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DOI: 10.1055/s-0042-1757197
Fecal Microbiota Transplantation Is Effective for Postcolectomy Recurrent Clostridioides difficile Infection
Funding None.
Abstract
Background The outcomes from fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (rCDI) in patients after complete or partial colectomy are not well-defined.
Objectives We sought to report our experience with FMT for rCDI in patients who have undergone colectomy.
Methods Descriptive analyses of FMT outcomes from 2014 to 2020 were performed in patients who previously had undergone complete or partial colectomy.
Results Twenty-nine patients with prior colectomy for inflammatory bowel disease, malignancy, slow-transit constipation refractory to medical therapy, or fulminant CDI underwent FMT for rCDI. Two patients (6.9%) had rCDI within 8 weeks post-FMT. Seven had CDI beyond 8 weeks (median 10 months) with 71% related to antibiotic exposure post-FMT, suggesting a 69% overall success.
Conclusion FMT resolves rCDI in most patients after colectomy with subsequent antibiotic exposure predicting CDI after FMT.
Ethical Statement
The protocol for this study was approved by Mayo Clinic Institutional Review Board. The manuscript has not been submitted or accepted elsewhere. All authors fulfill the criteria for authorship and have approved the revised version of the manuscript. This was a retrospective study and a waiver for informed consent was approved by the IRB.
Author Contributions
The authors confirm contribution to the paper as follows: Study conception and design: J.C., S.K., D.S.P.; data collection: J.C.; analysis and interpretation of results: J.C., S.K., and D.S.P.; draft manuscript preparation: J.C., S.K.; manuscript editing: J.C., M.V.R., R.O., E.V.L. Jr, J.D., D.S.P., S.K. All authors reviewed the results and approved the final version of the manuscript.
Data Availability Statement
The data can be obtained from the corresponding author on a reasonable request.
Publication History
Received: 18 January 2022
Accepted: 05 April 2022
Article published online:
22 September 2023
© 2022. Gastroinstestinal Infection Society of India. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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