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CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2023; 27(03): e393-e399
DOI: 10.1055/s-0041-1742241
Original Research

The Role of Metabolic Syndrome Components in Sensorineural Hearing Loss in Adolescents: A Case-Control Study

Mir Mohammad Jalali 
1   Department of Otolaryngology, Otorhinolaryngology Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
,
Setila Dalili 
2   Department of Pediatric Endocrinology & Metabolism, Pediatrics Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
,
Shahin Koohmanaee 
2   Department of Pediatric Endocrinology & Metabolism, Pediatrics Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
,
Samira Rad 
2   Department of Pediatric Endocrinology & Metabolism, Pediatrics Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
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Abstract

Introduction Metabolic syndrome (MetS) and its associated components were reported as a possible cause of inner ear dysfunction. However, research about the influence of cardiovascular risk factors on hearing thresholds are conducted mainly in adult patients.

Objective The aim of the present study was to investigate auditory function in adolescents with MetS compared with healthy controls.

Methods One hundred adolescents with metabolic syndrome and 200 sex- and age-matched controls were recruited from a university pediatric endocrine clinic from May 2018 to July 2020. Hearing loss was defined as hearing level ≥ 15 dB at speech frequency (SFHL) or high frequency (HFHL) in one or both ears. A multivariable conditional logistic regression analysis examined the correlation between MetS components and several important demographic characteristics, and hearing loss.

Results A total of 165 (55.0%) boys and 135 (45.0%) girls participated in this study. The rates of SFHL and HFHL in adolescents with MetS were 32.0% and 51.0%, respectively. Those values for controls were 5.0% and 15.5%, respectively. The regression analysis showed high triglycerides as a significant predictor for SFHL (odds ratio 10.87; 95% confidence interval: 1.98, 59.74). Neither predictor of interest was significant for HFHL.

Conclusion Hypertriglyceridemia may be an important factor in the pathogenesis of SFHL. However, the strength of the association was not significant with a wide confidence interval. Also, we were unable to find an association between predictors and HFHL with the current sample size. Larger and prospective studies are recommended.

Keywords

sensorineural hearing loss - metabolic syndrome - triglycerides - adolescent


Publication History

Received: 30 March 2021

Accepted: 04 October 2021

Article published online:
04 August 2023

© 2023. Fundação Otorrinolaringologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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