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Planta Med 2016; 82(11/12): 1128-1133
DOI: 10.1055/s-0042-108736
DOI: 10.1055/s-0042-108736
Natural Product Chemistry and Analytical Studies
Original Papers
ent-Eudesmane-Type Sesquiterpenoids from the Chinese Liverwort Chiloscyphus polyanthus var. rivularis [*]
Further Information
Publication History
received 22 February 2016
revised 03 May 2016
accepted 03 May 2016
Publication Date:
23 June 2016 (online)
Abstract
Seven new ent-eudesmane-type sesquiterpenoids (1–7) and six known analogues (8–13) were isolated from the Chinese liverwort Chiloscyphus polyanthus var. rivularis. Their structures were determined from analysis of MS and NMR spectroscopic data and single-crystal X-ray diffraction. A cytotoxic evaluation showed that compound 1 exhibited weak inhibitory activity against the A549 cancer cell line with an IC50 value of 27.7 µM.
Key words
Chiloscyphus polyanthus var. rivularis - Lophocoleaceae - liverwort - ent-eudesmane - single-crystal X-ray diffraction - cytotoxic activity* Dedicated to Professor Dr. Dr. h. c. mult. Kurt Hostettmann recognition of his outstanding contribution to natural product research.
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