CC BY 4.0 · Chinese medicine and natural products 2022; 02(01): e11-e18
DOI: 10.1055/s-0042-1754431
Review Article

Therapy of Suppressing Yang and Astringing Yin for the Treatment of Cancer-Related Insomnia

Ranpei Zhu
1   The First School of Clinical Medicine, Henan University of Chinese Medicine, Zhengzhou, Henan, China
,
Xu Sun
2   Integrative Medicine, Henan Cancer Hospital, Zhengzhou, Henan, China
,
Yuling Zheng
1   The First School of Clinical Medicine, Henan University of Chinese Medicine, Zhengzhou, Henan, China
› Author Affiliations
Funding This work was supported by “Hundred-Thousand-Ten Thousand” Talents Project of Chinese Medicine Inheritance and Innovation (Qihuang Project)—Qihuang Scholars (284 Official Letter of People's Education of Chinese Medicine 2018); Special Scientific Research Project of National Clinical Research Base of Traditional Chinese Medicine (2019JDZX001); Special Scientific Research Project of National Clinical Research Base of Chinese Medicine (2019JDZX028); Key Scientific Research Project of Henan Province Colleges and Universities (20A360005); and Henan Province Science and Technology Research and Social Development Project (202102310497).

Abstract

The pathogenesis of cancer-related insomnia (CRI) mainly includes, first, the flow of cancerous toxin leading to the disorder of visceral qi; second, cancer-related radiotherapy and chemotherapy belonging to “exogenous pathogenic factors” to a certain extent, which can further aggravate visceral disorders. The therapeutic principle of Chinese medicine is to tranquilize the mind on the basis of regulating viscera, suppressing yang, and astringing yin. On this theoretical basis, Professor Zheng Yuling created a representative prescription of Zhenjing Anshen Granules which can achieve the co-regulation of the heart, liver, and kidney, tranquilizing the mind and nourishing the blood. Clinically, the selection of prescriptions and medicines needs to be considered due to factors such as different treatment stages and differences in patients' constitutions.

Credit Autorship Contribution Statement

Ranpei Zhu: Conceptualization visualization and writing - original draft. Xu Sun: Methodology, writing review & editing. Yuling Zheng: Conceptualization, supervision, writing review & editing.




