Download PDF
CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2023; 27(04): e608-e612
DOI: 10.1055/s-0042-1758216
Original Research

Correlation of Tinnitus Severity Index and Tinnitus Handicap Inventory with Hematological Parameters in Patients with Subjective Tinnitus

Demet Yazici 
1   Department of Otorhinolaryngology, Adana City Training and Research Hospital, Adana, Turkey.
,
Mehmet Celalettin Cihan 
2   Department of Audiology, Cappadocia University, Nevşehir, Turkey.
› Author Affiliations
› Further Information
Also available at
   Permissions and Reprints

Abstract

Introduction Tinnitus etiopathogenesis is still unclear and treatment options are controversial despite current advances in medicine.

Objectives To analyze the correlation between patients' symptom scores, systemic inflammation, and trombosis biomarkers.

Methods In this prospective study, we evaluated the degree of complaints of subjective tinnitus patients with the tinnitus severity index (TSI) and tinnitus handicap inventory (THI), and correlated these symptom scores with hematological parameters such as the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), mean thrombocyte volume (MPV), and platelet distribution width (PDW).

Results A total of 44 patients with subjective tinnitus, 25 (56.8%) men and 19 (43.2%) women, were included in this study. The mean age of the patients was 42.3 ± 14.8 years. When the correlation between TSI and NLR, PLR, PDW, and MPV values of the patients were analyzed, no statistically significant correlation was found between TSI, NLR, and PLR (p > 0.05). However, there was a statistically weak positive correlation between TSI, MPV, and PDW.(p < 0.05). When the correlation between THI and NLR, PLR, PDW, and MPV values of the patients were analyzed, no statistically significant correlation was found between THI, NLR, and PLR (p > 0.05). There was a statistically weak positive correlation between THI, MPV, and PDW (p < 0.05).

Conclusion We were unable to detect any relationship between systemic inflammation markers (NLR and PLR) and symptom scores, but a weakly positive correlation was observed between thrombosis markers (MPV and PDW) and symptom scores, and as the subclinical thrombosis markers elevated, so did the symptom scores.

Keywords

tinnitus - subjective tinnitus - correlation - inflammation - thrombosis

Financial Disclosure

None.




Publication History

Received: 14 June 2022

Accepted: 01 August 2022

Article published online:
23 October 2023

© 2023. Fundação Otorrinolaringologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil

 

