CC BY 4.0 · SynOpen 2023; 07(02): 209-242
DOI: 10.1055/s-0042-1751453
review
Virtual Collection Click Chemistry and Drug Discovery

Synthesis of Bioactive Macrocycles Involving Ring-Closing Metathesis Strategy

Nasrin Jahan
,
Inul Ansary  ∗
We sincerely thank the Department of Science and Technology and Biotechnology (Government of West Bengal) for providing financial assistance till the year 2022. We also acknowledge the Department of Science and Technology, Ministry of Science and Technology (New Delhi) for providing the HRMS instrument (Thermo Scientific) under FIST programme. N. Jahan is grateful to Government of West Bengal for her research fellowship, Swami Vivekananda Merit Cum Means Fellowship.
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Abstract

This review reports the synthesis of various bioactive macrocycles, involving ring-closing metathesis as a key step, developed since ca. 2000. These macrocycles exhibited biological activities such as antiviral, antifungal, antibacterial, and anticancer activities, and more. Thus, their syntheses and utilization are essential for both synthetic organic and medicinal chemists.

Key words

macrocycles - ring-closing metathesis - antiviral - antifungal - anticancer - antibiotic


Publication History

Received: 31 January 2023

Accepted after revision: 03 April 2023

Article published online:
23 May 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)

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