PDF herunterladen
Homeopathy 2023; 112(04): 275-279
DOI: 10.1055/s-0042-1759847
Clinical Case Report

Action of Folliculinum 6cH on Folliculogenesis in the Snake Python Regius (Shaw, 1802) – Two Case Reports

Melina Castilho de Souza Balbueno 
1   Department of Veterinary Medicine and Animal Welfare, University of Santo Amaro, São Paulo, Brazil
2   HD Science School, São Caetano do Sul, São Paulo, Brazil
,
Jéssica Amâncio Martins
1   Department of Veterinary Medicine and Animal Welfare, University of Santo Amaro, São Paulo, Brazil
,
Cidéli de Paula Coelho
1   Department of Veterinary Medicine and Animal Welfare, University of Santo Amaro, São Paulo, Brazil
2   HD Science School, São Caetano do Sul, São Paulo, Brazil
› Institutsangaben
› Weitere Informationen
    Lizenzen und Reprints

Abstract

Background Folliculinum is a homeopathic sarcode medication that is mainly used for regulating the estrous cycle and reproductive function. In snakes, it is common to observe low frequencies of reproduction. Ovulation is related to follicular size and morphology, and follicle homogeneity may indicate the absence of problems such as dystocia (egg retention) or follicular stasis.

Objective The objective of the present study was to report on follicular stage changes in two ball pythons, Python regius (Shaw, 1802), which were treated using Folliculinum 6cH in a zoological park setting.

Methods Two female pythons – one weighing 2.8 kg, the other weighing 2.5 kg, and neither with a history of reproduction – were examined by ultrasound to enable viewing of ovarian follicles in different phases and sizes. Folliculinum 6cH, two globules diluted in 200 mL of water, was administered, targeted to the eyes and nostril regions.

Results Even given the slow metabolism of reptiles, ultrasound revealed an improvement in follicle homogeneity between 6 and 15 days after the start of homeopathy in both snakes; there was also improved weight gain in both animals. The MOdified NARanjo Criteria for Homeopathy (MONARCH) score was +8 in each of the cases, suggesting a causal relationship between the use of homeopathic medicine and clinical outcome.

Conclusion Folliculinum 6cH may have promoted stabilization of follicle size and enabled folliculogenesis in two ball pythons.

