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Neurology International Open 2017; 01(03): E142-E147
DOI: 10.1055/s-0043-102478
Review
© Georg Thieme Verlag KG Stuttgart · New York

Transcranial Electrical Brain Stimulation

Janine Reis
1   Department of Neurology, Albert- Ludwigs-Universität Freiburg, Germany
,
Brita Fritsch
1   Department of Neurology, Albert- Ludwigs-Universität Freiburg, Germany
› Institutsangaben
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Publikationsverlauf

Publikationsdatum:
28. Juli 2017 (online)

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Abstract

Transcranial electrical brain stimulation using weak direct current (tDCS) or alternating current (tACS) is being increasingly used in clinical and experimental settings to improve cognitive and motor functions in healthy subjects as well as neurological patients. This review focuses on the therapeutic value of transcranial direct current stimulation for neurorehabilitation and provides an overview of studies addressing motor and non-motor symptoms after stroke, disorders of attention and consciousness as well as Parkinson’s disease.

Key words

noninvasive brain stimulation - stroke - neuroplasticity - neurorehabilitation
 

  • References

  • 1 Bikson M, Grossman P, Thomas C. et al. Safety of transcranial direct current stimulation: Evidence based update 2016. Brain Stimul 2016; 9: 641-661
    CrossrefPubMedGoogle Scholar
  • 2 Gellner A-K, Reis J, Fritsch B. Glia: A neglected player in non-invasive direct current brain stimulation. Front Cell Neurosci 2016; 10: 188
    PubMedGoogle Scholar
  • 3 Bindman LJ, Lippold OC, Redfearn JW. Long-lasting changes in the level of the electrical activity of the cerebral cortex produced bypolarizing currents. Nature 1962; 196: 584-585
    CrossrefPubMedGoogle Scholar
  • 4 Gartside IB. Mechanisms of sustained increases of firing rate of neurones in the rat cerebral cortex after polarization: role of protein synthesis. Nature 1968; 220: 382-383
    CrossrefPubMedGoogle Scholar
  • 5 Nitsche M, Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol 2000; 527 Pt 3 633-639
    CrossrefPubMedGoogle Scholar
  • 6 Nitsche MA, Paulus W. Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans. Neurology 2001; 57: 1899-1901
    CrossrefPubMedGoogle Scholar
  • 7 Fritsch B, Reis J, Martinowich K. et al. Direct current stimulation promotes BDNF-dependent synaptic plasticity: Potential implications for motor learning. Neuron 2010; 66: 198-204
    CrossrefPubMedGoogle Scholar
  • 8 Podda MV, Cocco S, Mastrodonato A. et al. Anodal transcranial direct current stimulation boosts synaptic plasticity and memory in mice via epigenetic regulation of Bdnf expression. Sci Rep 2016; 6: 22180
    CrossrefPubMedGoogle Scholar
  • 9 Ranieri F, Podda MV, Riccardi E. et al. Modulation of LTP at rat hippocampal CA3-CA1 synapses by direct current stimulation. J Neurophysiol 2012; 107: 1868-1880
    CrossrefPubMedGoogle Scholar
  • 10 Reis J, Schambra HM, Cohen LG. et al. Noninvasive cortical stimulation enhances motor skill acquisition over multiple days through an effect on consolidation. Proc Natl Acad Sci U S A 2009; 106: 1590-1595
    CrossrefPubMedGoogle Scholar
  • 11 Buch ER, Santarnecchi E, Antal A et al. Effects of tDCS on motor learning and memory formation: A consensus and critical position paper. bioRxiv 2016 Available at http://biorxiv.org/content/early/2016/07/18/064204.abstract
    PubMed
  • 12 Lefaucheur J-P, Antal A, Ayache SS. et al. Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS). Clin Neurophysiol 2016; 128: 56-92
    PubMedGoogle Scholar
  • 13 Cappon D, Jahanshahi M, Bisiacchi P. Value and efficacy of transcranial direct current stimulation in the cognitive rehabilitation: A critical review since 2000. Front Neurosci 2016; 10: 157
    PubMedGoogle Scholar
  • 14 Lefaucheur JP. A comprehensive database of published tDCS clinical trials (2005–2016). Clin Neurophysiol 2016; 46: 319-398
    CrossrefPubMedGoogle Scholar
  • 15 Verheyden G, Nieuwboer A, Wit LD et al. Time course of trunk, arm, leg, and functional recovery after ischemic stroke. Neurorehabil Neural Repair 2007 Available at http://www.ncbi.nlm.nih.gov/entrez/query. fcgi?cmd = Retrieve&db = PubMed&dopt = Citation&list_ uids = 17876069
    PubMed
