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Synthesis 2022; 54(10): 2464-2472
DOI: 10.1055/s-0041-1737337
DOI: 10.1055/s-0041-1737337
paper
Nickel-Catalyzed Regioselective Thiolation of Anilides with Thiols
We gratefully acknowledge the financial support of the University of Tehran and the Iran National Science Foundation (INSF, no. 99002277).
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Abstract
An efficient method for direct thiolation of anilides with thiols using NiCl2·6H2O as the catalyst is developed. Using this method, the desired products were successfully synthesized in moderate to good yields. Initial mechanistic studies suggest that this reaction proceeds through a radical pathway.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0041-1737337.
- Supporting Information
Publication History
Received: 04 August 2021
Accepted after revision: 06 December 2021
Article published online:
16 February 2022
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For reviews on C–S bond coupling, see: