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CC BY-NC-ND 4.0 · J Lab Physicians 2022; 14(01): 084-086
DOI: 10.1055/s-0041-1736481
Case Report

Lymphoepithelioma-Like Carcinoma of Urinary Bladder with Diagnostic Dilemma: Case Report of a Rare Variant of Urothelial Carcinoma

Swati Saini
1   Department of Pathology, Government Medical College, Patiala, Punjab, India
,
Monika Garg
1   Department of Pathology, Government Medical College, Patiala, Punjab, India
,
Shaina Goyal
1   Department of Pathology, Government Medical College, Patiala, Punjab, India
,
Anita Chaudhary
1   Department of Pathology, Government Medical College, Patiala, Punjab, India
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Abstract

Lymphoepithelioma-like carcinoma of the urinary bladder is a rare variant of urothelial carcinoma that was first described by Zukerberg in 1991 and confirmed as a type of urothelial carcinoma by the WHO classification of the urinary system tumors. A 63-year-old man presented with the chief complaint of gross hematuria for 2 months. Sections from transurethral resection of the bladder revealed urothelial carcinoma. A radical cystoprostatectomy was performed and a final histopathological examination revealed high-grade muscle-invasive urothelial carcinoma, lymphoepithelial variant. The patient has been receiving adjuvant chemotherapy with no recurrence reported to date. This is the third case reported in India to date to the best of our knowledge. Owing to its rare presentation, no definite treatment guidelines have been established for this entity. Various studies from the English literature suggest a conservative approach.

Keywords

bladder - carcinoma - lymphoepithelioma - urothelial


Publication History

Article published online:
23 November 2021

© 2021. The Indian Association of Laboratory Physicians. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Singh NG, Mannan AA, Rifaat AA, Kahvic M. Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case. Ann Saudi Med 2009; 29 (06) 478-481
    CrossrefPubMedGoogle Scholar
  • 2 Zukerberg LR, Harris NL, Young RH. Carcinomas of the urinary bladder simulating malignant lymphoma. A report of five cases. Am J Surg Pathol 1991; 15 (06) 569-576
    CrossrefPubMedGoogle Scholar
  • 3 Amin MB, Ro JY, Lee KM. et al. Lymphoepithelioma-like carcinoma of the urinary bladder. Am J Surg Pathol 1994; 18 (05) 466-473
    CrossrefPubMedGoogle Scholar
  • 4 Tamas EF, Nielsen ME, Schoenberg MP, Epstein JI. Lymphoepithelioma-like carcinoma of the urinary tract: a clinicopathological study of 30 pure and mixed cases. Mod Pathol 2007; 20 (08) 828-834
    CrossrefPubMedGoogle Scholar
  • 5 Raphael V, Jitani AK, Sailo SL, Vakha M. Lymphoepithelioma-like carcinoma of the urinary bladder: a rare case report. Urol Ann 2015; 7 (04) 516-519
    CrossrefPubMedGoogle Scholar
  • 6 Kushida N, Kushakabe T, Kataoka M, Kumagai S, Aikawa K, Kojima Y. External beam radiotherapy for focal lymphoepithelioma-like carcinoma in the urinary bladder: a case report and literature review. Case Rep Oncol 2015; 8 (01) 15-20
    CrossrefPubMedGoogle Scholar