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CC BY 4.0 · Glob Med Genet 2022; 09(02): 082-089
DOI: 10.1055/s-0042-1743259
Review Article

Psoriasis: An Immunogenetic Perspective

Ayca Kocaaga
1   Department of Medical Genetics, Eskişehir City Hospital, Eskisehir, Turkey
,
Mustafa Kocaaga
2   Department of Medical Microbiology, Yunus Emre State Hospital, Eskisehir, Turkey
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Abstract

Psoriasis is an erythematous-squamous dermatosis with a polygenic inheritance history. Both environmental and genetic factors play a role in the etiology of the disease. Over the past two decades, numerous linkage analyzes and genome-wide association studies have been conducted to investigate the role of genetic variation in disease pathogenesis and progression. To date, >70 psoriasis susceptibility loci have been identified, including HLA-Cw6, IL12B, IL23R, and LCE3B/3C. Some genetic markers are used in clinical diagnosis, prognosis, treatment, and personalized new drug development that can further explain the pathogenesis of psoriasis. This review summarizes the immunological mechanisms involved in the etiopathogenesis of psoriasis and recent advances in susceptibility genes and highlights new potential targets for therapeutic intervention.

Keywords

autoimmune - genome-wide association study - immunogenetics - psoriasis

Authors' Contributions

A.K. did the conceptualization. M.K. made a figure. Manuscript preparation, writing, and editing were done by A.K. and M.K.




Publication History

Received: 29 November 2021

Accepted: 29 December 2021

Article published online:
25 February 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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