Effective Vitamin D Supplementation in Patients with Tibial Fracture

Abstract

Objective To determine the prevalence of vitamin D deficiency and to evaluate the safety and effectiveness of a new method of cholecalciferol loading in adult patients with a tibial fracture.

Materials and Methods We recruited 56 consecutive patients with ages ranging from 18 to 65 years with tibial fracture who were admitted to our hospital for 1 year. We determined the level of 25-hydroxyvitamin D ([25 (OH)-D]) at admission and after supplementation with a weekly dose of 100,000 IU of cholecalciferol for 3 or 5 weeks in cases of insufficiency ([25 (OH)-D] between 20 ng/mL and29.9 ng/mL) or deficiency ([25 (OH)D] < 20ng/mL) respectively. The prevalence of hypovitaminosis D, the percentage of vitamin D normalization, and the adverse effects were reported.

Results We evaluated 56 patients with tibia fractures; 98.1% presented hypovitaminosis D, and 28 (73,7%) and 10 (26,3%) showed deficit and insufficiency respectively. A total of 92.1% of the patients reached normal vitamin D levels after supplementation. No patient presented adverse effects.

Discussion The prevalence of vitamin D deficiency in our population was higher than the rates previously reported in the literature. The new vitamin D supplementation scheme proposed is safe and more effective than the one previously recommended. This supplementation scheme can be implemented in future randomized studies.

Conclusion The prevalence of hypovitaminosis D in Chilean adult patients with a tibial fracture was high (98.1%). The proposed vitamin D supplementation scheme was safe and effective.

Level of Evidence Therapeutic study. Level 2.

Keywords

bone union - vitamin D deficiency - tibial fracture - vitamin D supplementation

Publication History

Received: 15 February 2022

Accepted: 13 April 2022

Article published online:
11 July 2022

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