Synthesis 2024; 56(04): 549-552
DOI: 10.1055/s-0042-1751470
special topic
Synthetic Development of Key Intermediates and Active Pharmaceutical Ingredients (APIs)

An Alternative Formal Synthesis of (S)-(+)-Vigabatrin

Sudhir P. Chaskar
a   API R & D Centre, Emcure Pharmaceuticals Ltd., ITBT Park, Phase-II, MIDC, Hinjewadi, Pune-411057, Maharashtra, India
,
Ramchandra Honparkhe
a   API R & D Centre, Emcure Pharmaceuticals Ltd., ITBT Park, Phase-II, MIDC, Hinjewadi, Pune-411057, Maharashtra, India
,
Arvind K. Aghao
b   Belbhim College, Department of Chemistry, Beed, Maharashtra, India
,
a   API R & D Centre, Emcure Pharmaceuticals Ltd., ITBT Park, Phase-II, MIDC, Hinjewadi, Pune-411057, Maharashtra, India
,
Chinmoy Pramanik
a   API R & D Centre, Emcure Pharmaceuticals Ltd., ITBT Park, Phase-II, MIDC, Hinjewadi, Pune-411057, Maharashtra, India
› Author Affiliations


Abstract

An improved synthesis of chirally pure advanced pyrrolidone intermediate of the (S)-(+)-vigabatrin, an antiseizure active pharmaceutical ingredient (API) is reported. The synthesis is developed using commercially available, cheaper amino acid (R)-methionine. Meldrum’s acid served as a two-carbon homologation unit to access the pyrrolidone intermediate in a short synthetic sequence. The sequence to pyrrolidone intermediate is scalable and eludes the use of organometallic pyrophoric reagents on a large scale.

Supporting Information



Publication History

Received: 17 March 2023

Accepted after revision: 07 June 2023

Article published online:
03 July 2023

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