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DOI: 10.1055/s-0042-1751393
Simplified Synthesis of an Air-Stable Copper-Complexed Josiphos Ligand via Ugi’s Amine: Complete Preparation and Analysis from Ferrocene
The project described was supported by the National Institute of General Medical Sciences (R35 GM118055).
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This paper is dedicated to Professor David A. Evans (1941–2022), a true teacher and scholar.
Abstract
Ligands containing ferrocene backbones often feature both planar chirality and asymmetric centers, making them attractive options for asymmetric catalysis. Ugi’s amine is a ubiquitous ferrocene-based chiral building block that can be functionalized to form a variety of tunable Josiphos ligands; however, few sources lay out the route from start to finish. Starting from ferrocene, we compile a synthetic route to an air- and moisture-stable copper(I)-Josiphos complex via enantiopure Ugi’s amine, providing a potential one-stop shop for the synthesis of a wide range of Josiphos ligands.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0042-1751393.
- Supporting Information
Publikationsverlauf
Eingereicht: 27. Oktober 2022
Angenommen nach Revision: 21. November 2022
Artikel online veröffentlicht:
15. Dezember 2022
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