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DOI: 10.1055/s-0042-101570
Neue Erkenntnisse zur Hyponatriämie
News on hyponatremiaPublikationsverlauf
Publikationsdatum:
07. März 2016 (online)
![](https://www.thieme-connect.de/media/dmw/201607/lookinside/thumbnails/0457_10-1055-s-0042-101570-1.jpg)
Zusammenfassung
Die Hyponatriämie ist die häufigste Elektrolytstörung mit oft verheerend verlaufenden Komplikationen. Sowohl die Hyponatriämie selbst als auch ihre inadäquate Behandlung kann zu ausgeprägten Morbiditäten führen und erhöht das Mortalitätsrisiko betroffener Patienten. Der vorliegende Artikel stellt neue veröffentlichte Erkenntnisse auf diesem Gebiet vor und beleuchtet sie vor dem Hintergrund der Europäischen Praxisleitlinie.
Abstract
Hyponatremia is the most common electrolyte disorder in clinical practice with often severe and devastating complications. Hyponatremia itself as well as its inappropriate management is associated with pronounced morbidity and increased mortality risk. This manuscript presents some relevant novel findings in this field and discusses them in the context of the recently elaborated first European Guideline of hyponatremia.
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Literatur
- 1 Laureno R, Karp BI. Myelinolysis after correction of hyponatremia. Ann Intern Med 1997; 126: 57-62
- 2 Renneboog B, Musch W, Vandemerge X et al. Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits. Am J Med 2006; 119 (71) e1-8
- 3 Cumming K, Hoyle GE, Hutchinson JD, Soiza RL. Prevalence, incidence and etiology of hyponatremia in elderly patients with fragility fractures. PLoS One 2014; 9: e88272
- 4 Usala RL, Fernandez SJ, Mete M et al. Hyponatremia Is Associated With Increased Osteoporosis and Bone Fractures in a Large US Health System Population. J Clin Endocrinol Metab 2015; 100: 3021-3031
- 5 Kruse C, Eiken P, Verbalis J, Vestergaard P. The effect of chronic mild hyponatremia on bone mineral loss evaluated by retrospective national Danish patient data. Bone 2015; 84: 9-14
- 6 Tinning CG, Cochrane LA, Singer BR. Analysis of hyponatraemia associated post-operative mortality in 3897 hip fracture patients. Injury 2015; 46: 1328-1332
- 7 Wannamethee SG, Shaper AG, Lennon L et al. Mild hyponatremia, hypernatremia and incident cardiovascular disease and mortality in older men. Nutr Metab Cardiovasc Dis 2016; 26: 12-19
- 8 Corona G, Giuliani C, Parenti G et al. Moderate hyponatremia is associated with increased risk of mortality: evidence from a meta-analysis. PLoS One 2013; 8: e80451
- 9 Greenberg A, Verbalis JG, Amin AN et al. Current treatment practice and outcomes. Report of the hyponatremia registry. Kidney Int 2015; 88: 167-177
- 10 Spasovski G, Vanholder R, Allolio B et al. Clinical practice guideline on diagnosis and treatment of hyponatraemia. Eur J Endocrinol 2014; 170: G1-47
- 11 Verbalis JG, Goldsmith SR, Greenberg A et al. Diagnosis, evaluation, and treatment of hyponatremia. Am J Med 2013; 126 (10 Suppl 1) S1-42
- 12 Fenske W, Allolio B. The syndrome of inappropriate secretion of antidiuretic hormone: diagnostic and therapeutic advances. Horm Metab Res 2010; 42: 691-702
- 13 Fenske W, Störk S, Koschker AC et al. Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics. J Clin Endocrinol Metab 2008; 93: 2991-2997
- 14 Fenske W, Maier SK, Blechschmidt A et al. Utility and limitations of the traditional diagnostic approach to hyponatremia: a diagnostic study. Am J Med 2010; 123: 652-657
- 15 Fenske WK, Christ-Crain M, Hörning A et al. A copeptin-based classification of the osmoregulatory defects in the syndrome of inappropriate antidiuresis. J Am Soc Nephrol 2014; 25: 2376-2383
- 16 Verbalis JG, Grossman A, Höybye C, Runkle I. Review and analysis of differing regulatory indications and expert panel guidelines for the treatment of hyponatremia. Curr Med Res Opin 2014; 30: 1201-1207
- 17 Rozen-Zvi B, Yahav D, Gheorghiade M et al., Vasopressin receptor antagonists for the treatment of hyponatremia: systematic review and meta-analysis. Am J Kidney Dis 2010; 56: 325-337
- 18 Jaber BL, Almarzougi L, Borgi L et al. Short-term efficacy and safety of vasopressin receptor antagonists for treatment of hyponatremia. Am J Med 2011; 124 (977) e1-9
- 19 Fenske W. Klinische Leitlinie zur Diagnose und Behandlung von Hyponatriämie 2014: Sind die neuen Leitlinien hilfreich?. 17. Intensivkurs für Klinische Endokrinologie, 2014;