Clin Colon Rectal Surg 2021; 34(06): 366-370
DOI: 10.1055/s-0041-1735266
Review Article

Risk Factors for Anastomotic Leak, Consideration for Proximal Diversion, and Appropriate Use of Drains

Joanne Favuzza
1   Division of Colon and Rectal Surgery, Department of Surgery, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts
› Author Affiliations

Abstract

Anastomotic leaks are a major source of morbidity after colorectal surgery. There is a myriad of risk factors that may contribute to anastomotic leaks. These risk factors can be categorized as modifiable, nonmodifiable, and intraoperative factors. Identification of these risk factors allows for preoperative optimization that may minimize the risk of anastomotic leak. Knowledge of such high-risk features may also affect intraoperative decision-making regarding the creation of an anastomosis, consideration for proximal diversion, or placement of a drain. A thorough understanding of the interplay between risk factors, indications for proximal diversion, and utility of drain placement is imperative for colorectal surgeons.



Publication History

Article published online:
23 November 2021

© 2021. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 
  • References

  • 1 Fielding LP, Stewart-Brown S, Blesovsky L, Kearney G. Anastomotic integrity after operations for large-bowel cancer: a multicentre study. BMJ 1980; 281 (6237): 411-414
  • 2 Lipska MA, Bissett IP, Parry BR, Merrie AEH. Anastomotic leakage after lower gastrointestinal anastomosis: men are at a higher risk. ANZ J Surg 2006; 76 (07) 579-585
  • 3 Golub R, Golub RW, Cantu Jr. R, Stein HD. A multivariate analysis of factors contributing to leakage of intestinal anastomoses. J Am Coll Surg 1997; 184 (04) 364-372
  • 4 Buchs NC, Gervaz P, Secic M, Bucher P, Mugnier-Konrad B, Morel P. Incidence, consequences, and risk factors for anastomotic dehiscence after colorectal surgery: a prospective monocentric study. Int J Colorectal Dis 2008; 23 (03) 265-270
  • 5 Midura EF, Hanseman D, Davis RB. et al. Risk factors and consequences of anastomotic leak after colectomy: a national analysis. Dis Colon Rectum 2015; 58 (03) 333-338
  • 6 Law WI, Chu KW, Ho JWC, Chan CW. Risk factors for anastomotic leakage after low anterior resection with total mesorectal excision. Am J Surg 2000; 179 (02) 92-96
  • 7 McDermott FD, Heeney A, Kelly ME, Steele RJ, Carlson GL, Winter DC. Systematic review of preoperative, intraoperative and postoperative risk factors for colorectal anastomotic leaks. Br J Surg 2015; 102 (05) 462-479
  • 8 Warschkow R, Steffen T, Thierbach J, Bruckner T, Lange J, Tarantino I. Risk factors for anastomotic leakage after rectal cancer resection and reconstruction with colorectostomy. A retrospective study with bootstrap analysis. Ann Surg Oncol 2011; 18 (10) 2772-2782
  • 9 Krysa J, Patel V, Taylor J, Williams AB, Carapeti E, George ML. Outcome of patients on renal replacement therapy after colorectal surgery. Dis Colon Rectum 2008; 51 (06) 961-965
  • 10 Choi HK, Law WL, Ho JWC. Leakage after resection and intraperitoneal anastomosis for colorectal malignancy: analysis of risk factors. Dis Colon Rectum 2006; 49 (11) 1719-1725
  • 11 Sauer R, Becker H, Hohenberger W. et al; German Rectal Cancer Study Group. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004; 351 (17) 1731-1740
  • 12 Qin Q, Ma T, Deng Y. et al. Impact of preoperative radiotherapy on anastomotic leakage and stenosis after rectal cancer resection: post hoc analysis of a randomized controlled trial. Dis Colon Rectum 2016; 59 (10) 934-942
  • 13 Park JS, Huh WJ, Park AY. et al. Risk factors of anastomotic leakage and long-term survival after colorectal surgery. Medicine (Baltimore) 2016; 95 (08) e2890
  • 14 Matthiessen P, Hallböök O, Andersson M, Rutegård J, Sjödahl R. Risk factors for anastomotic leakage after anterior resection of the rectum. Colorectal Dis 2004; 6 (06) 462-469
