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DOI: 10.1055/s-0042-1751402
Recent Advances in Quinone Methide Chemistry for Protein-Proximity Capturing
Startup fund from HUST and Open Fund supported by the State Key Laboratory of Natural and Biomimetic Drugs (K202218).
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Dedicated to Professor Guoqiang Lin on the occasion of his 80th birthday.
Abstract
Here we summarize the most recent findings in the chemical-, photo-, or enzyme-triggered generation of nitrogen and oxygen anions leading to the formation of quinone methide intermediates (QMIs). This short review is divided into two categories: generation of nitrogen and oxygen anions. Based on quinone methide intermediates (QMIs), proximate capture of a wide range of proteins has been widely determined and studied. Generally, the triggers include, photoirradiation using 365/254 nm UV light, small molecules (ROS/TBAF/s-tetrazine), metal catalysis (iridium catalysis), and enzymes (NQO1/β-galactosidase). New directions including far-red light, heat, force, microwave, and more practical approaches are explored and illustrated.
1 Introduction
2 Generation of the Nitrogen Anion
3 Generation of the Oxygen Anion
4 Conclusion
Key words
quinone methide chemistry - reactive oxygen species - boronic acid - photoirradiation - NAD(P)H quinone dehydrogenase 1 - β-galactosidase - protein-protein interactionsPublication History
Received: 30 October 2022
Accepted after revision: 01 December 2022
Article published online:
03 January 2023
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