Publication History

Received: 12 September 2021

Accepted: 31 October 2021

Article published online:
07 July 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Yao JL, Tian JH. Adjusting physiological and psychological function to treat cancer-related insomnia. Shaanxi J Tradit Chin Med 2020; 41 (02) 213-216
  • 2 Wang M, Zhang ZM, Song ZY. et al. Professor Zhang Zhiming's clinical experience in differentiating and treating malignant tumor-related insomnia. Clin J Chin Med 2020; 12 (27) 4-6 , 13
  • 3 Deng XQ, Liang H, Lin HY. et al. Clinical investigation on the occurrence and characteristics of insomnia and its effect on quality of life in patients with malignant tumor. World J Sleep Med 2020; 7 (01) 11-13
  • 4 Wang X. Modern Hypnosophy. Beijing: Mil Sci Publ House; 2008: 134-145
  • 5 Robertson ME, McSherry F, Herndon JE, Peters KB. Insomnia and its associations in patients with recurrent glial neoplasms. Springerplus 2016; 5 (01) 823
  • 6 Tang LL, Zhan SQ, Yu EY. et al. Expert advice for diagnosis and treatment of insomnia in adult patients with cancer. Chin Ment Health J 2021; 35 (06) 441-448
  • 7 Zhao HQ, Fu ZS. Clinical experience in the treatment of intractable insomnia from the perspective of viscera. World Latest Med Inform 2016; 16 (39) 133-134
  • 8 Lu Y, Cao F. Analysis of the correlation between sleep quality and the formation of tumor in Chinese medicine. Sichuan Zhongyi 2016; 34 (07) 42-44
  • 9 Yan LY, Yu H, Gu XH. et al. Gu Xiaohong's experience in treating insomnia with heart-kidney coordination. Zhonghua Zhongyiyao Zazhi 2017; 32 (07) 3000-3004
  • 10 Tang DC, Wu QG. Science of Chinese Materia Medica, 3rd ed. Beijing: People's Med Publ House Co. Ltd.; 2016: 163-289
  • 11 Jiang T, Zhang GJ. Consideration on the genesis of 'heat governing spirit'. Zhonghua Zhongyiyao Zazhi 2019; 34 (05) 1855-1858
  • 12 Wei SX, Liu Q, Wang P. Insomnia due to either five Zang-organ in treatise on cold damage and miscellaneous diseases and the treatment from the mind. J Tradit Chin Med 2018; 59 (13) 1169-1170
  • 13 Zou TJ, Lin J, Zhang DY. et al. Analysis on the application of the mind-tranquilizing marine Chinese materia medicinals. Guid J Tradit Chin Med Pharm 2019; 25 (19) 116-120
  • 14 Dai CM, Liao XY, Ye ZG. Review on chemical composition, pharmacological activity and application of marine traditional Chinese medicine oyster. Nat Prod Res Dev 2016; 28 (03) 471-474 , 437
  • 15 Tong Y, Du WX, Li Y. et al. Guizhi Gancao Longgu Muli decoction anti-arrhythmia effects. Jilin J Tradit Chin Med 2015; 35 (05) 537-540
  • 16 Liu D, Dai TT, Cha RB. et al. Study on sedative and hypnotic effects of Concha Margaritifera and its different processed products on the content of 5-HT in the brain of mice. Jilin J Tradit Chin Med 2014; 34 (01) 61-63
  • 17 Jin Y. Pharmacological action and clinical application of Concha Margaritifera with hypnotic effects. Zhejiang J Tradit Chin Med 2017; 52 (05) 388-389
  • 18 Li Y, Sun JM, Zhang J. et al. Anti-depressant effect of Margaritifera concha on mice. Jilin J Tradit Chin Med 2014; 34 (04) 388-389 , 392
  • 19 Du CH, Cui XF, Pei XP. et al. Research progress on Ziziphi Spinosae Semen saponins and its biological action on nervous system. Chin Tradit Herbal Drugs 2019; 50 (05) 1258-1268
  • 20 Han P, Ji L, Hu XY. et al. Chemical components, pharmacological action and clinical application of Ziziphi Spinosae Semen. Acta Chin Med Pharm 2021; 49 (02) 110-114
  • 21 Huang QQ, Lin LH. Research progress of sedative Chinese medicine polygala tenuifolia. World J Sleep Med 2021; 8 (01) 183-184
  • 22 Pi T, Liang YQ, Ou WLR. et al. Senegenin protects against lipopolysaccharide-induced neurite toxicity in a nerve cell model. Chin J Com Med 2020; 30 (11) 52-58
  • 23 Li ZZ, Li W, Zhang DS. Pharmacological research on polygala tenuifolia for the treatment of depression. Chin J Pharm Toxicol 2019; 33 (09) 711-712
  • 24 Tao LY, Gao YQ, Wei J. et al. Pharmacological action and clinical application of caulis polygoni multiflori. Lishizhen Med Materia Medica Res 2018; 29 (10) 2486-2488
  • 25 Wu D, Sun CL. Chinese pharmacological research overview of Chinese medicine Junci Medulla. China Pract Med 2015; 10 (14) 288-289
  • 26 Wang YL, Huang JM, Zhang SF. et al. Sedative fraction from Juncus effuses L. J Beijing Univ. Zhong Yi Xue 2006; 29 (03) 181-183
  • 27 Zhu W. Study on Jianpi Yiqi decoction combined with acupoint application in prevention and treatment of gastrointestinal reaction after tumor chemotherapy. Chin Heal Stand Manage 2021; 12 (10) 107-110
  • 28 Zhang YL, Jiao LJ, Xu L. Progress of lung cancer treatment by using traditional Chinese medicine combined with chemotherapy. Zhonghua Zhongyiyao Zazhi 2021; 36 (04) 2222-2224
  • 29 Duan YR, Xiao YH, Li QY. Tumor-related insomnia treated by the methods of warming yang and benefiting qi, relieving depression and tranquilizing mind. Glob Tradit Chin Med 2021; 14 (02) 258-260