Subscribe to RSS
DOI: 10.1055/s-0042-1760309
Imaging Recommendations for Diagnosis, Staging, and Management of Nasopharynx Carcinoma
Abstract
Nasopharyngeal carcinoma (NPC) is an epithelial carcinoma originating from lining of the nasopharyngeal mucosa usually at the fossa of Rosenmuller (pharyngeal recess). An early detection on endoscopy can be rewarding, however, often difficult as the tumor at the pharyngeal recess is hidden from the endoscopic view. Magnetic resonance imaging and positron emission tomography–computed tomography form the backbone of detection and spread of the carcinoma into local and distant regions. These modalities help further characterize the precise locoregional infiltration and lymph nodal involvement which aids in the planning of the surgery/chemoradiotherapy. They also help in the follow-up evaluation and further management strategies. Many research and treatment groups namely American Joint Committee on Cancer, National Comprehensive Cancer Network, American Society of Clinical Oncology, American College of Radiology, Radiological Society of North America, European Society of Radiology (iGuide), Indian Radiological & Imaging Association/Indian College of Radiology and Imaging, National Cancer Grid, etc. have devised guidelines for the optimal assessment and treatment of NPC. The present document aims at providing a comprehensive review of the clinicoradiological recommendations for the diagnosis and management of NPC based on these guidelines as well as personalized experience of the contributors.
Keywords
nasopharyngeal carcinoma - diagnosis - staging - magnetic resonance imaging - computed tomographyPublication History
Article published online:
01 March 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Abdel Khalek Abdel Razek A, King A. MRI and CT of nasopharyngeal carcinoma. AJR Am J Roentgenol 2012; 198 (01) 11-18
- 2 Chen Y-P, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J. Nasopharyngeal carcinoma. Lancet 2019; 394 (10192): 64-80
- 3 Raghupathy R, Hui EP, Chan AT. Epstein-Barr virus as a paradigm in nasopharyngeal cancer: from lab to clinic. Am Soc Clin Oncol Educ Book 2014; 34 (01) 149-153
- 4 Ung A, Chen CJ, Levine PH. et al. Familial and sporadic cases of nasopharyngeal carcinoma in Taiwan. Anticancer Res 1999; 19 (1B): 661-665
- 5 Chua MLK, Wee JTS, Hui EP, Chan ATC. Nasopharyngeal carcinoma. Lancet 2016; 387 (10022): 1012-1024
- 6 Hildesheim A, Apple RJ, Chen CJ. et al. Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan. J Natl Cancer Inst 2002; 94 (23) 1780-1789
- 7 Barnes L, Eveson JW, Sidransky D, Reichart P. eds. Pathology and Genetics of Head and Neck Tumours. Geneva, Switzerland: : IARC; 2005
- 8 Leung SF, Zee B, Ma BB. et al. Plasma Epstein-Barr viral deoxyribonucleic acid quantitation complements tumor-node-metastasis staging prognostication in nasopharyngeal carcinoma. J Clin Oncol 2006; 24 (34) 5414-5418
- 9 Lee AWM, Lydiatt WM, Colevas AD. et al. Nasopharynx. In: Amin MB. ed. AJCC Cancer Staging Manual. 8th ed. New York: Springer; 2017: 103
- 10 Saba NF, Salama JK, Beitler JJ. et al; Expert Panel on Radiation Oncology-Head and Neck Cancer. ACR appropriateness criteria® for nasopharyngeal carcinoma. Head Neck 2016; 38 (07) 979-986
- 11 NCG Guidelines Manual. Accessed March 20, 2022 https://tmc.gov.in/ncg/index.php/guidelines/draft-guidelines-2020
