Download PDF
CC BY-NC-ND 4.0 · J Neurol Surg Rep 2022; 83(02): e29-e32
DOI: 10.1055/s-0042-1747972
Original Article

Intraosseous Lipoma of the Calvaria in the Early Stage Resembling Normal Fatty Marrow

Shunsuke Nagase 
1   Department of Diagnostic Pathology, Juntendo University Nerima Hospital, Tokyo, Japan
,
Kanako Ogura
1   Department of Diagnostic Pathology, Juntendo University Nerima Hospital, Tokyo, Japan
,
Karin Ashizawa
1   Department of Diagnostic Pathology, Juntendo University Nerima Hospital, Tokyo, Japan
,
Asumi Sakaguchi
1   Department of Diagnostic Pathology, Juntendo University Nerima Hospital, Tokyo, Japan
,
Shiori Hotchi
1   Department of Diagnostic Pathology, Juntendo University Nerima Hospital, Tokyo, Japan
,
Makoto Hishii
2   Department of Neurosurgery, Juntendo University Nerima Hospital, Tokyo, Japan
,
Masaharu Fukunaga
3   Department of Pathology, Shin-Yurigaoka General Hospital, Kanagawa, Japan
,
Toshiharu Matsumoto
1   Department of Diagnostic Pathology, Juntendo University Nerima Hospital, Tokyo, Japan
› Author Affiliations Funding None.
› Further Information
Also available at
   Permissions and Reprints

Abstract

Intraosseous lipoma (IOL) is a benign bone tumor that usually arises from the lower limb and rarely arises from the skull. Radiological diagnosis of a typical case is not problematic due to its characteristic calcification and marginal sclerosis. Here, we report a case of calvarial IOL in the early stage lacking conventional radiopathological features. The patient is a 7-year-old girl who presented with a slow-growing protuberance on the vertex of the head. Computed tomography displayed a low-density mass without calcification that was continuous with the surrounding diploe. The mass was resected piece by piece for diagnostic and cosmetic reasons. Histologically, the specimen consisted of bony trabeculae and intertrabecular adipose tissue, which resembled normal fatty marrow. However, adipose tissue was considered neoplastic since it lacked hematopoietic elements. The final diagnosis of IOL was made by radiopathological correlation. This case suggests that IOL should be included in the differential diagnosis of diploic expansion, even if calcification is absent. The histology of an early-stage IOL resembles normal fatty marrow, but recognizing the absence of hematopoietic elements aids the diagnosis. Also, our literature review indicates that such cases are likely to be encountered in the calvaria than cranial base.