  • 16 Kwakkel G, Kollen B, Twisk J. Impact of time on improvement of outcome after stroke. Stroke 2006; 37: 2348-2353
    CrossrefPubMedGoogle Scholar
  • 17 Flowers HL, Skoretz SA, Silver FL. et al. Poststroke aphasia frequency, recovery, and outcomes: A systematic review and meta-analysis. Arch Phys Med Rehabil 2016; 97: 2188-2201.e8
    CrossrefPubMedGoogle Scholar
  • 18 Grefkes C, Ward NS. Cortical reorganization after stroke: How much and how functional?. Neuroscientist 2014; 20: 56-70
    CrossrefPubMedGoogle Scholar
  • 19 Duque J, Hummel F, Celnik P. et al. Transcallosal inhibition in chronic subcortical stroke. Neuroimage 2005; 28: 940-946
    CrossrefPubMedGoogle Scholar
  • 20 Murase N, Duque J, Mazzocchio R. et al. Influence of interhemispheric interactions on motor function in chronic stroke. Ann Neurol 2004; 55: 400-409
    CrossrefPubMedGoogle Scholar
  • 21 Allman C, Amadi U, Winkler AM. et al. Ipsilesional anodal tDCS enhances the functional benefits of rehabilitation in patients after stroke. Sci Transl Med 2016; 8: 330re1
    CrossrefPubMedGoogle Scholar
  • 22 Mortensen J, Figlewski K, Andersen H. Combined transcranial direct current stimulation and home-based occupational therapy for upper limb motor impairment following intracerebral hemorrhage: A double-blind randomized controlled trial. Disabil Rehabil 2016; 38: 637-643
    CrossrefPubMedGoogle Scholar
  • 23 Elsner B, Kugler J, Pohl M. et al. Transcranial direct current stimulation (tDCS) for improving activities of daily living, and physical and cognitive functioning, in people after stroke. Cochrane database Syst Rev 2016; 3: CD009645
    PubMedGoogle Scholar
  • 24 Tedesco Triccas L, Burridge JH, Hughes AM. et al. Multiple sessions of transcranial direct current stimulation and upper extremity rehabilitation in stroke: A review and meta-analysis. Clin Neurophysiol 2016; 127: 946-955
    CrossrefPubMedGoogle Scholar
  • 25 Kang N, Summers JJ, Cauraugh JH. Transcranial direct current stimulation facilitates motor learning post-stroke: A systematic review and meta-analysis. J Neurol Neurosurg Psychiatry 2016; 87: 345-355
    CrossrefPubMedGoogle Scholar
  • 26 Rossi C, Sallustio F, Di Legge S. et al. Transcranial direct current stimulation of the affected hemisphere does not accelerate recovery of acute stroke patients. Eur J Neurol 2013; 20: 202-204
    CrossrefPubMedGoogle Scholar
  • 27 Di Lazzaro V, Dileone M, Capone F. et al. Immediate and late modulation of interhemipheric imbalance with bilateral transcranial direct current stimulation in acute stroke. Brain Stimul 2014; 7: 841-848
    CrossrefPubMedGoogle Scholar
  • 28 Kim SJ, Kim BK, Ko YJ. et al. Functional and histologic changes after repeated transcranial direct current stimulation in rat stroke model. J Korean Med Sci 2010; 25: 1499-1505
    CrossrefPubMedGoogle Scholar
  • 29 Yoon KJ, Oh B-M, Kim D-Y. Functional improvement and neuroplastic effects of anodal transcranial direct current stimulation (tDCS) delivered 1 day vs. 1 week after cerebral ischemia in rats. Brain Res 2012; 1452: 61-72
    CrossrefPubMedGoogle Scholar
  • 30 Peruzzotti-Jametti L, Cambiaghi M, Bacigaluppi M. et al. Safety and efficacy of transcranial direct current stimulation in acute experimental ischemic stroke. Stroke 2013; 44: 3166-3174
    CrossrefPubMedGoogle Scholar
  • 31 Notturno F, Pace M, Zappasodi F. et al. Neuroprotective effect of cathodal transcranial direct current stimulation in a rat stroke model. J Neurol Sci 2014; 342: 146-151
    CrossrefPubMedGoogle Scholar
  • 32 Braun R, Klein R, Walter HL. et al. Transcranial direct current stimulation accelerates recovery of function, induces neurogenesis and recruits oligodendrocyte precursors in a rat model of stroke. Exp Neurol 2016; 279: 127-136
    CrossrefPubMedGoogle Scholar
  • 33 Yi YG, Chun MH, Do KH. et al. The effect of transcranial direct current stimulation on neglect syndrome in stroke patients. Ann Rehabil Med 2016; 40: 223-229
    CrossrefPubMedGoogle Scholar
  • 34 Làdavas E, Giulietti S, Avenanti A. et al. a-tDCS on the ipsilesional parietal cortex boosts the effects of prism adaptation treatment in neglect. Restor Neurol Neurosci 2015; 33: 647-662
    PubMedGoogle Scholar
  • 35 Bang D-H, Bong S-Y. Effect of combination of transcranial direct current stimulation and feedback training on visuospatial neglect in patients with subacute stroke: a pilot randomized controlled trial. J Phys Ther Sci 2015; 27: 2759-2761
