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DOI: 10.1055/s-0042-1749686
Rationale and Initiative of the Impella in Cardiac Surgery (ImCarS) Register Platform
Funding The ImCarS registry is funded by Abiomed.![](https://www.thieme-connect.de/media/thoracic/202206/lookinside/thumbnails/10-1055-s-0042-1749686_226560o-1.jpg)
Abstract
Objectives Cardiac support systems are being used increasingly more due to the growing prevalence of heart failure and cardiogenic shock. Reducing cardiac afterload, intracardiac pressure, and flow support are important factors. Extracorporeal membrane oxygenation (ECMO) and intracardiac microaxial pump systems (Impella) as non-permanent MCS (mechanical circulatory support) are being used increasingly.
Methods We reviewed the recent literature and developed an international European registry for non-permanent MCS.
Results Life-threatening conditions that are observed preoperatively often include reduced left ventricular function, systemic hypoperfusion, myocardial infarction, acute and chronic heart failure, myocarditis, and valve vitia. Postoperative complications that are commonly observed include severe systemic inflammatory response, ischemia-reperfusion injury, trauma-related disorders, which ultimately may lead to low cardiac output (CO) syndrome and organ dysfunctions, which necessitates a prolonged ICU stay. Choosing the appropriate device for support is critical. The management strategies and complications differ by system. The “heart-team” approach is inevitably needed.
However despite previous efforts to elucidate these topics, it remains largely unclear which patients benefit from certain systems, when is the right time to initiate (MCS), which support system is appropriate, what is the optimal level and type of support, which therapeutic additive and supportive strategies should be considered and ultimately, what are the future prospects and therapeutic developments.
Conclusion The European cardiac surgical register ImCarS has been established as an IIT with the overall aim to evaluate data received from the daily clinical practice in cardiac surgery. Interested colleagues are cordially invited to join the register.
Clinical registration number: DRKS00024560.
Positive Ethics Vote: AZ 246/20 Faculty of Medicine, Justus-Liebig-University-Gießen.
Authors' Contributions
B.N., S.R., A.B., and C.S. have contributed to conception, data collection, writing, and proofreading of the manuscript., M.W. has contributed toward conception and proofreading, D.S. contributed to writing and proofreading the manuscript. M.B., E.P., M.O., P.A., B.S., D.S., A.M.B., J.D.S., and P.M. have contributed to proofreading. All authors are investigators of the ImCarS registry.
In addition to presenting the current data situation, we would like to present the ImCarS Register in Europe and invite the readers in Europe to cooperate. This manuscript describes review data. All authors approved the manuscript and this submission. Our local ethics committee has approved our study and register platform.
Publikationsverlauf
Eingereicht: 01. April 2022
Angenommen: 07. April 2022
Artikel online veröffentlicht:
11. Juli 2022
© 2022. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
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