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DOI: 10.1055/s-0042-1756703
Sex-Related Differences in Platelet Aggregation: A Literature Review Supplemented with Local Data from a Group of Generally Healthy Individuals
Funding This work was supported by grant NU21J-02-00021 from the Czech Health Research Council, by Charles University (SVV 260 549) and by MH CZ - DRO (UHHK, 00179906). English language was revised by the agency “theBESTtranslation.”![](https://www.thieme-connect.de/media/sth/202305/lookinside/thumbnails/10-1055-s-0042-1756703_03044-1.jpg)
Abstract
The process of platelet aggregation is often influenced by several factors including sex and age. A literature review confirmed the existence of sex-related differences in platelet aggregation. Although 68 out of 78 papers found such differences, there are still some controversies regarding these differences, which can be due to multiple factors (age, trigger, concomitant disease, sample handling, etc.). These outcomes are discussed in line with novel results obtained from a local study, in which blood samples from a total of 53 overall healthy women and men with ages ranging from 20 to 66 years were collected. Aggregation was induced with seven different triggers (ristocetin, thrombin receptor activating peptide 6 [TRAP-6], arachidonic acid [AA], platelet-activating factor 16 [PAF-16], ADP, collagen, or thromboxane A2 analog U-46619) ex vivo. In addition, three FDA-approved antiplatelet drugs (vorapaxar, ticagrelor, or acetylsalicylic acid [ASA]) were also tested. In general, women had higher aggregation responses to some agonists (ADP, TRAP), as well as lower benefit from inhibitors (ASA, vorapaxar). The aggregatory responses to AA and TRAP decreased with age in both sexes, while responses to ADP, U-46619, and PAF were affected by age only in women. In conclusion, more studies are needed to decipher the biological importance of sex-related differences in platelet aggregation in part to enable personalized antiplatelet treatment.
Keywords
platelet aggregation - blood coagulation - antiplatelet drug - correlation of data - sex differencesAuthor Contributions
Study conceptualization and design: A.C., L.J., P.M.; aggregatory experiments: A.C., L.K., J.K., M.H., M.S.P.; bioanalysis: L.J., K.M., L.K.K.; data curation: A.C., P.M., L.J.; patient recruitment: P.S., M.P., F.M., A.Š., V.B.; literature review: A.C., P.M.; manuscript preparation: A.C., P.M.; manuscript revision: A.C., M.H., P.M.; funding acquisition: A.C., L.J., P.M. All authors read and approved the submitted version of the manuscript.
Publication History
Article published online:
07 October 2022
© 2022. Thieme. All rights reserved.
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