    CrossrefPubMedGoogle Scholar
  • 36 Torres J, Drebing D, Hamilton R. TMS and tDCS in post-stroke aphasia: Integrating novel treatment approaches with mechanisms of plasticity. Restor Neurol Neurosci 2013; 31: 501-515
    PubMedGoogle Scholar
  • 37 Monti A, Ferrucci R, Fumagalli M. et al. Transcranial direct current stimulation (tDCS) and language. J Neurol Neurosurg Psychiatry 2013; 84: 832-842
    CrossrefPubMedGoogle Scholar
  • 38 Hamilton RH, Chrysikou EG, Coslett B. Mechanisms of aphasia recovery after stroke and the role of noninvasive brain stimulation. Brain Lang 2011; 118: 40-50
    CrossrefPubMedGoogle Scholar
  • 39 Meinzer M, Darkow R, Lindenberg R. et al. Electrical stimulation of the motor cortex enhances treatment outcome in post-stroke aphasia. Brain 2016; 139: 1152-1163
    CrossrefPubMedGoogle Scholar
  • 40 Shah-Basak PP, Wurzman R, Purcell JB. et al. Fields or flows? A comparative metaanalysis of transcranial magnetic and direct current stimulation to treat post-stroke aphasia. Restor Neurol Neurosci 2016; 34: 537-558
    PubMedGoogle Scholar
  • 41 Elsner B, Kugler J, Pohl M et al. Transcranial direct current stimulation (tDCS) for improving aphasia in patients with aphasia after stroke. Cochrane database Syst Rev 2015; CD009760
    PubMed
  • 42 Giacino JT, Ashwal S, Childs N. et al. The minimally conscious state: definition and diagnostic criteria. Neurology 2002; 58: 349-353
    CrossrefPubMedGoogle Scholar
  • 43 Thibaut A, Bruno M-A, Ledoux D. et al. tDCS in patients with disorders of consciousness: Sham-controlled randomized double-blind study. Neurology 2014; 82: 1112-1118
    CrossrefPubMedGoogle Scholar
  • 44 Leśniak M, Polanowska K, Seniów J. et al. Effects of repeated anodal tDCS coupled with cognitive training for patients with severe traumatic brain injury: A pilot randomized controlled trial. J Head Trauma Rehabil 2014; 29: E20-E29
    PubMedGoogle Scholar
  • 45 Ulam F, Shelton C, Richards L. et al. Cumulative effects of transcranial direct current stimulation on EEG oscillations and attention/working memory during subacute neurorehabilitation of traumatic brain injury. Clin Neurophysiol 2015; 126: 486-496
    CrossrefPubMedGoogle Scholar
  • 46 Sacco K, Galetto V, Dimitri D. et al. Concomitant use of transcranial direct current stimulation and computer-assisted training for the rehabilitation of attention in traumatic brain injured patients: behavioral and neuroimaging results. Front Behav Neurosci 2016; 10: 57
    PubMedGoogle Scholar
  • 47 Doruk D, Gray Z, Bravo GL. et al. Effects of tDCS on executive function in Parkinson’s disease. Neurosci Lett 2014; 582: 27-31
    CrossrefPubMedGoogle Scholar
  • 48 Manenti R, Brambilla M, Benussi A. et al. Mild cognitive impairment in Parkinson’s disease is improved by transcranial direct current stimulation combined with physical therapy. Mov Disord 2016; 31: 715-724
    CrossrefPubMedGoogle Scholar
  • 49 Ferrucci R, Cortese F, Bianchi M. et al. Cerebellar and motor cortical transcranial stimulation decrease levodopa-induced dyskinesias in parkinson’s disease. Cerebellum 2016; 15: 43-47
    CrossrefPubMedGoogle Scholar
  • 50 Brittain J-S, Probert-Smith P, Aziz TZ. et al. Tremor suppression by rhythmic transcranial current stimulation. Curr Biol 2013; 23: 436-440
    PubMedGoogle Scholar
  • 51 Vosskuhl J, Strüber D, Herrmann CS. Transcranial alternating current stimulation. Entrainment and function control of neuronal networks. Nervenarzt 2015; 86: 1516-1522
    CrossrefPubMedGoogle Scholar
  • 52 Li Y, Tian X, Qian L. et al. Anodal transcranial direct current stimulation relieves the unilateral bias of a rat model of Parkinson’s disease. Conf Proc IEEE Eng Med Biol Soc 2011; 2011: 765-768
    PubMedGoogle Scholar
  • 53 Lu C, Wei Y, Hu R. et al. Transcranial direct current stimulation ameliorates behavioral deficits and reduces oxidative stress in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of parkinson’s disease. Neuromodulation 2015; 18: 442-446 discussion 447
    CrossrefPubMedGoogle Scholar
  • 54 Brunoni AR, Amadera J, Berbel B. et al. A systematic review on reporting and assessment of adverse effects associated with transcranial direct current stimulation. Int J Neuropsychopharmacol 2011; 14: 1133-1145
    CrossrefPubMedGoogle Scholar