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Horm Metab Res 2017; 49(04): 276-285
DOI: 10.1055/s-0043-100384
Review

OPA1 in Lipid Metabolism: Function of OPA1 in Lipolysis and Thermogenesis of Adipocytes

Dinh-Toi Chu
1   Centre for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway
2   Institute for Research and Development, Duy Tan University, K7/25 Quang Trung, Danang, Vietnam
3   Faculty of Biology, Hanoi National University of Education, Hanoi, Vietnam
4   College of Food Science and Technology, Nanjing Agricultural University, Nanjing, China
,
Yang Tao
4   College of Food Science and Technology, Nanjing Agricultural University, Nanjing, China
,
Kjetil Taskén
1   Centre for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway
5   K. G. Jebsen Inflammation Research Centre; University of Oslo, Oslo, Norway
6   Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway
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Abstract

OPA1 (Optic Atrophy 1) is a mitochondrial GTPase known to regulate fission of mitochondria. It was recently also shown to locate on lipid droplets in adipocytes where it functions as an A-kinase anchoring protein (AKAP) that mediates adrenergic control of lipolysis by facilitating PKA phosphorylation of perilipin (Plin1). In brown adipocytes indirect evidence support the notion that OPA1 regulation of fission serves to increase thermogenesis, which thereby contributes to dissipation of energy. In white adipocytes, OPA1 located on lipid droplets serves as a gatekeeper to control lipolysis induced by adrenergic agonists. However, the function of OPA1 in lipolysis and thermogenesis in inducible brown adipocytes (brite/beige cells) remains elusive. Here we discuss the role of OPA1 in lipid metabolism.

Key words

OPA1 - AKAP - cAMP - lipid metabolism - brown adipocyte - white adipocyte


Publication History

Received: 22 August 2016

Accepted: 21 December 2016

Article published online:
20 April 2017

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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