Clin Colon Rectal Surg 2022; 35(02): 106-112
DOI: 10.1055/s-0042-1744356
Review Article

Transanal Local Excision or Endoscopic Dissection for Benign and Large Lesions of the Rectum

Mario Morino
1   Department of Surgical Sciences, University of Torino, Torino, Italy
,
Alberto Arezzo
1   Department of Surgical Sciences, University of Torino, Torino, Italy
› Author Affiliations

Abstract

Since the introduction of transanal endoscopic microsurgery, local excision of “early” rectal lesions has offered the possibility to reduce the invasiveness of treatment for the limited disease. Flexible endoscopy techniques allow today different alternatives consisting of endoscopic mucosal resection or endoscopic submucosal dissection. The first is a straightforward and relatively easy technique, but it prevents a correct pathological staging of the lesion due to fragmentation and the verification of disease-free margins. The second relies on operators' audacity depending on their increasing experience due to the limited progress in technology. What is the preferable technique today is questionable. All the methods have pros and cons. The future certainly will see the use of ideal systems, allowing the possibility of precision surgery for partial- or full-thickness excision, depending on intraoperative findings, and the extension above the rectosigmoid junction. Miniaturized flexible robotic devices may represent the solution for both issues.



Publication History

Article published online:
28 February 2022

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  • References

  • 1 Buess G, Theiss R, Hutterer F. et al. Transanal endoscopic surgery of the rectum - testing a new method in animal experiments [in German]. Leber Magen Darm 1983; 13 (02) 73-77
  • 2 Buess G, Hutterer F, Theiss J, Böbel M, Isselhard W, Pichlmaier H. A system for a transanal endoscopic rectum operation [in German]. Chirurg 1984; 55 (10) 677-680
  • 3 Mentges B, Buess G, Raestrup H, Manncke K, Becker HD. TEM results of the Tuebingen group. Endosc Surg Allied Technol 1994; 2 (05) 247-250
  • 4 Hermanek P, Gall FP. Early (microinvasive) colorectal carcinoma. Pathology, diagnosis, surgical treatment. Int J Colorectal Dis 1986; 1 (02) 79-84
  • 5 Senagore A, Milsom JW, Talbott TM, Muldoon JP, Mazier WP. Intrarectal ultrasonography in the staging and management of rectal tumors. Am Surg 1988; 54 (06) 352-355
  • 6 Marusch F, Ptok H, Sahm M. et al. Endorectal ultrasound in rectal carcinoma–do the literature results really correspond to the realities of routine clinical care?. Endoscopy 2011; 43 (05) 425-431
  • 7 Gao Y, Hu JL, Zhang XX. et al. Accuracy of endoscopic ultrasound in rectal cancer and its use in transanal endoscopic microsurgery. Minim Invasive Ther Allied Technol 2020; 29 (02) 90-97
  • 8 Serra-Aracil X, Gálvez A, Mora-López L. et al. Endorectal ultrasound in the identification of rectal tumors for transanal endoscopic surgery: factors influencing its accuracy. Surg Endosc 2018; 32 (06) 2831-2838
  • 9 Santoro GA, Gizzi G, Pellegrini L, Battistella G, Di Falco G. The value of high-resolution three-dimensional endorectal ultrasonography in the management of submucosal invasive rectal tumors. Dis Colon Rectum 2009; 52 (11) 1837-1843
  • 10 Glynne-Jones R, Wyrwicz L, Tiret E. et al; ESMO Guidelines Committee. Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2017; 28 (Suppl. 04) iv22-iv40 Erratum in: Ann Oncol 2018;29(Suppl 4):iv263. Erratum in: Ann Oncol 2018;29 Suppl 4:iv263
  • 11 Li XT, Sun YS, Tang L, Cao K, Zhang XY. Evaluating local lymph node metastasis with magnetic resonance imaging, endoluminal ultrasound and computed tomography in rectal cancer: a meta-analysis. Colorectal Dis 2015; 17 (06) O129-O135
  • 12 Benson AB, Venook AP, Al-Hawary MM. et al. Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 2018; 16 (07) 874-901
  • 13 Uraoka T, Saito Y, Matsuda T. et al. Endoscopic indications for endoscopic mucosal resection of laterally spreading tumours in the colorectum. Gut 2006; 55 (11) 1592-1597
