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Homœopathic Links 2022; 35(02): 113-124
DOI: 10.1055/s-0042-1755369
Original Article

Agraphis nutans in Treatment of Chronic Tonsillitis: Randomised, Pragmatic, Equivalence Trial

Sunanda Chakraborty 
1   Department of Materia Medica, National Institute of Homoeopathy, Ministry of AYUSH, Govt. of India, Kolkata, West Bengal, India
,
Usha Ghelani Uchat
1   Department of Materia Medica, National Institute of Homoeopathy, Ministry of AYUSH, Govt. of India, Kolkata, West Bengal, India
,
Priyanka Ghosh
2   Department of Organon of Medicine and Homoeopathic Philosophy, D. N. De Homoeopathic Medical College and Hospital, Kolkata, Govt. of West Bengal, West Bengal, India
,
Navin Kumar Singh
3   Department of Repertory, The Calcutta Homoeopathic Medical College and Hospital, affiliated to The West Bengal University of Health Sciences, Govt. of West Bengal, Kolkata, West Bengal, India
,
Munmun Koley 
4   Department of Health & Family Welfare, East Bishnupur State Homoeopathic Dispensary, Chandi Daulatabad Block Primary Health Centre, West Bengal, Govt. of West Bengal, India
,
Subhranil Saha 
5   Department of Repertory, D. N. De Homoeopathic Medical College and Hospital, Govt. of West Bengal; affiliated to The West Bengal University of Health Sciences, Kolkata, West Bengal, India
› Institutsangaben Funding This study did not receive any specific grant from any funding agencies in the public, commercial or not-for-profit sectors.
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Abstract

Background Agraphis nutans (AN) is a potential homeopathic medicine in the treatment of chronic tonsillitis, but has remained under-researched. This trial attempts to compare the effects of AN with individualised homeopathic medicines (IHMs) in the treatment of chronic tonsillitis in adults.

Methods An open, randomised, pragmatic, equivalence trial was conducted to compare the effects of AN with IHMs. Sixty adults suffering from chronic tonsillitis were randomised to receive either AN (n = 30) or IHMs (n = 30). Three visual analogue scales (VASs) in the sore throat pain model (STPM) – sore throat pain intensity scale (STPIS), difficulty swallowing scale (DSS) and swollen throat scale (swoTS)—were used as the primary outcome while tonsil and adenoid health status instrument (TAHSI) and Glasgow benefit inventory (GBI) as the secondary outcomes; and they were measured after 6 and 12 weeks. Intention-to-treat sample was analysed to detect non-inferiority of AN against IHMs and group differences using two-ways (split-half) repeated measure analysis of variance and unpaired t-tests.

Results Reductions in all three STPM-VASs, TAHSI and GBI total and subscale scores were significant in the IHMs group (all p < 0.001, except TAHSI halitosis and nocturnal breathing subscale scores), but not in the AN group. Still, except GBI, non-inferiority was exhibited by AN against IHMs in rest of the outcomes after 6 and 12 weeks (all p < 0.001). Hepar sulphuris calcareum (n = 11; 36.7%) and Mercurius solubilis (n = 3; 10%) were the most frequently prescribed remedies in the IHMs group.

Conclusion AN performed non-inferior to IHMs in treatment of chronic tonsillitis in adults; however, it may result from suppression of symptoms. Rigorous and larger trials are warranted.

Trial Registration: CTRI/2018/10/016233; UTN: U1111–1221–8221.

Keywords

Agraphis nutans - chronic tonsillitis - homeopathy - quality of life - randomised controlled trial

Ethical Declaration

The study protocol was in accordance with the latest revision of the Helsinki Declaration on Human Experimentation.14


Disclosure Statement

The trial was conducted as part of the postgraduate thesis of the corresponding author.


