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DOI: 10.1055/s-0042-107797
A Ring-D-Seco-Tetranortriterpenoid from Seeds of Carapa procera Active against Breast Cancer Cell Lines
Publikationsverlauf
received 21. Dezember 2015
revised 18. April 2016
accepted 18. April 2016
Publikationsdatum:
25. Mai 2016 (online)
![](https://www.thieme-connect.de/media/plantamedica/20161112/lookinside/thumbnails/10-1055-s-0042-107797_pmz1263-1.jpg)
Abstract
The seeds of Carapa procera are exploited extensively in West African ethnopharmacy for the treatment of several pathologies, including inflammation. They also are effective as insect antifeedants and as a mosquito repellent. With the aim of identifying bioactive principles, an ethyl acetate extract of the defatted seeds was made and fractionated. Two principle compounds were isolated. One of these, 5,6-dehydro-7-deacetoxy-7-oxogedunin (1), while known from another genus of the Meliaceae, is newly identified from the genus Carapa and its X-ray structure is described for the first time. In addition, 1 displayed strong anti-clonogenic activity at 10 µM. The other compound, mexicanolide (2), is known from this species and showed neither cytotoxicity nor anti-clonogenicity. These differences in efficacy are discussed in relation to known structure-activity relationships of limonoids.
Key words
Carapa procera - Meliaceae - phytochemistry - tetranortriterpenoid - limonoid - breast cancer - cell death - clonogenicity-
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