Download PDF
Pädiatrie up2date 2016; 11(03): 283-300
DOI: 10.1055/s-0042-107095
Varia
© Georg Thieme Verlag KG Stuttgart · New York

Pubertätsstörungen

Annette Richter-Unruh
Further Information

Publication History

Publication Date:
29 August 2016 (online)

Also available at
   
Podcasts
 Permissions and Reprints All articles of this category

See also:

„DSD“ – Besonderheiten der GeschlechtsentwicklungPädiatrie up2date 2016; 11(01): 35-49
DOI: 10.1055/s-0041-107271

Fazit

Das Auftreten sekundärer Geschlechtsmerkmale vor dem 8. Geburtstag bei Mädchen und vor dem 9. Geburtstag bei Jungen bedarf immer einer diagnostischen Abklärung. Eine weiterführende Diagnostik bei ausbleibender Pubertätsentwicklung ist ab einem Alter von etwa 13,5 Jahren bei Mädchen und 14,5 Jahren bei Jungen notwendig. Jedem Stehenbleiben der Pubertätsentwicklung von mehr als 1,5 Jahren muss nachgegangen werden. Eine verzögerte Pubertätsentwicklung geht häufig auch mit einer Wachstumsstörung einher. Die häufigste Ursache für eine verspätete Pubertätsentwicklung ist die konstitutionelle Entwicklungsverzögerung. Perzentilen-abweichendes Wachstum bedarf einer Abklärung.

 

  • Literatur

  • 1 Delemarre-van de Waal HA. Application of gonadotropin releasing hormone in hypogonadotropic hypogonadism – diagnostic and therapeutic aspects. Eur J Endocrinol 2004; 151: 89-94
    CrossrefGoogle Scholar
  • 2 Tsutsumi R, Webster NJG. GnRH pulsatility, the pituitary response and reproductive dysfunction. Endocr J 2009; 56: 729-737
    CrossrefGoogle Scholar
  • 3 Waldhauser F, Weissenbacher G, Frisch H et al. Pulsatile secretion of gonadotropins in early infancy. Eur J Pediatr 1981; 137: 71-74
    CrossrefGoogle Scholar
  • 4 Goede J, Hack WW, Sijstermans K et al. Normative values for testicular volume measured by ultrasonography in a normal population from infancy to adolescence. Horm Res Paediatr 2011; 76: 56-64
    Google Scholar
  • 5 Kuijper EA, van Kooten J, Verbeke JI et al. Ultrasonographically measured testicular volumes in 0- to 6-year-old boys. Hum Reprod 2008; 23: 792-796
    CrossrefGoogle Scholar
  • 6 Lin CC, Huang WJ, Chen KK. Measurement of testicular volume in smaller testes: how accurate is the conventional orchidometer?. J Androl 2009; 30: 685-689
    CrossrefGoogle Scholar
  • 7 Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child 1969; 44: 291-303
    CrossrefPubMedGoogle Scholar
  • 8 Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970; 45: 13-23
    CrossrefGoogle Scholar
  • 9 Grumbach MM, Styne DM. Puberty, ontogeny, neuroendocrinology, physiology and disorders. In: Larsen PR, Kronenberg HM, Melmed S, et al. Williams Textbook of Endocrinology. 10th. ed. Philadelphia: Saunders; 2002
    Google Scholar
  • 10 Kaplan SL, Grumbach MM. Pathogenesis of sexual precocity. In: Grumbach MM, , ed. Control of Onset of Puberty. Baltimore: Lippincott Williams and Wilkins; 1990
    Google Scholar
  • 11 Partsch CJ, Hummelink R, Sippell WG. Reference ranges of lutropin and follitropin in the luliberin test in prepubertal and pubertal children using a monoclonal immunoradiometric assay. J Clin Chem Clin Biochem 1990; 28: 49-52
    Google Scholar
  • 12 Lumbroso S, Paris F, Sultan C. European Collaborative Study. Activating Gsalpha mutations: analysis of 113 patients with signs of McCune-Albright syndrome – a European Collaborative Study. J Clin Endocrinol Metab 2004; 89: 2107-2113
    CrossrefGoogle Scholar
  • 13 Richter-Unruh A, Jorch N, Wessels HAT et al. Venous sampling can be crucial in identifying the testicular origin of idiopathic male luteinising hormone-independent sexual precocity. Eur J Pediatr 2002; 161: 668-671
    CrossrefGoogle Scholar
  • 14 Mogensen SS, Aksglaede L, Mouritsen A et al. Pathological and incidental findings on brain MRI in a single-center study of 229 consecutive girls with early or precocious puberty. PLoS One 2012; 7: e29829
    CrossrefGoogle Scholar
  • 15 Heger S, Müller M, Ranke M et al. Long-term GnRH agonist treatment for female central precocious puberty does not impair reproductive function. Mol Cell Endocrinol 2006; 254 – 255: 217-220
    Google Scholar
  • 16 Pasquino AM, Pucarelli I, Accardo F et al. Long-term observation of 87 girls with idiopathic central precocious puberty treated with gonadotropin-releasing hormone analogs: impact on adult height, body mass index, bone mineral content, and reproductive function. J Clin Endocrinol Metab 2008; 93: 190-195
    CrossrefGoogle Scholar
  • 17 Lescheck EW, Curtler GB. Familial male precocious puberty. In: Bardin CW. Current Therapy in Endocrinology and Metabolism. 6th. ed. St. Louis: Mosby; 1997
    Google Scholar
  • 18 Ghai K, Cara JF, Rosenfield RL. Gonadotropin releasing hormone agonist (nafarelin) test to differentiate gonadotropin deficiency from constitutionally delayed puberty in teen-age boys – a clinical research center study. J Clin Endocrinol Metab 1995; 80: 2980-2986
    Google Scholar
  • 19 Jensen TK, Andersson AM, Hjollund NH et al. Inhibin B as a serum marker of spermatogenesis: correlation to differences in sperm concentration and follicle-stimulating hormone levels. A study of 349 Danish men. J Clin Endocrinol Metab 1997; 82: 4059-4063
    CrossrefGoogle Scholar
  • 20 Andersson AM, Toppari J, Haavisto AM et al. Longitudinal reproductive hormone profiles in infants: peak of inhibin B levels in infant boys exceeds levels in adult men. J Clin Endocrinol Metab 1998; 83: 675-681
    CrossrefGoogle Scholar
  • 21 Hero M, Tommiska J, Vaaralahti K et al. Circulating antimüllerian hormone levels in boys decline during early puberty and correlate with inhibin B. Fertil Steril 2012; 97: 1242-1247
    CrossrefGoogle Scholar
  • 22 Costa-Barbosa FA, Balasubramanian R, Keefe KW et al. Prioritizing genetic testing in patients with Kallmann syndrome using clinical phenotypes. J Clin Endocrinol Metab 2013; 98: E943-953
    CrossrefPubMedGoogle Scholar
  • 23 Stolecke H. Sexualsteroide bei Ullrich-Turner-Syndrom und Panhypopituitarismus. Workshop, 14th International Symposium on Growth and Growth Disorders. Budapest: October 1992
    Google Scholar