Regulation der Beta-Zellen der Langerhans’schen Inseln des Pankreas

Zusammenfassung

Die Deutsche Diabetes Gesellschaft verlieh in diesem Jahr Frau Prof. Dr. Simone Baltrusch den Ferdinand-Bertram-Preis und ehrte sie damit für ihre wegweisenden und innovative Beiträge zur Beta-Zell Funktion. Ihr Arbeitsgebiet ist die Regulation der Beta-Zellen der Langerhans’schen Inseln des Pankreas und die zu einem Typ-2-Diabetes führenden Pathomechanismen; auf diesem Gebiet hat sie wichtige Beiträge (1) zum Glukosesenorenzym Glucokinase, (2) zur Rolle der mitochondrialen Dynamik in der Stimulus-Sekretionskopplung und (3) zur Steuerung der Insulingranulabewegung geleistet. In diesem Artikel fasst Frau Baltrusch ihre wichtigsten Publikationen zusammen.

Abstract

Prof. Dr. Simone Baltrusch received the Ferdinand-Bertram Award from the German Diabetes Assoziation in May 2016 for her outstanding contributions to improve the knowledge of beta cell function. Her research focus is on the regulation of the beta cells in the islets of Langerhans and the pathomechanisms resulting in type 2 diabetes. In this field she participated in the clarification of (1) the glucose sensor enzyme glucokinase, (2) the role of the mitochondrial dynamic in the stimulus secretion coupling and (3) the control of the insulin granule movement. In this article Dr. Baltrusch summarizes the most important findings of her publications.

Schlüsselwörter

Beta-Zellen - Glucokinase - Mitochondrien - Insulingranula

Key words

Beta cells - glucokinase - mitochondria - insulin granule

• Literatur

• 1 Baltrusch S, Tiedge M. Glucokinase regulatory network in pancreatic beta-cells and liver. Diabetes 2006; 55: S55-S64
• 2 Baltrusch S, Lenzen S, Okar DA et al. Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner. The Journal of biological chemistry 2001; 276: 43915-43923
• 3 Massa L, Baltrusch S, Okar DA et al. Interaction of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) with glucokinase activates glucose phosphorylation and glucose metabolism in insulin-producing cells. Diabetes 2004; 53: 1020-1029
• 4 Baltrusch S, Langer S, Massa L et al. Improved metabolic stimulus for glucose-induced insulin secretion through GK and PFK-2/FBPase-2 coexpression in insulin-producing RINm5F cells. Endocrinology 2006; 147: 5768-5776
• 5 Langer S, Okar DA, Schultz J et al. Dimer interface rearrangement of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase rat liver isoenzyme by cAMP-dependent Ser-32 phosphorylation. FEBS letters 2012; 586: 1419-1425
• 6 Baltrusch S, Schmitt H, Brix A et al. Additive activation of glucokinase by the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and the chemical activator LY2121260. Biochemical pharmacology 2012; 83: 1300-1306
• 7 Hofmeister-Brix A, Lenzen S, Baltrusch S. The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic beta-cells. The Biochemical journal 2013; 456: 173-184
• 8 Baltrusch S, Lenzen S. Novel insights into the regulation of the bound and diffusible glucokinase in MIN6 beta-cells. Diabetes 2007; 56: 1305-1315
• 9 Hofmeister-Brix A, Kollmann K, Langer S et al. Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner. The Journal of biological chemistry 2013; 288: 35824-35839
• 10 Schmitt H, Lenzen S, Baltrusch S. Glucokinase mediates coupling of glycolysis to mitochondrial metabolism but not to beta cell damage at high glucose exposure levels. Diabetologia 2011; 54: 1744-1755
• 11 Baltrusch S, Reinhardt F, Tiedge M. Mitochondria as the powerhouse of beta cells. Influence of glucose metabolism and mitochondrial dynamics. Diabetologe 2015; 11: 231-241
• 12 Baltrusch S. Mitochondrial network regulation and its potential interference with inflammatory signals in pancreatic beta cells. Diabetologia 2016; 59: 683-687
• 13 Reinhardt F, Schultz J, Waterstradt R et al. Drp1 guarding of the mitochondrial network is important for glucose-stimulated insulin secretion in pancreatic beta cells. Biochemical and biophysical research communications 2016; 474: 646-651
• 14 Schultz J, Waterstradt R, Kantowski T et al. Precise expression of Fis1 is important for glucose responsiveness of beta cells. The Journal of endocrinology 2016; 230: 81-91
• 15 Baltrusch S, Lenzen S. Monitoring of glucose-regulated single insulin secretory granule movement by selective photoactivation. Diabetologia 2008; 51: 989-996
• 16 Johne C, Baltrusch S. Involvement of Rab3B in the regulation of beta cell insulin secretion. Diabetologia 2015; 58: S280-S280