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CC BY 4.0 · Indian J Med Paediatr Oncol 2024; 45(04): 279-285
DOI: 10.1055/s-0042-1756477
Review Article

The Role of Bosutinib in Chronic Myeloid Leukemia: An Indian Perspective

Mohan Bajranglal Agarwal
1   Department of Hematology, Lilavati Hospital and Research Center, Mumbai, Maharashtra, India
,
Manthanathu Joseph John 
2   Department of Hemato-Oncology, Christian Medical College, Ludhiana, Punjab, India
,
Punit Jain 
3   Apollo Hospitals, Navi Mumbai, Maharashtra, India
,
Ashok Kumar Vaid
4   Department of Oncology, Medanta, Gurgaon, Haryana, India
,
Ajay Bapna
5   Department of Oncology, Bhagwan Mahaveer Cancer Hospital and Research Center, Jaipur, Rajasthan, India
,
Maheboob Basade
6   Jaslok Hospital, Mumbai, Maharashtra, India
,
Palanki Satya Dattatreya
7   Omega Hospitals, Hyderabad, Telangana, India
,
Anupam Chakrapani
8   BMT Apollo Gleneagles Hospital, Kolkata, West Bengal, India
,
Vijay Ramanan
9   Clinical Hematology, Bone Marrow and Stem Cell Transplant, Yashoda Hematology Clinic, Pune, Maharashtra, India
,
R. Varadarajan
10   Center for Blood Disorder, Chennai, Tamil Nadu, India
,
Murali Subramanian
11   Columbia Asia Hospital, Bangalore, Karnataka, India
,
Chirag Aniruddha Shah
12   Apollo CBCC Cancer Care hospital, Ahmedabad, Gujarat, India
,
Narayanakutty Warrier
13   MVR Cancer Center and Research Institute, Calicut, Kerala, India
,
Subhaprakash Sanyal
14   Fortis Hospital, Mumbai, Maharashtra, India
,
Tyavanagi Shankarmurthy Ashwin
15   Mylan Pharmaceuticals Private Limited (A Viatris Company), Prestige Tech Park, Kadubeesanahalli, Bengaluru, Karnataka, India
,
Nagendra Ramanjinappa 
15   Mylan Pharmaceuticals Private Limited (A Viatris Company), Prestige Tech Park, Kadubeesanahalli, Bengaluru, Karnataka, India
› Author Affiliations Funding Funding for this study was provided by Viatris (Mylan India)
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Abstract

Management of chronic myeloid leukemia (CML) has been transformed by the use of tyrosine kinase inhibitors (TKIs). Presently in India, five TKIs are approved for the management of CML with distinct safety profiles. The selection of TKIs for chronic phase (CP)-CML patients is based on treatment goals, underlying comorbidities, and specific TKI toxicity profiles. Bosutinib is one of five TKIs indicated for the first-line treatment of CP-CML and patients with intolerance or resistance to prior TKI therapy. It possesses a distinct safety profile among other TKIs, with less cardiovascular adverse events (AEs), albeit the liver-related and gastrointestinal AEs have higher occurrence. The safety and efficacy of bosutinib have been examined in clinical trials; however, there is a paucity of data from Asia. A virtual expert panel meeting was convened to gather expert opinion from India on the selection of bosutinib as a treatment choice for patients with CP-CML. This is a white paper document drafted with the help of an expert panel of 14 oncologists and hematooncologists from India on bosutinib use in CP-CML. The experts concurred that bosutinib has proven efficacy for CP-CML in global randomized clinical trials and is well suited for CP-CML patients with existing cardiovascular comorbidities. However, it was not recommended for patients with gastrointestinal, pancreatic, or renal abnormalities. This review aims to put forth expert opinion and guidance document on key considerations for CP-CML clinical decision-making in India.

Keywords

chronic myeloid leukemia - India - bosutinib - tyrosine kinase inhibitors - chronic phase

Authors' Contributions

All authors adhered to the ICMJE authorship criteria. All authors reviewed and revised the manuscript for important intellectual content.




Publication History

Article published online:
28 November 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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