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DOI: 10.1055/s-0041-1740513
Role of Near-Infrared Spectroscopy in Monitoring the Clinical Course of Asphyxiated Neonates Treated with Hypothermia
Funding None.![](https://www.thieme-connect.de/media/ajp/202404/lookinside/thumbnails/10-1055-s-0041-1740513_210423-1.jpg)
Abstract
Objective Hypoxic-ischemic encephalopathy (HIE) affects millions of newborns annually, especially in low-resource settings. Real-time monitoring of hypoxic-ischemic brain damage is urgently needed for assessment of severity and management of neonates with birth asphyxia. Aim of the work is monitoring of near-infrared spectroscopy (NIRS)-measured cerebral regional oxygen saturation (cRSO2) and cerebral fractional tissue oxygen extraction (FTOE) in neonates after birth asphyxia in relation to their clinical course.
Study Design Forty asphyxiated-term and near-term neonates with mild to severe HIE admitted at neonatal intensive care unit of Alexandria University Maternity Hospital from March to October 2019, received therapeutic hypothermia (TH) and had continuous NIRS monitoring of cRSO2 for 72 hours. Infants were categorized into HIE with seizing and nonseizing groups, and abnormal and normal magnetic resonance imaging (MRI) groups.
Results Clinical seizures (CS) occurred in 15 (37.5%) of HIE neonates and 13.3% of them died (n = 2). In the current study, significantly higher cRSO2 and lower FTOE values were found in the seizing infants as compared with nonseizing group (p < 0.001). NIRS-measured day 2-cRSO2 and day 1-FTOE were associated with CS in newborns with HIE and day 1-cRSO2 and FTOE were associated with abnormal MRI at 1 month of age. cRSO2 values were found to correlate positively with initial Thompson score especially in days 1 and 2. Further, neonates with CS were more likely to have MRI abnormalities at follow-up.
Conclusion NIRS measures may highlight differences between asphyxiated neonates who develop CS or later MRI abnormalities and those who do not.
Key Points
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Day 1 FTOE is the early and sensitive predictor for both clinical seizures and abnormal MRI.
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Cerebral oxygenation metrics help in selecting patients in urgent need of an early MRI scan.
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Cerebral oxygenation metrics can be used hand in hand with clinical assessment using Thompson score at admission to select patient candidate for therapeutic hypothermia.
Keywords
hypoxic-ischemia - therapeutic hypothermia - clinical seizures - near-infrared spectroscopy - cRSO2 - FTOENote
Place of work: El-Shatbi Hospital, Pediatric Building, Faculty of Medicine, Sotir street, El Shatbi Medical Campus, Alexandria University, Alexandria Governorate, Egypt.
Ethical Approval
The study protocol has been approved by the Research Ethics Committee of Alexandria Faculty of Medicine: approval no. 0106082 in 8–19–2019 (date of approval). IRB no. is 00012098 and FWA no. is 00018699. Written informed consent was obtained from parents or authorized legal representatives of all newborns who participated in the study for publication of anonymous patients' data.
Publikationsverlauf
Eingereicht: 01. Juni 2021
Angenommen: 01. November 2021
Artikel online veröffentlicht:
29. Dezember 2021
© 2021. Thieme. All rights reserved.
Thieme Medical Publishers, Inc.
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