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Endoscopy 2017; 49(05): 447-455
DOI: 10.1055/s-0043-104527
Original article
© Georg Thieme Verlag KG Stuttgart · New York

Extracorporeal shock wave lithotripsy is safe and effective for pediatric patients with chronic pancreatitis

Dan Wang   *
1   Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China
,
Ya-Wei Bi   *
1   Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China
,
Jun-Tao Ji   *
2   Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China
,
Lei Xin
1   Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China
,
Jun Pan
1   Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China
,
Zhuan Liao
1   Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China
2   Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China
,
Ting-Ting Du
1   Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China
,
Jin-Huan Lin
1   Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China
,
Di Zhang
1   Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China
,
Xiang-Peng Zeng
1   Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China
,
Bo Ye
3   Department of Surgery, Jinling Hospital, Nanjing, China
,
Wen-Bin Zou
1   Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China
,
Hui Chen
2   Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China
,
Ting Xie
4   Department of Gastroenterology, Zhongda Hospital, Southeast University, Nanjing, China
,
Bai-Rong Li
5   Department of Gastroenterology, Air Force General Hospital, Beijing, China
,
Zhao-Hong Zheng
6   Department of Traditional Chinese Medicine, Jiangdu Hospital, Yangzhou, China
,
Zhao-Shen Li
1   Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China
2   Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China
,
Liang-Hao Hu
1   Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China
2   Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China
› Author Affiliations
Further Information

Publication History

submitted 23 September 2016

accepted after revision 06 February 2017

Publication Date:
12 April 2017 (online)

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Abstract

Background and aims Pancreatic extracorporeal shock wave lithotripsy (P-ESWL) is recommended as the first-line treatment for pancreatic stones. However, how well P-ESWL performs in pediatric patients remains unclear. We aimed to evaluate the safety and efficacy of P-ESWL for pediatric patients with chronic pancreatitis.

Methods This prospective observational study was conducted in patients with painful chronic pancreatitis who underwent P-ESWL. Patients aged under 18 years were included in the pediatric group; patients aged over 18 years who underwent P-ESWL in the same period were assigned to the control group. For investigation of long-term follow-up, the pediatric group were matched with patients from the control group in a 1:1 ratio. The primary outcomes were P-ESWL complications and pain relief. The secondary outcomes included: stone clearance, physical and mental health, quality of life score, and growth and developmental state.

Results From March 2011 to March 2015, P-ESWL was performed in 1135 patients (72 in the pediatric group, 1063 in the control group). No significant differences were observed in the occurrence of P-ESWL complications between the two groups (11.1 % vs. 12.8 %; P = 0.68). Among the 67 pediatric patients (93.1 %) who underwent follow-up for 3.0 years (range 1.3 – 5.2), complete pain relief was achieved in 52 patients (52 /67; 77.6 %); this value was not significantly different from that of the matched controls (55 /69; 79.7 %; P = 0.94).

Conclusions P-ESWL is safe and effective for pediatric patients with chronic pancreatitis. It can promote significant pain relief and stone clearance, and can benefit growth and development.

* Contributed equally to this study.


 

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