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Planta Med 2017; 83(01/02): 164-171
DOI: 10.1055/s-0042-110322
Natural Product Chemistry and Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Iridoid Esters from Tabebuia avellanedae and Their In Vitro Anti-inflammatory Activities

Li Zhang
1   College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa City, Japan
2   Faculty of Pharmaceutical Sciences, Henan University of Chinese Medicine, Zhengzhou City, China
,
Isao Hasegawa
1   College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa City, Japan
,
Tomihisa Ohta
1   College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa City, Japan
› Author Affiliations
Further Information

Publication History

received 28 January 2016
revised 26 May 2016

accepted 06 June 2016

Publication Date:
28 June 2016 (online)

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Abstract

A phytochemical investigation of the inner bark of Tabebuia avellanedae Lorentz ex Griseb was carried out by various chromatographic techniques, resulting in the isolation and characterization of eight new iridoid esters, namely Avelladoids A–H (1-8). Their chemical structures were elucidated on the basis of extensive spectroscopic analyses, especially 2D NMR experiments and HRMS data. The anti-inflammatory effects of 1–8 were determined on an LPS-stimulated RAW 264.7 cell line. Among them, compounds 1, 2, and 3 exhibited anti-inflammatory activities by inhibition of NO and PGE2 production in a dose-dependent manner, without altering cell viability.

Key words

Bignoniaceae - Tabebuia avellanedae - iridoid esters - RAW 264.7 cells - anti-inflammatory - NO - PGE2

Supporting Information

 

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