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DOI: 10.1055/s-0042-1747972
Intraosseous Lipoma of the Calvaria in the Early Stage Resembling Normal Fatty Marrow
Funding None.![](https://www.thieme-connect.de/media/jnlsr/202202/lookinside/thumbnails/10-1055-s-0042-1747972_210004-1.jpg)
Abstract
Intraosseous lipoma (IOL) is a benign bone tumor that usually arises from the lower limb and rarely arises from the skull. Radiological diagnosis of a typical case is not problematic due to its characteristic calcification and marginal sclerosis. Here, we report a case of calvarial IOL in the early stage lacking conventional radiopathological features. The patient is a 7-year-old girl who presented with a slow-growing protuberance on the vertex of the head. Computed tomography displayed a low-density mass without calcification that was continuous with the surrounding diploe. The mass was resected piece by piece for diagnostic and cosmetic reasons. Histologically, the specimen consisted of bony trabeculae and intertrabecular adipose tissue, which resembled normal fatty marrow. However, adipose tissue was considered neoplastic since it lacked hematopoietic elements. The final diagnosis of IOL was made by radiopathological correlation. This case suggests that IOL should be included in the differential diagnosis of diploic expansion, even if calcification is absent. The histology of an early-stage IOL resembles normal fatty marrow, but recognizing the absence of hematopoietic elements aids the diagnosis. Also, our literature review indicates that such cases are likely to be encountered in the calvaria than cranial base.
Publication History
Received: 12 February 2021
Accepted: 19 October 2021
Article published online:
17 May 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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References
- 1 Chow LT, Lee KC. Intraosseous lipoma. A clinicopathologic study of nine cases. Am J Surg Pathol 1992; 16 (04) 401-410
- 2 Unni KK, Inwards CY, Research MFME. Dahlin's Bone Tumors: General Aspects and Data on 10,165 Cases. 6th edition.. Wolters Kluwer Health/Lippincott Williams & Wilkins; Philadelphia, PA: 2009
- 3 Campbell RSD, Grainger AJ, Mangham DC, Beggs I, Teh J, Davies AM. Intraosseous lipoma: report of 35 new cases and a review of the literature. Skeletal Radiol 2003; 32 (04) 209-222
- 4 Propeck T, Bullard MA, Lin J, Doi K, Martel W. Radiologic-pathologic correlation of intraosseous lipomas. AJR Am J Roentgenol 2000; 175 (03) 673-678
- 5 Abdalla WM, da Motta AC, Lin SY, McCarthy EF, Zinreich SJ. Intraosseous lipoma of the left frontoethmoidal sinuses and nasal cavity. AJNR Am J Neuroradiol 2007; 28 (04) 615-617
- 6 Elsurer C, Hancı D, Cakir A, Dal T. Isolated intraosseous lipoma of the ethmoid sinus. J Craniomaxillofac Surg 2013; 41 (08) 718-720
- 7 Eyzaguirre E, Liqiang W, Karla GM, Rajendra K, Alberto A, Gatalica Z. Intraosseous lipoma. A clinical, radiologic, and pathologic study of 5 cases. Ann Diagn Pathol 2007; 11 (05) 320-325
- 8 Han Z, Liu Y, Hao X, Li C, Tian Y. Large intraosseous lipoma of the skull: a case report and review of the literature. World Neurosurg 2018; 120: 525-529
- 9 Hazarika P, Pujary K, Kundaje HG, Rao PL. Osteolipoma of the skull base. J Laryngol Otol 2001; 115 (02) 136-139
- 10 Jamrozik Z, Rosiak G, Kierdaszuk B. et al. Intraosseous lipoma of the sphenoid: a case study. Case Rep Neurol Med 2013; 2013: 519341
- 11 Kaneko Y, Hokao K, Ogasawara N, Nakano S, Masuda T. [A case of intraosseous lipoma in the frontal bone]. No Shinkei Geka 2011; 39 (10) 975-980
- 12 Lanišnik B, Didanovič V. Sphenoclival intraosseous lipoma: case report and literature review. Skull Base 2007; 17 (03) 211-214
- 13 MacFarlane MR, Soule SS, Hunt PJ. Intraosseous lipoma of the body of the sphenoid bone. J Clin Neurosci 2005; 12 (01) 105-108
- 14 Milgram JW. Intraosseous lipomas. A clinicopathologic study of 66 cases. Clin Orthop Relat Res 1988; (231) 277-302
- 15 Nahles G, Schaeper F, Bier J, Klein M. An intraosseous lipoma in the frontal bone–a case report. Int J Oral Maxillofac Surg 2004; 33 (04) 408-410
- 16 Rosenbloom SA, Osborne DR. Lipoma of the frontal bone. AJNR Am J Neuroradiol 1985; 6 (05) 833-834
- 17 Small ML, Green WR, Johnson LC. Lipoma of the frontal bone. Arch Ophthalmol 1979; 97 (01) 129-132
- 18 Solari D, Angel VF, Barcelò SR. et al. Intraosseous lipoma of the skull base, involving the sphenoclival region: case report. Clin Neurol Neurosurg 2012; 114 (10) 1368-1370
- 19 Srubiski A, Csillag A, Timperley D, Kalish L, Qiu MR, Harvey RJ. Radiological features of the intraosseous lipoma of the sphenoid. Otolaryngol Head Neck Surg 2011; 144 (04) 617-622
- 20 Tomabechi M, Sako K, Daita G, Yonemasu Y. Lipoma involving the skull. Case report. J Neurosurg 1992; 76 (02) 312-314
- 21 Yasuda Y, Tsukada S, Okada T, Haseda Y. Intraosseous lipoma of the skull: a report of two cases. Ann Plast Surg 1987; 18 (01) 74-80