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DOI: 10.1055/s-0042-1753488
Outpatient Use of Monoclonal Antibodies Casirivimab and Imdevimab in Pregnancy for Mild-to-Moderate Coronavirus Disease 2019
Funding None.![](https://www.thieme-connect.de/media/ajp/202403/lookinside/thumbnails/10-1055-s-0042-1753488_220985-1.jpg)
Abstract
Objective The aim of this study was to report the use casirivimab/imdevimab therapy in pregnant women with moderate coronavirus disease 2019 (COVID-19).
Study Design We report 12 cases of unvaccinated pregnant patients with mild-to-moderate COVID-19 treated with casirivimab/imdevimab.
Results Twelve unvaccinated pregnant patients with mild-to-moderate COVID-19 received casirivimab/imdevimab at the dose of 1200/1200 mg by intravenous infusion over 60 minutes. All women were managed outpatient. None experienced severe adverse drug reaction and none progressed to severe disease.
Conclusion Casirivimab/imdevimab should be considered for outpatient treatment of unvaccinated pregnant women with mild-to-moderate COVID-19 to decrease the risk of severe disease.
Key Points
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Casirivimab/imdevimab is not well studied in pregnant women.
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Casirivimab/imdevimab in pregnant women with mild-to-moderate COVID-19 decreases the risk of severe disease.
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Casirivimab/imdevimab in pregnant women with mild-to-moderate COVID-19 is well tolerated.
Publication History
Received: 21 January 2022
Accepted: 03 June 2022
Article published online:
18 April 2023
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