Download PDF
CC BY-NC-ND 4.0 · European Journal of General Dentistry 2021; 10(02): 91-95
DOI: 10.1055/s-0041-1735765
Original Article

Evaluation of Salivary Interleukin-12, Interleukin-23 Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma

Tahereh Nosratzehi
1   Department of Oral Medicine, Oral and Dental Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
,
Ebrahim Alijani
2   Department of Immunology, Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
,
Neda Hassanpoor
3   Zahedan University of Medical Sciences, Zahedan, Iran
› Author Affiliations
› Further Information
Also available at
   Permissions and Reprints

Abstract

Objectives The present study aimed to evaluate interleukin-12 (IL-12) and IL-23 in the saliva of patients with oral lichen planus (OLP) and oral squamous cell carcinoma (SCC).

Materials and Methods Thirty cases with clinical and histopathological OLP (bilateral lesions, papular and reticular lesions, and Wickham lines) (Group A), 30 with oral SCCs (OSCCs) (Group B), and 30 with no history of oral cancer, other lesions, or lichen planus (Group C) were enrolled at the Department of Oral Medicine School of Dentistry, Zahedan, Iran. The whole unstimulated saliva was collected and the salivary concentration of IL-12 and IL-23 was measured using an enzyme-linked immunosorbent assay in the laboratory.

Statistical Analysis Data were analyzed using Kruskal–Wallis, Mann–Whitney tests, and Pearson's correlation coefficients.

Results In the present study, salivary IL-12 and IL-23 levels were higher in OSCC patients than in OLP and healthy individuals.

Conclusions The results show that although IL-23 and IL-12 cytokines have an important role in the pathogenesis of chronic immunity and inflammatory diseases, further studies are required to assess matrix metalloproteinase links with tumor invasion.

Keywords

interleukin-12 - interleukin-23 - oral lichen planus - oral squamous cell carcinoma

Ethics Approval and Consent to Participate

All participants perceived the nature of the research project and provided written, informed consent to participate in this study. The study was approved by the Ethical Committee of Zahedan University of Medical Sciences (IR. ZAUMS. REC.1395.60).




Publication History

Article published online:
20 September 2021

© 2021. European Journal of General Dentistry. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Nylander E, Ebrahimi M, Wahlin Y-B, Boldrup L, Nylander K. Changes in miRNA expression in sera and correlation to duration of disease in patients with multifocal mucosal lichen planus. J Oral Pathol Med 2012; 41 (01) 86-89
    CrossrefPubMedGoogle Scholar
  • 2 Agha-Hosseini F, Borhan-Mojabi K, Monsef-Esfahani H-R, Mirzaii-Dizgah I, Etemad-Moghadam S, Karagah A. Efficacy of purslane in the treatment of oral lichen planus. Phytother Res 2010; 24 (02) 240-244
    CrossrefPubMedGoogle Scholar
  • 3 Roopashree MR, Gondhalekar RV, Shashikanth MC, George J, Thippeswamy SH, Shukla A. Pathogenesis of oral lichen planus–a review. J Oral Pathol Med 2010; 39 (10) 729-734
    CrossrefPubMedGoogle Scholar
  • 4 Hoffmann RR, Yurgel LS, Campos MM. Evaluation of salivary endothelin-1 levels in oral squamous cell carcinoma and oral leukoplakia. Regul Pept 2011; 166 (1-3) 55-58
    CrossrefPubMedGoogle Scholar
  • 5 Melinceanu L, Sarafoleanu C, Lerescu L, Tucureanu C, Caraş I, Sălăgeanu A. Impact of smoking on the immunological profile of patients with laryngeal carcinoma. J Med Life 2009; 2 (02) 211-218
    PubMedGoogle Scholar
  • 6 Agarwal A, Agrawal U, Verma S, Mohanty NK, Saxena S. Serum Th1 and Th2 cytokine balance in patients of superficial transitional cell carcinoma of bladder pre- and post-intravesical combination immunotherapy. Immunopharmacol Immunotoxicol 2010; 32 (02) 348-356
    CrossrefPubMedGoogle Scholar
  • 7 Lupardus PJ, Garcia KC. The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12. J Mol Biol 2008; 382 (04) 931-941
    CrossrefPubMedGoogle Scholar
  • 8 Langrish CL, Chen Y, Blumenschein WM. et al IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 2005; 201 (02) 233-240
    CrossrefPubMedGoogle Scholar
  • 9 Hillyer P, Larché MJ, Bowman EP. et al Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis. Rheumatology (Oxford) 2009; 48 (12) 1581-1589 doi: DOI: 10.1093/rheumatology/kep293.
    CrossrefPubMedGoogle Scholar
  • 10 Kim HR, Cho ML, Kim KW. et al. Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NF-kappaB- and p38 MAPK-dependent signalling pathways [published correction appears in Rheumatology (Oxford). 2009; 48 (04) 460 Kim H-Y [corrected to Kim, Ho-Youn]]. Rheumatology (Oxford) 2007;46(1):57-64 doi: DOI: 10.1093/rheumatology/kel159.
    CrossrefPubMedGoogle Scholar
  • 11 Paradowska-Gorycka A, Grzybowska-Kowalczyk A, Wojtecka-Lukasik E, Maslinski S. IL-23 in the pathogenesis of rheumatoid arthritis. Scand J Immunol 2010; 71 (03) 134-145
    CrossrefPubMedGoogle Scholar
  • 12 Kathariya R, Pradeep A. Salivary proteomic biomarkers for oral diseases: a review of literature. Arch Oral Sci Res 2010; 1 (01) 43-49
    Google Scholar
  • 13 Kalogerakou F, Albanidou-Farmaki E, Markopoulos AK, Antoniades DZ. Detection of T cells secreting type 1 and type 2 cytokines in the peripheral blood of patients with oral lichen planus. Hippokratia 2008; 12 (04) 230-235
    PubMedGoogle Scholar
  • 14 Chen J, Feng J, Chen X. et al Immunoexpression of interleukin-22 and interleukin-23 in oral and cutaneous lichen planus lesions: a preliminary study. Mediators Inflamm 2013; 2013: 801974 doi: 10.1155/2013/801974
    CrossrefPubMedGoogle Scholar
  • 15 Lu R, Zeng X, Han Q. et al Overexpression and selectively regulatory roles of IL-23/IL-17 axis in the lesions of oral lichen planus. Mediators Inflamm 2014; 2014: 701094 doi: 10.1155/2014/701094
    PubMedGoogle Scholar
  • 16 Ohyama H, Kato-Kogoe N, Kuhara A. et al The involvement of IL-23 and the Th17 pathway in periodontitis. J Dent Res 2009; 88 (07) 633-638
    CrossrefPubMedGoogle Scholar
  • 17 Huang Y, Zhou S, Cai Y. Expression of interleukin-12 and interleukin-27 proteins and immune status in serum of patients with oral lichen planus [article in Chinese]. Hua Xi Kou Qiang Yi Xue Za Zhi 2016; 34 (02) 140-144
    PubMedGoogle Scholar
  • 18 Gorsky M, Epstein JB. Oral lichen planus: malignant transformation and human papilloma virus: a review of potential clinical implications. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 111 (04) 461-464
    CrossrefPubMedGoogle Scholar
  • 19 Hirota M, Ito T, Okudela K. et al Cell proliferation activity and the expression of cell cycle regulatory proteins in oral lichen planus. J Oral Pathol Med 2002; 31 (04) 204-212
    CrossrefPubMedGoogle Scholar