Decreased Cerebral Oxygenation in Premature Infants with Progressive Posthemorrhagic Ventricular Dilatation May Help with Timing of Intervention

Angelina June; Timothy Heck; Tushar A. Shah; Turaj Vazifedan; William Thomas Bass

doi:10.1055/s-0041-1736533

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 2023; 40(13): 1446-1453
DOI: 10.1055/s-0041-1736533

Original Article

Decreased Cerebral Oxygenation in Premature Infants with Progressive Posthemorrhagic Ventricular Dilatation May Help with Timing of Intervention

Angelina June

¹Department of Pediatrics, Eastern Virginia Medical School, Children's Hospital of King's Daughters, Norfolk, Virginia

,

Timothy Heck

¹Department of Pediatrics, Eastern Virginia Medical School, Children's Hospital of King's Daughters, Norfolk, Virginia

,

Tushar A. Shah

²Division of Neonatal–Perinatal Medicine, Department of Pediatrics, Eastern Virginia Medical School, Children's Hospital of King's Daughters, Norfolk, Virginia

,

Turaj Vazifedan

³Division of Biostatistics, Department of Pediatrics, Eastern Virginia Medical School, Children's Hospital of King's Daughters, Norfolk, Virginia

,

William Thomas Bass

²Division of Neonatal–Perinatal Medicine, Department of Pediatrics, Eastern Virginia Medical School, Children's Hospital of King's Daughters, Norfolk, Virginia

› Institutsangaben

Abstract

Objective The objective of this study was to determine the degree of progressive posthemorrhagic ventricular dilatation (PHVD) that is associated with a significant decrease in regional cerebral oxygen saturation (rScO₂) in premature infants at risk for periventricular–intraventricular hemorrhage (PIVH).

Study Design Cranial ultrasound (US) and near-infrared spectroscopy (NIRS) measurements of rScO₂ were performed on inborn infants with birth weights less than 1,250 g on admission and at 1, 4, and 8 weeks of age. Infants with severe PIVH were studied weekly. A 1-hour average of rScO₂ was compared with the frontal–occipital horn ratio (FOHR) measured the same day. Generalized linear models were used to analyze the relationship between FOHR and rScO₂, by severity of PIVH, and adjusted for gestational age. Cut-off points of 0.55 for FOHR and 45% for rScO₂ were used to calculate odds ratios (OR) and 95% confidence intervals (CI).

Results The study cohort included 63 infants with normal US, 15 with grade-1 or -2 PIVH (mild group), and 21 with grade-3 or -4 PIVH (severe group). Increases in FOHR in the severe group were associated with decreases in rScO₂ at 1 week (p = 0.036), 4 weeks (p = 0.013), and 8 weeks of life (p = 0.001) compared with the normal and mild groups. Infants with FOHR greater than 0.55 were 92% more likely to have rScO₂ less than 45% when compared with infants with FOHR less than 0.55 (OR = 0.08, 95% CI: [0.04, 0.13], p < 0.001).

Conclusion Progressive PHVD (FOHR > 0.55) is a strong predictor of compromised cerebral oxygenation. A combination of rScO₂ and FOHR measurements may aid in identifying infants with PHVD that would benefit from early intervention.

Key Points

Earlier intervention in PHVD may improve outcomes.
PHVD is diagnosed with US measurements of ventricular size.
FOHR > 0.55 is associated with decreased cerebral perfusion.

Keywords

premature infants - periventricular–intraventricular hemorrhage - posthemorrhagic ventricular dilatation - hydrocephalus - cerebral oxygenation - cerebrospinal fluid diversion procedures - ventricular shunting

Volltext

Referenzen

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