- 12 Colevas AD, Yom SS, Pfister DG. et al. NCCN Guidelines Insights: Head and Neck Cancers, Version 1.2018. J Natl Compr Canc Netw 2018; 16 (05) 479-490
- 13 NCCN Guidelines for patients Nasopharyngeal Cancer. Accessed March 20, 2022 https://www.nccn.org/patients/guidelines/content/PDF/hn-nasopharynx-patient.pdf
- 14 Chan KCA, Hung ECW, Woo JKS. et al. Early detection of nasopharyngeal carcinoma by plasma Epstein-Barr virus DNA analysis in a surveillance program. Cancer 2013; 119 (10) 1838-1844
- 15 Lee AWM, Ng WT, Chan LLK. et al. Evolution of treatment for nasopharyngeal cancer–success and setback in the intensity-modulated radiotherapy era. Radiother Oncol 2014; 110 (03) 377-384
- 16 King AD, Vlantis AC, Bhatia KSS. et al. Primary nasopharyngeal carcinoma: diagnostic accuracy of MR imaging versus that of endoscopy and endoscopic biopsy. Radiology 2011; 258 (02) 531-537
- 17 King AD, Lam WW, Leung SF, Chan YL, Teo P, Metreweli C. MRI of local disease in nasopharyngeal carcinoma: tumour extent vs tumour stage. Br J Radiol 1999; 72 (860) 734-741
- 18 Chong VF, Fan YF, Khoo JB. Nasopharyngeal carcinoma with intracranial spread: CT and MR characteristics. J Comput Assist Tomogr 1996; 20 (04) 563-569
- 19 King AD, Vlantis AC, Tsang RKY. et al. Magnetic resonance imaging for the detection of nasopharyngeal carcinoma. AJNR Am J Neuroradiol 2006; 27 (06) 1288-1291
- 20 King AD, Ahuja AT, Leung SF. et al. Neck node metastases from nasopharyngeal carcinoma: MR imaging of patterns of disease. Head Neck 2000; 22 (03) 275-281
- 21 Ng SH, Chang JT, Chan SC. et al. Nodal metastases of nasopharyngeal carcinoma: patterns of disease on MRI and FDG PET. Eur J Nucl Med Mol Imaging 2004; 31 (08) 1073-1080
- 22 Chong VF, Fan YF, Khoo JB. Retropharyngeal lymphadenopathy in nasopharyngeal carcinoma. Eur J Radiol 1995; 21 (02) 100-105
- 23 Som PM, Brandwein MS. Lymph nodes. In: Som PM, Curtin HD. eds. Head and Neck Imaging. 4th ed. Vol. 2. Missouri, USA: : Mosby Inc; 2003: 1910-1911
- 24 Som PM. Detection of metastasis in cervical lymph nodes: CT and MR criteria and differential diagnosis. AJR Am J Roentgenol 1992; 158 (05) 961-969
- 25 King AD, Tse GM, Ahuja AT. et al. Necrosis in metastatic neck nodes: diagnostic accuracy of CT, MR imaging, and US. Radiology 2004; 230 (03) 720-726
- 26 Teo PM, Kwan WH, Lee WY, Leung SF, Johnson PJ. Prognosticators determining survival subsequent to distant metastasis from nasopharyngeal carcinoma. Cancer 1996; 77 (12) 2423-2431
- 27 Chang JT, Chan SC, Yen TC. et al. Nasopharyngeal carcinoma staging by (18)F-fluorodeoxyglucose positron emission tomography. Int J Radiat Oncol Biol Phys 2005; 62 (02) 501-507
- 28 Pfister DG, Spencer S, Adelstein D. et al. Head and Neck Cancers, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 2020; 18 (07) 873-898
- 29 Comoretto M, Balestreri L, Borsatti E, Cimitan M, Franchin G, Lise M. Detection and restaging of residual and/or recurrent nasopharyngeal carcinoma after chemotherapy and radiation therapy: comparison of MR imaging and FDG PET/CT. Radiology 2008; 249 (01) 203-211
- 30 Offiah C, Hall E. Post-treatment imaging appearances in head and neck cancer patients. Clin Radiol 2011; 66 (01) 13-24
- 31 Chong VF, Fan YF. Meningeal infiltration in recurrent nasopharyngeal carcinoma. Australas Radiol 2000; 44 (01) 23-27