CC BY-NC-ND 4.0 · Neurology International Open 2017; 01(02): E61-E64
DOI: 10.1055/s-0043-102208
Review
© Georg Thieme Verlag KG Stuttgart · New York

Relevance of Heart Failure in Prevention, Treatment and Prognosis of Ischemic Stroke

Karl Georg Haeusler
1   Department of Neurology, Charité – Universitätsmedizin Berlin
2   Center for Stroke Research Berlin, Charité – Universitätsmedizin Berlin
3   Atrial Fibrillation Network
,
Matthias Endres
1   Department of Neurology, Charité – Universitätsmedizin Berlin
2   Center for Stroke Research Berlin, Charité – Universitätsmedizin Berlin
4   German Center for Cardiovascular Research, Berlin
5   German Center for Neurodegenerative Diseases, Berlin
,
Wolfram Doehner
2   Center for Stroke Research Berlin, Charité – Universitätsmedizin Berlin
6   Department of Cardiology, Campus Virchow, Charité – Universitätsmedizin Berlin
› Author Affiliations
Further Information

Publication History

Publication Date:
25 April 2017 (online)

Abstract

About 1.2 million people in Germany suffer from heart failure (HF) and HF is present in about 13–29% of all patients with acute ischemic stroke. HF is a risk factor for ischemic stroke and it is accompanied by a comparably high morbidity and mortality after stroke. Only limited data are available regarding the relevance of HF in acute ischemic stroke. The hypothesis has emerged that an acute ischemic stroke may contribute to deterioration and occurrence of heart failure. Stroke prevention by oral anticoagulation is only recommended for HF patients with concomitant atrial fibrillation. This article is based on a selective literature review summarizing the present knowledge as well as current guideline recommendations and provides recommendations for clinical practice.