  • References

  • 1 Baguley D, McFerran D, Hall D. Tinnitus. Lancet 2013; 382 (9904): 1600-1607
    CrossrefPubMedGoogle Scholar
  • 2 Raj-Koziak D, Gos E, Swierniak W, Skarzynski H, Skarzynski PH. Prevalence of tinnitus in a sample of 43,064 children in Warsaw, Poland. Int J Audiol 2021; 60 (08) 614-620
    CrossrefPubMedGoogle Scholar
  • 3 Zahorec R. Ratio of neutrophil to lymphocyte counts–rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 2001; 102 (01) 5-14
    PubMedGoogle Scholar
  • 4 Luke D. The Reaction of the White Blood Cells at Parturition in the Sow. Br Vet J 1953; 109 (06) 241-244
    CrossrefGoogle Scholar
  • 5 Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010; 14 (01) 28-32
    PubMedGoogle Scholar
  • 6 Mahidhara R, Billiar TR. Apoptosis in sepsis. Crit Care Med 2000; 28 (4, Suppl) N105-N113
    CrossrefPubMedGoogle Scholar
  • 7 Menges T, Engel J, Welters I. et al. Changes in blood lymphocyte populations after multiple trauma: association with posttraumatic complications. Crit Care Med 1999; 27 (04) 733-740
    CrossrefPubMedGoogle Scholar
  • 8 Walsh SR, Cook EJ, Goulder F, Justin TA, Keeling NJ. Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol 2005; 91 (03) 181-184
    CrossrefPubMedGoogle Scholar
  • 9 Gibson PH, Croal BL, Cuthbertson BH. et al. Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting. Am Heart J 2007; 154 (05) 995-1002
    CrossrefPubMedGoogle Scholar
  • 10 Dahlen B, Schulz A, Göbel S. et al. The impact of platelet indices on clinical outcome in heart failure: results from the MyoVasc study. ESC Heart Fail 2021; 8 (04) 2991-3001
    CrossrefPubMedGoogle Scholar
  • 11 Lee HM, Han KD, Kong SK. et al. Epidemiology of Clinically Significant Tinnitus: A 10-Year Trend From Nationwide Health Claims Data in South Korea. Otol Neurotol 2018; 39 (06) 680-687
    CrossrefPubMedGoogle Scholar
  • 12 Lippi G, Henry BM, Favaloro EJ. Mean Platelet Volume Predicts Severe COVID-19 Illness. Semin Thromb Hemost 2021; 47 (04) 456-459
    Article in Thieme ConnectPubMedGoogle Scholar
  • 13 Cetin M, Bakirci EM, Baysal E. et al. Increased platelet distribution width is associated with ST-segment elevation myocardial infarction and thrombolysis failure. Angiology 2014; 65 (08) 737-743
    CrossrefPubMedGoogle Scholar
  • 14 Oğuz S. Relationship between First Values of Red Cell Distribution Width, Mean Platelet Volume, Platelet Distribution Width, and Hospital Mortality in Acute Deep Venous Thrombosis. J Coll Physicians Surg Pak 2021; 30 (04) 379-382
    PubMedGoogle Scholar
  • 15 Ruiyan W, Bin X, Jianhua D, Lei Z, Dehua G, Tang Z. Platelet Distribution Width and Mortality in Hemodialysis Patients. Evid Based Complement Alternat Med 2021; 2021: 6633845
    CrossrefPubMedGoogle Scholar
  • 16 Bhatt JM, Lin HW, Bhattacharyya N. Prevalence, Severity, Exposures, and Treatment Patterns of Tinnitus in the United States. JAMA Otolaryngol Head Neck Surg 2016; 142 (10) 959-965
    CrossrefPubMedGoogle Scholar
  • 17 Dawes P, Newall J, Stockdale D, Baguley DM. Natural history of tinnitus in adults: a cross-sectional and longitudinal analysis. BMJ Open 2020; 10 (12) e041290
    CrossrefPubMedGoogle Scholar
  • 18 Wu BP, Searchfield G, Exeter DJ, Lee A. Tinnitus prevalence in New Zealand. N Z Med J 2015; 128 (1423): 24-34
    PubMedGoogle Scholar
  • 19 Günay O, Borlu A, Horoz D. Tinnitus Prevalence Among the Primary Care Patients in Kayseri, Turkiye. :8.
    Google Scholar
  • 20 Kim H-J, Lee H-J, An S-Y. et al. Analysis of the prevalence and associated risk factors of tinnitus in adults. PLoS One 2015; 10 (05) e0127578
    CrossrefPubMedGoogle Scholar
  • 21 Sunwoo W, Lee DY, Lee JY. et al. Characteristics of tinnitus found in anemia patients and analysis of population-based survey. Auris Nasus Larynx 2018; 45 (06) 1152-1158
    CrossrefPubMedGoogle Scholar
  • 22 Church DF, Pryor WA. Free-radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 1985; 64: 111-126
    CrossrefPubMedGoogle Scholar
  • 23 Nondahl DM, Cruickshanks KJ, Huang G-H. et al. Tinnitus and its risk factors in the Beaver Dam offspring study. Int J Audiol 2011; 50 (05) 313-320
    CrossrefPubMedGoogle Scholar
  • 24 Düzenli U, Bozan N, Aslan M, Özkan H, Turan M, Kıroğlu AF. A Retrospective Analysis of Haemotologic Parameters in Patients with Bilateral Tinnitus. East J Med 2018; 23 (04) 264-268
    CrossrefGoogle Scholar
  • 25 Machin SJ, Briggs C. Mean platelet volume: a quick, easy determinant of thrombotic risk?. J Thromb Haemost 2010; 8 (01) 146-147
    CrossrefPubMedGoogle Scholar
  • 26 Yılmaz M, Dağlı MN, Uku Ö. et al. Focusing on a complete blood cell parameter: mean platelet volume levels may be a predictor of coronary slow flow. Vasc Health Risk Manag 2017; 13: 255-261
    CrossrefPubMedGoogle Scholar
  • 27 Kemal O, Müderris T, Başar F, Kutlar G, Gül F. Prognostic value of mean platelet volume on tinnitus. J Laryngol Otol 2016; 130 (02) 162-165
    CrossrefPubMedGoogle Scholar
  • 28 Akil F, Yollu U, Turgut F, Ayral M, Akil E. The Relationship between Tinnitus, Mean Platelet Volume and Neutrophile/ Lymphocyte Ratio-Investigation on the New Focus of the literature. Online J Otolaryngol. Online Journal of Otolaryngology 2017; 7 (01) 16-20
    Google Scholar
  • 29 Bayram A, Yaşar M, Doğan M, Güneri̇ E, Özcan İ. Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and mean platelet volume in patients with tinnitus. ENT Updates. 2016; 5 (03) 103-106
    CrossrefGoogle Scholar
  • 30 Bilal N, Sarıca S, Orhan İ, Samur AA. Tinnitus Olan Hastalarda Hematolojik Parametrelerin Analizi ve Prognostik Önemi. Kocaeli Med J. 2016; 5 (02) 1-7
    Google Scholar
  • 31 Ulusoy B, Bozdemir K, Akyol M, Mişe Hİ, Kutluhan A, Korkmaz MH. Investigation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and mean platelet volume in patients with tinnitus. J Laryngol Otol 2018; 132 (02) 129-132
    CrossrefPubMedGoogle Scholar
  • 32 Yildiz S, Karaca H, Toros SZ. Mean platelet volume and neutrophil to lymphocyte ratio in patients with tinnitus: a case-control study. Rev Bras Otorrinolaringol (Engl Ed) 2020; (Jun): S18 08869420300641
    Google Scholar
  • 33 Ozbay I, Kahraman C, Balikci HH. et al. Neutrophil-to-lymphocyte ratio in patients with severe tinnitus: prospective, controlled clinical study. J Laryngol Otol 2015; 129 (06) 544-547
    CrossrefPubMedGoogle Scholar
  • 34 Yıldız S. Hacmi ve Nötrofil/Lenfosit Oranı Değerlerinin Tinnitus Etyopatogenezindeki Rolünün Araştırılması [Tez]. [İstanbul]: Haydarpaşa Numune Eğitim ve Araştırma Hastanesi; 2017
    Google Scholar
  • 35 Yüksel F, Karataş D. Can Platelet Indices Be New Biomarkers for Subjective Tinnitus?. J Craniofac Surg 2016; 27 (05) e420-e424
    CrossrefPubMedGoogle Scholar
  • 36 Sarıkaya Y, Bayraktar C, Karataş M. et al. Increased mean platelet volume in patients with idiopathic subjective tinnitus. Eur Arch Otorhinolaryngol 2016; 273 (11) 3533-3536
    CrossrefPubMedGoogle Scholar