  • 14 Backes Y, Moss A, Reitsma JB, Siersema PD, Moons LM. Narrow band imaging, magnifying chromoendoscopy, and gross morphological features for the optical diagnosis of T1 colorectal cancer and deep submucosal invasion: a systematic review and meta-analysis. Am J Gastroenterol 2017; 112 (01) 54-64
  • 15 Oka S, Tanaka S, Nakadoi K, Asayama N, Chayama K. Endoscopic features and management of diminutive colorectal submucosal invasive carcinoma. Dig Endosc 2014; 26 (Suppl. 02) 78-83
  • 16 Matsuda T, Fujii T, Saito Y. et al. Efficacy of the invasive/non-invasive pattern by magnifying chromoendoscopy to estimate the depth of invasion of early colorectal neoplasms. Am J Gastroenterol 2008; 103 (11) 2700-2706
  • 17 Kudo SE, Kashida H. Flat and depressed lesions of the colorectum. Clin Gastroenterol Hepatol 2005; 3 (7, suppl 1): S33-S36
  • 18 Participants PW. The Paris endoscopic classification of superficial neoplastic lesions: esophagus, stomach, and colon: November 30 to December 1, 2002. Gastrointest Endosc 2003; 58 (6, Suppl): S3-S43
  • 19 Kudo S, Rubio CA, Teixeira CR, Kashida H, Kogure E. Pit pattern in colorectal neoplasia: endoscopic magnifying view. Endoscopy 2001; 33 (04) 367-373
  • 20 Parks AG. Advances in the surgery of the colon and rectum. Practitioner 1968; 201 (204) 669-675
  • 21 Edmonson JM. History of the instruments for gastrointestinal endoscopy. Gastrointest Endosc 1991; 37 (2, Suppl): S27-S56
  • 22 Allaix ME, Arezzo A, Cassoni P, Famiglietti F, Morino M. Recurrence after transanal endoscopic microsurgery for large rectal adenomas. Surg Endosc 2012; 26 (09) 2594-2600
  • 23 Barendse RM, van den Broek FJ, Dekker E. et al. Systematic review of endoscopic mucosal resection versus transanal endoscopic microsurgery for large rectal adenomas. Endoscopy 2011; 43 (11) 941-949 Erratum in: Endoscopy 2011;43(11):949
  • 24 Barendse RM, Musters GD, de Graaf EJR. et al; TREND Study group. Randomised controlled trial of transanal endoscopic microsurgery versus endoscopic mucosal resection for large rectal adenomas (TREND Study). Gut 2018; 67 (05) 837-846
  • 25 Repici A, Hassan C, De Paula Pessoa D. et al. Efficacy and safety of endoscopic submucosal dissection for colorectal neoplasia: a systematic review. Endoscopy 2012; 44 (02) 137-150
  • 26 Saito Y, Uraoka T, Yamaguchi Y. et al. A prospective, multicenter study of 1111 colorectal endoscopic submucosal dissections (with video). Gastrointest Endosc 2010; 72 (06) 1217-1225
  • 27 Arezzo A, Passera R, Saito Y. et al. Systematic review and meta-analysis of endoscopic submucosal dissection versus transanal endoscopic microsurgery for large noninvasive rectal lesions. Surg Endosc 2014; 28 (02) 427-438
  • 28 Arezzo A, Cortese G, Arolfo S. et al. Transanal endoscopic operation under spinal anaesthesia. Br J Surg 2016; 103 (07) 916-920
  • 29 Rimonda R, Arezzo A, Garrone C, Allaix ME, Giraudo G, Morino M. Electrothermal bipolar vessel sealing system vs. harmonic scalpel in colorectal laparoscopic surgery: a prospective, randomized study. Dis Colon Rectum 2009; 52 (04) 657-661
  • 30 Morino M, Allaix ME, Famiglietti F, Caldart M, Arezzo A. Does peritoneal perforation affect short- and long-term outcomes after transanal endoscopic microsurgery?. Surg Endosc 2013; 27 (01) 181-188
  • 31 Arezzo A, Forcignanò E, Morino M. Robotic endoscopic submucosal dissection and full-thickness excision for laterally spreading tumors of the rectum. Minim Invasive Ther Allied Technol 2020; 1-3 DOI: 10.1080/13645706.2020.1826972.
  • 32 Morino M, Forcignanò E, Arezzo A. Early clinical adoption of a flexible robotic endoscope for local excision of rectal lesions. Br J Surg 2021; 108 (09) e296
  • 33 Morino M, Forcignanò E, Arezzo A. Initial clinical experience with a novel flexible endoscopic robot for transanal surgery. Tech Coloproctol 2022, in press
  • 34 Martin JW, Scaglioni B, Norton JC. et al. Enabling the future of colonoscopy with intelligent and autonomous magnetic manipulation. Nat Mach Intell 2020; 2 (10) 595-606
  • 35 Verra M, Firrincieli A, Chiurazzi M. et al. Robotic-assisted colonoscopy platform with a magnetically-actuated soft-tethered capsule. Cancers (Basel) 2020; 12 (09) 2485
  • 36 Arezzo A, Gagliardi G. Transanal endoscopic microsurgery: is robotics the way to go?. Tech Coloproctol 2021; 25 (11) 1179-1182