Keywords

homeopathy - snakes - follicular atresia - reproduction

Supplementary Material



Publikationsverlauf

Eingereicht: 04. Dezember 2021

Angenommen: 05. Oktober 2022

Artikel online veröffentlicht:
13. Februar 2023

© 2023. Faculty of Homeopathy. This article is published by Thieme.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Soldatov AA, Avdeeva JI, Kryuchkov NA, Skosyreva ES. Safety concerns of biosimilar hormone products. Curr Med Res Opin 2019; 35: 1003-1009
    CrossrefPubMedGoogle Scholar
  • 2 Kirtland KA. . The efficacy of folliculinum in the treatment of premenstrual tension [Masters dissertation]; 1994, at: https://openscholar.dut.ac.za/bitstream/10321/2747/5/kirtland_1995.pdf
    PubMed
  • 3 Legros MS. Utilización de la homeopatía en endocrinología ginecológica. Uso terapéutico de las hormonas diluidas y dinamizadas. Rev Medica Homeopat 2010; 3: 9-13
    PubMedGoogle Scholar
  • 4 Danno K, Colas A, Terzan L, Bordet MF. Homeopathic treatment of premenstrual syndrome: a case series. Homeopathy 2013; 102: 59-65
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 5 Pyron RA, Reynolds RG, Burbrink FT. A taxonomic revision of boas (Serpentes: Boidae). Zootaxa 2014; 3846: 249-260
    CrossrefPubMedGoogle Scholar
  • 6 de Oliveira Lima T, Saldanha A, Myller G, Eleuterio NF, de Almeida EC. Captive reproductive management of Boa constrictor snake and other Boidae. Paper presented at: Anais do XXIII Congresso Brasileiro de Reprodução Animal (CBRA-2019); Gramado, RS, May 15–17; 2019
    PubMedGoogle Scholar
  • 7 Gomes NMB, Puorto G, Buononato MA, Ribeiro MFM. Atlas anatômico de Boa constrictor Linnaeus, 1758 (serpente, boidae). Dissertation of Instituto Butantan; 1989:1–59
    PubMedGoogle Scholar
  • 8 Global Biodiversity Information Facility Secretariat. GBIF backbone taxonomy. Python regius (Shaw, 1802). Accessed June 22, 2022, at https://www.gbif.org/species/2465380
    PubMedGoogle Scholar
  • 9 Madsen T, Shine R. Determinants of reproductive output in female water Pythons (Liasis fuscus: Pythonidae). Herpetologica 1996; 52: 146-159
    PubMedGoogle Scholar
  • 10 Walls JG. The Living Pythons: A Complete Guide to the Pythons of the World. Neptune City, New Jersey: TFH Publications; 1998
    Google Scholar
  • 11 Stahlschmidt Z, Brashears J, Denardo D. The use of ultrasonography to assess reproductive investment and output in pythons. Biol J Linn Soc Lond 2011; 103: 772-778
    CrossrefPubMedGoogle Scholar
  • 12 Martins NB, Ferreira LAR, Pinto NNR. et al. Ultrasonographic characterization of the organs in the middle third and caudal coelomic cavity of snakes in the Boidae family. Pesq Vet Bras 2021; 41: e06557
    CrossrefPubMedGoogle Scholar
  • 13 Kolesnikovas CKM, Grego KF, Albuquerque LCR. Ordem Squamata – Subordem Ophidia (Serpente). Tratado de animais selvagens medicina veterinária. São Paulo: Roca; 2007. :68–85
    Google Scholar
  • 14 Garcia VC, de Almeida-Santos SM. Reproductive cycles of neotropical boid snakes evaluated by ultrasound. Zoo Biol 2022; 41: 74-83
    CrossrefPubMedGoogle Scholar
  • 15 DeNardo DF, Autumn K. Effect of male presence on reproductive activity in captive female blood pythons, Python curtus . Copeia 2001; 1138-1141
    CrossrefPubMedGoogle Scholar
  • 16 Wu SH, Tang HP, Wang HC. et al. Year-long ultrasonography observation of follicular features in captive yellow-margined box (Cuora flavomarginata) from Taiwan. Taiwan Shouyixue Zazhi 2019; 45: 119-128
    PubMedGoogle Scholar
  • 17 Sykes IV JM. Updates and practical approaches to reproductive disorders in reptiles. Vet Clin North Am Exot Anim Pract 2010; 13: 349-373
    CrossrefPubMedGoogle Scholar
  • 18 Kaipia A, Hsueh AJ. Regulation of ovarian follicle atresia. Annu Rev Physiol 1997; 59: 349-363
    CrossrefPubMedGoogle Scholar
  • 19 Correa PG. Monitoramento e estudos moleculares de ovos atrésicos de serpentes do gênero Bothrops. [Doctorate dissertation]. Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo; 2019
    PubMedGoogle Scholar
  • 20 Lamba CD, Gupta VK, van Haselen R. et al. Evaluation of the Modified Naranjo Criteria for assessing causal attribution of clinical outcome to homeopathic intervention as presented in case reports. Homeopathy 2020; 109: 191-197
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 21 van Haselen RA. Homeopathic clinical case reports: development of a supplement (HOM-CASE) to the CARE clinical case reporting guideline. Complement Ther Med 2016; 25: 78-85
    CrossrefPubMedGoogle Scholar
  • 22 Di Girolamo N, Selleri P. Reproductive disorders in snakes. Vet Clin North Am Exot Anim Pract 2017; 20: 391-409
    CrossrefPubMedGoogle Scholar
  • 23 Damasceno KNM, de Sá NAR, Tetaping GM. et al. Ultra-diluted Folliculinum 6 cH impairs ovine oocyte viability and maturation after in vitro culture. Anim Reprod 2020; 17: e20190100
    CrossrefPubMedGoogle Scholar
  • 24 de Lima LF, Rubessa M, Rocha RMP. et al. High diluted and dynamised follicle stimulating hormone modulates steroid production in isolated porcine preantral follicles cultured in vitro . Homeopathy 2017; 106: 87-92
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 25 Melo TCS, Coelho CP, Summa J. et al. Lachesis muta e Folliculinum na regulação do ciclo estral de onça-parda (Puma concolor). Paper presented at: XXIX Encontro e XXIII Congresso ABRAVAS, October 5–9, 2021
    PubMedGoogle Scholar
  • 26 Coelho C, Von Ancken ACB. Uso da homeopatia na medicina clínica e preventiva de animais selvagens. Boletim técnico ABRAVAS Brasil, ano III, n°32 - Mar, 2019
    PubMedGoogle Scholar
  • 27 Toudonou CA. Ball python regius (Shaw 1802). CITES, Case Species Rep; 2015. :1–8
    Google Scholar
  • 28 Shine R, Ambariyanto, Harlow PS. Mumpuni. Reticulated pythons in Sumatra: biology, harvesting and sustainability. Biol Conserv 1999; 87: 349-357
    CrossrefPubMedGoogle Scholar
  • 29 Kistin SJ, Newman AD. Induction of labor with homeopathy: a case report. J Midwifery Womens Health 2007; 52: 303-307
    CrossrefPubMedGoogle Scholar
  • 30 Lamba P, Sharma D, Sinnarkar VV. Polycystic ovarian syndrome treated with individualized homeopathy: a case report. Altern Ther Health Med 2022; 28: AT6802
    PubMedGoogle Scholar
  • 31 Parveen S, Das S. Homeopathic treatment in patients with polycystic ovarian syndrome: a case series. Homeopathy 2021; 110: 186-193
    PubMedGoogle Scholar
  • 32 Soto FRM, Vuaden ER, Coelho CP. et al. Reproductive performance of sows inseminated with diluted semen treated with homeopathic medicine. Int J High Dilution Res 2010; 9: 51-57
    CrossrefPubMedGoogle Scholar