Supplementary Material



Publikationsverlauf

Artikel online veröffentlicht:
16. August 2022

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  • References

  • 1 Accessed July 20, 2022 from. https://www.icd10data.com/ICD10CM/Codes/J00-J99/J30-J39/J35-/J35.01
    PubMed
  • 2 Dhingra PL, Dhingra S, Dhingra D. Diseases of Ear, Nose and Throat & Head and Neck Surgery. 6th edition. Netherlands: Elsevier; 2014
    Suche in Google Scholar
  • 3 Hembrom R, Roychaudhuri BK, Saha AK. et al. Evaluation of the validity of high serum antistreptolysin o titre only, as an indication for tonsillectomy. Indian J Otolaryngol Head Neck Surg 2014; 66 (03) 232-236
    CrossrefPubMedSuche in Google Scholar
  • 4 Abu Bakar M, McKimm J, Haque SZ, Majumder MAA, Haque M. Chronic tonsillitis and biofilms: a brief overview of treatment modalities. J Inflamm Res 2018; 11: 329-337
    CrossrefPubMedSuche in Google Scholar
  • 5 Billings KR, Maddalozzo J. Complementary and integrative treatments: adenotonsillar disease. Otolaryngol Clin North Am 2013; 46 (03) 329-334
    CrossrefPubMedSuche in Google Scholar
  • 6 Furuta SE, Weckx LLM, Figueiredo CR. Randomized, double-blind trial on the efficacy of homeopathic treatment in children with recurrent tonsillitis. Revista de Homeopatia 2017; 80: 136-141
    PubMedSuche in Google Scholar
  • 7 Robertson A, Suryanarayanan R, Banerjee A. Homeopathic Arnica montana for post-tonsillectomy analgesia: a randomised placebo control trial. Homeopathy 2007; 96 (01) 17-21
    Thieme ConnectPubMedSuche in Google Scholar
  • 8 Patel RP. The Art of Case Taking and Practical Repertorization in Homoeopathy. 6th edition. New Delhi: Indian Books and Periodicals Publishers; 1998
    Suche in Google Scholar
  • 9 Hering C. The Homoeopathic Domestic Physician, 11th American edition. Philadelphia: Boericke & Tafel; 1904
    Suche in Google Scholar
  • 10 Boericke W. Boericke's New Manual of Homoeopathic Materia Medica with Repertory. 2nd revise and re-augmented ed. 28th impression. New Delhi: B. Jain Publishers Pvt. Ltd.; 2011
    Suche in Google Scholar
  • 11 Clarke JH. A Dictionary of Practical Materia Medica. Vol. I. 35th impression. New Delhi: B. Jain Publishers Pvt. Ltd.; 2018
    Suche in Google Scholar
  • 12 Rabe RF. Two remedies: Agraphis nutans and Euonymus atropurpurea. The Homoeopathic Recorder. 1948; LXIII (1), LXIV (7)
    PubMed
  • 13 Carleton S. Therapeutic encroachments upon the field of surgery. Proceedings of the 36th annual meeting of the International Hahnemannian Association: 1915
    PubMed
  • 14 World Medical Association.. World Medical Association Declaration of Helsinki. Ethical principles for medical research involving human subjects. Bull World Health Organ 2001; 79 (04) 373-374
    PubMedSuche in Google Scholar
  • 15 Schachtel BP, Fillingim JM, Beiter DJ, Lane AC, Schwartz LA. Subjective and objective features of sore throat. Arch Intern Med 1984; 144 (03) 497-500
    CrossrefPubMedSuche in Google Scholar
  • 16 Schachtel B, Aspley S, Shephard A, Shea T, Smith G, Schachtel E. Utility of the sore throat pain model in a multiple-dose assessment of the acute analgesic flurbiprofen: a randomized controlled study. Trials 2014; 15: 263
    CrossrefPubMedSuche in Google Scholar
  • 17 Stewart MG, Friedman EM, Sulek M. et al. Validation of an outcomes instrument for tonsil and adenoid disease. Arch Otolaryngol Head Neck Surg 2001; 127 (01) 29-35
    CrossrefPubMedSuche in Google Scholar
  • 18 Naiboğlu B, Külekçi S, Kalaycık C, Sheidaei S, Toros SZ, Egeli E. Improvement in quality of life by adenotonsillectomy in children with adenotonsillar disease. Clin Otolaryngol 2010; 35 (05) 383-389
    CrossrefPubMedSuche in Google Scholar
  • 19 Robinson K, Gatehouse S, Browning GG. Measuring patient benefit from otorhinolaryngological surgery and therapy. Ann Otol Rhinol Laryngol 1996; 105 (06) 415-422
    CrossrefPubMedSuche in Google Scholar
  • 20 Schwentner I, Höfer S, Schmutzhard J, Deibl M, Sprinzl GM. Impact of tonsillectomy on quality of life in adults with chronic tonsillitis. Swiss Med Wkly 2007; 137 (31-32): 454-461
    PubMedSuche in Google Scholar
  • 21 Senska G, Ellermann S, Ernst S, Lax H, Dost P. Recurrent tonsillitis in adults: quality of life after tonsillectomy. Dtsch Arztebl Int 2010; 107 (36) 622-628
    PubMedSuche in Google Scholar
  • 22 Piaggio G, Elbourne DR, Pocock SJ, Evans SJ, Altman DG. CONSORT Group. Reporting of noninferiority and equivalence randomized trials: extension of the CONSORT 2010 statement. JAMA 2012; 308 (24) 2594-2604
    Suche in Google Scholar
  • 23 Dean ME, Coulter MK, Fisher P, Jobst K, Walach H. Reporting data on homeopathic treatments (RedHot): a supplement to CONSORT. Homeopathy 2007; 96 (01) 42-45
    Thieme ConnectPubMedSuche in Google Scholar
  • 24 Malapane E, Solomon EM, Pellow J. Efficacy of a homeopathic complex on acute viral tonsillitis. J Altern Complement Med 2014; 20 (11) 868-873
    CrossrefPubMedSuche in Google Scholar
  • 25 Palm J, Kishchuk VV, Ulied À. et al; TocTo Research Group. Effectiveness of an add-on treatment with the homeopathic medication SilAtro-5-90 in recurrent tonsillitis: an international, pragmatic, randomized, controlled clinical trial. Complement Ther Clin Pract 2017; 28: 181-191
    CrossrefPubMedSuche in Google Scholar
  • 26 Ostermann T, Park AL, De Jaegere S. et al. Cost-effectiveness analysis for SilAtro-5-90 adjuvant treatment in the management of recurrent tonsillitis, compared with usual care only. Cost Eff Resour Alloc 2021; 19 (01) 60
    CrossrefPubMedSuche in Google Scholar
  • 27 Hahnemann S. The Chronic Diseases, Their Peculiar Nature and Their Homoeopathic Cure. Vol I. Reprint ed. New Delhi: B. Jain Publishers Pvt. Ltd.; 2005. :56, 57, 67, 72
    Suche in Google Scholar
  • 28 Dey SP. Essentials of Principles and Practice of Homoeopathy. 4th edition. Howrah: Published by Smt. A Bhattacharya; 2005. :124
    Suche in Google Scholar
  • 29 Allen JH. The Chronic Miasm Psora and Pseudo-psora. Reprint edition. New Delhi: B. Jain Publishers Pvt. Ltd.; 1998. :197
    Suche in Google Scholar
  • 30 Saxton J. Miasms as Practical Tools: A Homoeopathic Approach to Chronic Disease. South Asian edition. New Delhi: Elsevier; 2008. :121
    Suche in Google Scholar