Planta Med 2021; 87(15): 1287
DOI: 10.1055/s-0041-1736903
Abstracts
8. Poster Contributions
8.8 Medicinal plants and natural product research on Traditional Medicines

Liposomal formulations of Alkanna tinctoria root extracts for dermal applications

Antigoni E. Koletti
1   School of Chemical Engineering, Aristotle University of Thessaloniki, (AUTh) Thessaloniki
2   Natural Products Research Center of Excellence (NatPro-AUTh), Center for interdisciplinary Research and Innovation (CIRI-AUTh), Thessaloniki
,
Konstantinos N. Kontogiannopoulos
1   School of Chemical Engineering, Aristotle University of Thessaloniki, (AUTh) Thessaloniki
2   Natural Products Research Center of Excellence (NatPro-AUTh), Center for interdisciplinary Research and Innovation (CIRI-AUTh), Thessaloniki
,
Konstantinos Gardikis
3   APIVITA SA, Industrial Park, Markopoulo, Athens
,
Sophia Letsiou
3   APIVITA SA, Industrial Park, Markopoulo, Athens
,
Vassilios P. Papageorgiou
4   IATRON HELLAS IKE, Fragini 9, Thessaloniki
,
Andreana N. Assimopoulou
1   School of Chemical Engineering, Aristotle University of Thessaloniki, (AUTh) Thessaloniki
2   Natural Products Research Center of Excellence (NatPro-AUTh), Center for interdisciplinary Research and Innovation (CIRI-AUTh), Thessaloniki
› InstitutsangabenAEA, KNK and ANA acknowledge support of this work by the project “Upgrading the plant capital” (MIS5002803) implemented under the Action “Reinforcement of the Research and Innovation Infrastructure”, funded by the Operational Programme "Competitiveness, Entrepreneurship and Innovation" (NSRF2014-2020) and co-financed by Greece and the European Union (European Regional Development Fund).
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Alkannins and Shikonins (A/S) are secondary metabolites with a well-established spectrum of biological and pharmacological activities, such as strong wound healing, regenerative, anti-inflammatory, antimicrobial and antioxidant. Their incorporation in liposomes can lead to higher therapeutic efficacy and also minimize side effects. The aim of this work was to encapsulate standardized oily extracts from the roots of Alkanna tinctoria in liposomes for dermal applications. Liposomes were prepared by using Pro-LipoTM Neo (Lucas Mayer Cosmetics), a mixture of already organized phospholipids (pro-liposomes), which can be ordered to liposomes only with water addition. Experimental design (FCC) was employed to evaluate the effect of several parameters (drug/lipid ratio, water phase/lipid phase ratio and A/S concentration in the oily extract) on the mean particle size and encapsulation efficiency (EE) aiming to optimize the liposomal formulation. 32 samples were prepared, fully characterized and evaluated. The optimum formulation showed a mean particle size of 106 nm, z-potential value of -48.1 mV and EE% up to 72%. The in vitro release profiles were satisfactory, and the formulations were stable for a 2 months period.



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Artikel online veröffentlicht:
13. Dezember 2021

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