Keywords

early - intraosseous - lipoma - skull - calvaria - diploe


Publication History

Received: 12 February 2021

Accepted: 19 October 2021

Article published online:
17 May 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Chow LT, Lee KC. Intraosseous lipoma. A clinicopathologic study of nine cases. Am J Surg Pathol 1992; 16 (04) 401-410
    CrossrefPubMedGoogle Scholar
  • 2 Unni KK, Inwards CY, Research MFME. Dahlin's Bone Tumors: General Aspects and Data on 10,165 Cases. 6th edition.. Wolters Kluwer Health/Lippincott Williams & Wilkins; Philadelphia, PA: 2009
    Google Scholar
  • 3 Campbell RSD, Grainger AJ, Mangham DC, Beggs I, Teh J, Davies AM. Intraosseous lipoma: report of 35 new cases and a review of the literature. Skeletal Radiol 2003; 32 (04) 209-222
    CrossrefPubMedGoogle Scholar
  • 4 Propeck T, Bullard MA, Lin J, Doi K, Martel W. Radiologic-pathologic correlation of intraosseous lipomas. AJR Am J Roentgenol 2000; 175 (03) 673-678
    CrossrefPubMedGoogle Scholar
  • 5 Abdalla WM, da Motta AC, Lin SY, McCarthy EF, Zinreich SJ. Intraosseous lipoma of the left frontoethmoidal sinuses and nasal cavity. AJNR Am J Neuroradiol 2007; 28 (04) 615-617
    PubMedGoogle Scholar
  • 6 Elsurer C, Hancı D, Cakir A, Dal T. Isolated intraosseous lipoma of the ethmoid sinus. J Craniomaxillofac Surg 2013; 41 (08) 718-720
    CrossrefPubMedGoogle Scholar
  • 7 Eyzaguirre E, Liqiang W, Karla GM, Rajendra K, Alberto A, Gatalica Z. Intraosseous lipoma. A clinical, radiologic, and pathologic study of 5 cases. Ann Diagn Pathol 2007; 11 (05) 320-325
    CrossrefPubMedGoogle Scholar
  • 8 Han Z, Liu Y, Hao X, Li C, Tian Y. Large intraosseous lipoma of the skull: a case report and review of the literature. World Neurosurg 2018; 120: 525-529
    CrossrefPubMedGoogle Scholar
  • 9 Hazarika P, Pujary K, Kundaje HG, Rao PL. Osteolipoma of the skull base. J Laryngol Otol 2001; 115 (02) 136-139
    CrossrefPubMedGoogle Scholar
  • 10 Jamrozik Z, Rosiak G, Kierdaszuk B. et al. Intraosseous lipoma of the sphenoid: a case study. Case Rep Neurol Med 2013; 2013: 519341
    PubMedGoogle Scholar
  • 11 Kaneko Y, Hokao K, Ogasawara N, Nakano S, Masuda T. [A case of intraosseous lipoma in the frontal bone]. No Shinkei Geka 2011; 39 (10) 975-980
    PubMedGoogle Scholar
  • 12 Lanišnik B, Didanovič V. Sphenoclival intraosseous lipoma: case report and literature review. Skull Base 2007; 17 (03) 211-214
    Article in Thieme ConnectPubMedGoogle Scholar
  • 13 MacFarlane MR, Soule SS, Hunt PJ. Intraosseous lipoma of the body of the sphenoid bone. J Clin Neurosci 2005; 12 (01) 105-108
    CrossrefPubMedGoogle Scholar
  • 14 Milgram JW. Intraosseous lipomas. A clinicopathologic study of 66 cases. Clin Orthop Relat Res 1988; (231) 277-302
    PubMedGoogle Scholar
  • 15 Nahles G, Schaeper F, Bier J, Klein M. An intraosseous lipoma in the frontal bone–a case report. Int J Oral Maxillofac Surg 2004; 33 (04) 408-410
    CrossrefPubMedGoogle Scholar
  • 16 Rosenbloom SA, Osborne DR. Lipoma of the frontal bone. AJNR Am J Neuroradiol 1985; 6 (05) 833-834
    PubMedGoogle Scholar
  • 17 Small ML, Green WR, Johnson LC. Lipoma of the frontal bone. Arch Ophthalmol 1979; 97 (01) 129-132
    CrossrefPubMedGoogle Scholar
  • 18 Solari D, Angel VF, Barcelò SR. et al. Intraosseous lipoma of the skull base, involving the sphenoclival region: case report. Clin Neurol Neurosurg 2012; 114 (10) 1368-1370
    CrossrefPubMedGoogle Scholar
  • 19 Srubiski A, Csillag A, Timperley D, Kalish L, Qiu MR, Harvey RJ. Radiological features of the intraosseous lipoma of the sphenoid. Otolaryngol Head Neck Surg 2011; 144 (04) 617-622
    CrossrefPubMedGoogle Scholar
  • 20 Tomabechi M, Sako K, Daita G, Yonemasu Y. Lipoma involving the skull. Case report. J Neurosurg 1992; 76 (02) 312-314
    CrossrefPubMedGoogle Scholar
  • 21 Yasuda Y, Tsukada S, Okada T, Haseda Y. Intraosseous lipoma of the skull: a report of two cases. Ann Plast Surg 1987; 18 (01) 74-80
    CrossrefPubMedGoogle Scholar