Subjektiver kognitiver Abbau und Demenzentwicklung – Ergebnisse der Leipziger Langzeitstudie in der Altenbevölkerung (LEILA75+)

Zusammenfassung

Anliegen: Prospektive Untersuchung des Demenzrisikos in Abhängigkeit subjektiv erlebten kognitiven Abbaus (subjective cognitive decline/SCD).

Methoden: 595 kognitiv unbeeinträchtigte Personen ab 75 Jahre (LEILA75+-Studie) wurden regelmäßig über 8 Jahre klinisch interviewt und getestet.

Ergebnisse: Unter Berücksichtigung weiterer Einflussvariablen war SCD nicht mit einem signifikant höheren Demenzrisiko assoziiert.

Schlussfolgerung: SCD ist kein eindeutiger Indikator für eine Demenzentwicklung.

Abstract

Objective: Subjective cognitive decline is controversially discussed as early notable sign of future dementia in the literature. Therefore, we aimed to investigate whether SCD predicts dementia in a sample of cognitively unimpaired older individuals (75+).

Methods: 595 cognitively unimpaired individuals who participated in the Leipzig Longitudinal Study of the Aged (LEILA75+) were regularly interviewed and cognitively tested over 8 years. Cox regression analyses were used to determine the association of SCD and development of dementia.

Results: SCD at baseline was not associated with an increased dementia risk when adjusted for covariates. By contrast, subtle deficits on cognitive testing, though within a normal range, indicated higher dementia risk.

Conclusion: SCD is not a clear indicator for the development of dementia. However, individuals who exhibit subtle deficits on cognitive tests, though within the normal range, should be monitored closely as they might be at increased risk for dementia.

Schlüsselwörter

subjektiver kognitiver Abbau - leichte kognitive Beeinträchtigung - Alzheimer-Krankheit - Demenz - Früherkennung

Keywords

subjective cognitive decline - mild cognitive impairment - Alzheimer’s disease - dementia - early detection

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