • 107 Broome U, Lofberg R, Lundqvist K. et al. Subclinical time span of inflammatory bowel disease in patients with primary sclerosing cholangitis. Dis Colon Rectum 1995; 38: 1301-1305
    CrossrefPubMedGoogle Scholar
  • 108 Broome U, Lofberg R, Veress B. et al. Primary sclerosing cholangitis and ulcerative colitis: evidence for increased neoplastic potential. Hepatology 1995; 22: 1404-1408
    PubMedGoogle Scholar
  • 109 Soetikno RM, Lin OS, Heidenreich PA. et al. Increased risk of colorectal neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis: a meta-analysis. Gastrointest Endosc 2002; 56: 48-54
    CrossrefPubMedGoogle Scholar
  • 110 Broome U, Bergquist A. Primary sclerosing cholangitis, inflammatory bowel disease, and colon cancer. Semin Liver Dis 2006; 26: 31-41
    Article in Thieme ConnectPubMedGoogle Scholar
  • 111 Lindor KD, Kowdley KV, Harrison ME. et al. ACG Clinical Guideline: Primary sclerosing cholangitis. Am J Gastroenterol 2015; 110: 646-659 ; quiz 60
    CrossrefPubMedGoogle Scholar
  • 112 Annese V, Daperno M, Rutter MD. et al. European evidence based consensus for endoscopy in inflammatory bowel disease. J Crohns Colitis 2013; 7: 982-1018
    CrossrefPubMedGoogle Scholar
  • 113 Tsaitas C, Semertzidou A, Sinakos E. Update on inflammatory bowel disease in patients with primary sclerosing cholangitis. World J Hepatol 2014; 6: 178-187
    CrossrefPubMedGoogle Scholar
  • 114 Claessen MM, Lutgens MW, van Buuren HR. et al. More right-sided IBD-associated colorectal cancer in patients with primary sclerosing cholangitis. Inflamm Bowel Dis 2009; 15: 1331-1336
    CrossrefPubMedGoogle Scholar
  • 115 Vera A, Gunson BK, Ussatoff V. et al. Colorectal cancer in patients with inflammatory bowel disease after liver transplantation for primary sclerosing cholangitis. Transplantation 2003; 75: 1983-1988
    CrossrefPubMedGoogle Scholar
  • 116 Jorgensen KK, Grzyb K, Lundin KE. et al. Inflammatory bowel disease in patients with primary sclerosing cholangitis: clinical characterization in liver transplanted and nontransplanted patients. Inflamm Bowel Dis 2012; 18: 536-545
    CrossrefPubMedGoogle Scholar
  • 117 Fausa O, Schrumpf E, Elgjo K. Relationship of inflammatory bowel disease and primary sclerosing cholangitis. Semin Liver Dis 1991; 11: 31-39
    Article in Thieme ConnectPubMedGoogle Scholar
  • 118 Kaminski MF, Hassan C, Bisschops R. et al. Advanced imaging for detection and differentiation of colorectal neoplasia: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy 2014; 46: 435-449
    Article in Thieme ConnectPubMedGoogle Scholar
  • 119 Subramanian V, Mannath J, Ragunath K. et al. Meta-analysis: the diagnostic yield of chromoendoscopy for detecting dysplasia in patients with colonic inflammatory bowel disease. Aliment Pharmacol Ther 2011; 33: 304-312
    CrossrefPubMedGoogle Scholar
  • 120 Rutter MD, Saunders BP, Wilkinson KH. et al. Most dysplasia in ulcerative colitis is visible at colonoscopy. Gastrointest Endosc 2004; 60: 334-339
    CrossrefPubMedGoogle Scholar
  • 121 Rubin DT, Rothe JA, Hetzel JT. et al. Are dysplasia and colorectal cancer endoscopically visible in patients with ulcerative colitis?. Gastrointest Endosc 2007; 65: 998-1004
    CrossrefPubMedGoogle Scholar
  • 122 Riddell RH, Goldman H, Ransohoff DF. et al. Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Human Pathol 1983; 14: 931-968
    CrossrefPubMedGoogle Scholar
  • 123 Connell WR, Lennard-Jones JE, Williams CB. et al. Factors affecting the outcome of endoscopic surveillance for cancer in ulcerative colitis. Gastroenterology 1994; 107: 934-944
    CrossrefPubMedGoogle Scholar
  • 124 Ullman TA, Loftus Jr EV, Kakar S. et al. The fate of low grade dysplasia in ulcerative colitis. Am J Gastroenterol 2002; 97: 922-927
    CrossrefPubMedGoogle Scholar
  • 125 Befrits R, Ljung T, Jaramillo E. et al. Low-grade dysplasia in extensive, long-standing inflammatory bowel disease: a follow-up study. Dis Colon Rectum 2002; 45: 615-620
    CrossrefPubMedGoogle Scholar
  • 126 Lim CH, Dixon MF, Vail A. et al. Ten year follow up of ulcerative colitis patients with and without low grade dysplasia. Gut 2003; 52: 1127-1132
    CrossrefPubMedGoogle Scholar