 
  • References

  • 1 Statistisches Bundesamt. Todesursachen in Deutschland. 2014; https://www.destatis.de/DE/Publikationen/Thematisch/Gesundheit/Todesursachen/Todesursachen2120400147004.pdf?__blob = publicationFile
  • 2 Statistisches Bundesamt. Diagnosedaten der Patienten und Patientinnen in Krankenhäusern. 2014; https://www.destatis.de/DE/Publikationen/ Thematisch/Gesundheit/Krankenhaeuser/DiagnosedatenKrankenhaus2120621147004. pdf?__blob = publicationFile
  • 3 Zarrinkoub R, Wettermark B, Wändell P. et al. The epidemiology of heart failure, based on data for 2.1 million inhabitants in Sweden. Eur J Heart Fail 2013; 15: 995-1002
  • 4 Ponikowski P, Voors AA, Anker SD. et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 2016; 18: 891-975
  • 5 Häusler KG, Laufs U, Endres M. Neurologische Aspekte bei chronischer Herzinsuffizienz. Nervenarzt 2011; 82: 733-742
  • 6 Häusler KG, Laufs U, Endres M. Chronic Heart Failure and Ischemic Stroke. Stroke 2011; 42: 2977-2982
  • 7 Häusler KG, Hellwig S, Döhner W. et al. Herzinsuffizienz als Risikofaktor für den akuten ischämischen Schlaganfall. Klinikarzt 2014; 43: 510-516
  • 8 Vemmos K, Ntaios G, Savvari P. et al. Stroke aetiology and predictors of outcome in patients with heart failure and acute stroke: A 10-year follow-up study. Eur J Heart Fail 2012; 14: 211-218
  • 9 Abdul-Rahim AH, Perez AC, Fulton RL. et al. Risk of stroke in chronic heart failure patients without atrial fibrillation: Analysis of the controlled rosuvastatin in multinational trial heart failure (CORONA) and the Gruppo Italiano per lo Studio della Sopravvivenza nell’Insufficienza Cardiaca- Heart Failure (GISSI-HF) trials. Circulation 2015; 131: 1486-1494
  • 10 Ferreira JP, Girerd N, Alshalash S. et al. Antithrombotic therapy in heart failure patients with and without atrial fibrillation: Update and future challenges. Eur Heart J 2016; 37: 2455-2464
  • 11 Kirchhof P, Benussi S, Kotecha D. et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS: The task force for the management of atrial fibrillation of the European Society of Cardiology (ESC) developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESCEndorsed by the European Stroke Organisation (ESO). Eur Heart J 2016; 37: 2893-2962
  • 12 Melgaard L, Gorst-Rasmussen A, Lane DA. et al. Assessment of the CHA2DS2-VASc score in predicting ischemic stroke, thromboembolism, and death in patients with heart failure with and without atrial fibrillation. JAMA 2015; 314: 1030-1038
  • 13 Freudenberger RS, Cheng B, Mann DL. et al. The first prognostic model for stroke and death in patients with systolic heart failure. J Cardiol 2016; 68: 100-103
  • 14 Katsanos AH, Parissis J, Frogoudaki A. et al. Heart failure and the risk of ischemic stroke recurrence: A systematic review and meta-analysis. J Neurol Sci 2016; 362: 182-187
  • 15 Hopper I, Skiba M, Krum H. Updated meta-analysis on antithrombotic therapy in patients with heart failure and sinus rhythm. Eur J Heart Fail 2013; 15: 69-78
  • 16 Pullicino PM, Qian M, Sacco RL. et al. Recurrent stroke in the warfarin versus aspirin in reduced cardiac ejection fraction (WARCEF) trial. Cerebrovasc Dis 2014; 38: 176-181
  • 17 Di Tullio MR, Qian M, Thompson JL. et al. Left ventricular ejection fraction and risk of stroke and cardiac events in heart failure: Data from the warfarin versus aspirin in reduced ejection fraction trial. Stroke 2016; 47: 2031-2037
  • 18 Lip GY, Ponikowski P, Andreotti F. et al. Thrombo-embolism and antithrombotic therapy for heart failure in sinus rhythm. A joint consensus document from the ESC Heart Failure Association and the ESC Working Group on Thrombosis. Eur J Heart Fail 2012; 14: 681-695
  • 19 Zannad F, Greenberg B, Cleland JG. et al. Rationale and design of a randomized, double-blind, event-driven, multicentre study comparing the efficacy and safety of oral rivaroxaban with placebo for reducing the risk of death, myocardial infarction or stroke in subjects with heart failure and significant coronary artery disease following an exacerbation of heart failure: The COMMANDER HF trial. Eur J Heart Fail 2015; 17: 735-742
  • 20 Xiong Q, Lau YC, Senoo K. et al. Non-vitamin K antagonist oral anticoagulants (NOACs) in patients with concomitant atrial fibrillation and heart failure: A systemic review and meta-analysis of randomized trials. Eur J Heart Fail 2015; 17: 1192-1200
  • 21 Connolly SJ, Eikelboom J, Joyner C. et al. Apixaban in patients with atrial fibrillation. N Engl J Med 2011; 364: 806-817
  • 22 Yancy CW, Jessup M, Bozkurt B. et al. 2013 ACCF/AHA guideline for the management of heart failure. J Am Coll Cardiol 2013; e147-e239
  • 23 McMurray JJ, Packer M, Desai AS. et al. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014; 371: 993-1004
  • 24 Pullicino PM, Homma S. Stroke in heart failure: Atrial fibrillation revisited?. J Stroke Cerebrovasc Dis 2010; 19: 1-2
  • 25 Abdul-Rahim AH, Fulton RL, Frank B. et al. Associations of chronic heart failure with outcome in acute ischaemic stroke patients who received systemic thrombolysis: Analysis from VISTA. Eur J Neurol 2015; 22: 163-169
  • 26 Whiteley WN, Slot KB, Fernandes P. et al. Risk factors for intracranial hemorrhage in acute ischemic stroke patients treated with recombinant tissue plasminogen activator: A systematic review and meta-analysis of 55 studies. Stroke 2012; 43: 2904-2949
  • 27 Liebeskind DS, Tomsick TA, Foster LD. et al. Collaterals at angiography and outcomes in the Interventional Management of Stroke (IMS) III trial. Stroke 2014; 45: 759-764
  • 28 Rothwell PM, Algra A, Chen Z. et al. Effects of aspirin on risk and severity of early recurrent stroke after transient ischaemic attack and ischaemic stroke: Time-course analysis of randomised trials. Lancet 2016; 388: 365-375
  • 29 Zhang S, He WB, Chen NH. Causes of death among persons who survive an acute ischemic stroke. Curr Neurol Neurosci Rep 2014; 14: 467
  • 30 Wira 3rd CR, Rivers E, Martinez-Capolino C. et al. Cardiac complications in acute ischemic stroke. West J Emerg Med 2011; 12: 414-420
  • 31 Holström A, Fu ML, Hjalmarsson C. et al. Heart dysfunction in patients with acute ischemic stroke or TIA does not predict all-cause mortality at long-term follow-up. BMC Neurology 2013; 13: 122
  • 32 Byun JI, Jung KH, Kim YD. et al. Cardiac function and outcome in patients with cardio-embolic stroke. PLoS One 2014; 9: e95277
  • 33 Kristensen SL, Jhund PS, Køber L. et al. Comparison of outcomes after hospitalization for worsening heart failure, myocardial infarction, and stroke in patients with heart failure and reduced and preserved ejection fraction. Eur J Heart Fail 2015; 17: 169-176