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DOI: 10.1055/s-0042-117114
New Structurally Diverse Limonoids from the Seeds of Khaya senegalensis
Publikationsverlauf
received 09. Mai 2016
revised 24. August 2016
accepted 06. September 2016
Publikationsdatum:
20. September 2016 (online)
![](https://www.thieme-connect.de/media/plantamedica/20170304/lookinside/thumbnails/10-1055-s-0042-117114_pma0406-1.jpg)
Abstract
Twelve new limonoids (khasenegasins O–Z; 1–12) with three different kinds of skeletons, including eight mexicanolides, two gedunins, and two andirobins, together with four known limonoids (13–16) were isolated from the seeds of Khaya senegalensis. Their structures were determined by extensive spectroscopic analyses (HR-ESI-MS, 1D/2D NMR), and the absolute configurations of 1 and 2 were established by the electronic circular dichroism exciton chirality method. Moreover, a new andirobin-type limonoid (12) showed significant neuroprotective activity against glutamate-induced injury in primary rat cerebellar granule neuronal cells with increased viability of 83.3 ± 6.0 % at 10 µM and 80.3 ± 3.2 % at 1 µM.
Key words
Khaya senegalensis - Meliaceae - limonoids - ECD exciton chirality - neuroprotective activity* These authors contributed equally to this work.
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