  • 15 Park JS, Choi GS, Kim SH. et al. Multicenter analysis of risk factors for anastomotic leakage after laparoscopic rectal cancer excision: the Korean laparoscopic colorectal surgery study group. Ann Surg 2013; 257 (04) 665-671
  • 16 Sebag-Montefiore D, Stephens RJ, Steele R. et al. Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet 2009; 373 (9666): 811-820
  • 17 Marijnen CAM, Kapiteijn E, van de Velde CJ. et al; Cooperative Investigators of the Dutch Colorectal Cancer Group. Acute side effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: report of a multicenter randomized trial. J Clin Oncol 2002; 20 (03) 817-825
  • 18 Nisar PJ, Lavery IC, Kiran RP. Influence of neoadjuvant radiotherapy on anastomotic leak after restorative resection for rectal cancer. J Gastrointest Surg 2012; 16 (09) 1750-1757
  • 19 Smith ST, Seski JC, Copeland LJ, Gershenson DM, Edwards CL, Herson J. Surgical management of irradiation-induced small bowel damage. Obstet Gynecol 1985; 65 (04) 563-567
  • 20 Rullier E, Laurent C, Garrelon JL, Michel P, Saric J, Parneix M. Risk factors for anastomotic leakage after resection of rectal cancer. Br J Surg 1998; 85 (03) 355-358
  • 21 Vignali A, Fazio VW, Lavery IC. et al. Factors associated with the occurrence of leaks in stapled rectal anastomoses: a review of 1,014 patients. J Am Coll Surg 1997; 185 (02) 105-113
  • 22 Karanjia ND, Corder AP, Bearn P, Heald RJ. Leakage from stapled low anastomosis after total mesorectal excision for carcinoma of the rectum. Br J Surg 1994; 81 (08) 1224-1226
  • 23 Gu WL, Wu SW. Meta-analysis of defunctioning stoma in low anterior resection with total mesorectal excision for rectal cancer: evidence based on thirteen studies. World J Surg Oncol 2015; 13: 9
  • 24 Fazio VW, O'Riordain MG, Lavery IC. et al. Long-term functional outcome and quality of life after stapled restorative proctocolectomy. Ann Surg 1999; 230 (04) 575
  • 25 Kiely JM, Fazio VW, Remzi FH, Shen B, Kiran RP. Pelvic sepsis after IPAA adversely affects function of the pouch and quality of life. Dis Colon Rectum 2012; 55 (04) 387-392
  • 26 Sørensen LT, Jørgensen T, Kirkeby LT, Skovdal J, Vennits B, Wille-Jørgensen P. Smoking and alcohol abuse are major risk factors for anastomotic leakage in colorectal surgery. Br J Surg 1999; 86 (07) 927-931
  • 27 Sparreboom CL, van Groningen JT, Lingsma HF. et al; Dutch ColoRectal Audit group. Different risk factors for early and late colorectal anastomotic leakage in a nationwide audit. Dis Colon Rectum 2018; 61 (11) 1258-1266
  • 28 Benoist S, Panis Y, Alves A, Valleur P. Impact of obesity on surgical outcomes after colorectal resection. Am J Surg 2000; 179 (04) 275-281
  • 29 Akiyoshi T, Ueno M, Fukunaga Y. et al. Effect of body mass index on short-term outcomes of patients undergoing laparoscopic resection for colorectal cancer: a single institution experience in Japan. Surg Laparosc Endosc Percutaneous Tech 2011; 21 (06) 409-414
  • 30 Senagore AJ, Delaney CP, Madboulay K, Brady KM, Fazio VW. Laparoscopic colectomy in obese and nonobese patients. J Gastrointest Surg 2003; 7 (04) 558-561
  • 31 Canedo J, Pinto RA, Regadas S, Regadas FSP, Rosen L, Wexner SD. Laparoscopic surgery for inflammatory bowel disease: does weight matter?. Surg Endosc 2010; 24 (06) 1274-1279
  • 32 Telem DA, Chin EH, Nguyen SQ, Divino CM. Risk factors for anastomotic leak following colorectal surgery: a case-control study. Arch Surg 2010; 145 (04) 371-376 , discussion 376
  • 33 Mäkelä JT, Kiviniemi H, Laitinen S. Risk factors for anastomotic leakage after left-sided colorectal resection with rectal anastomosis. Dis Colon Rectum 2003; 46 (05) 653-660
  • 34 Koretz RL. Do data support nutrition support? Part I: intravenous nutrition. J Am Diet Assoc 2007; 107 (06) 988-996
  • 35 Konishi T, Watanabe T, Kishimoto J, Nagawa H. Risk factors for anastomotic leakage after surgery for colorectal cancer: results of prospective surveillance. J Am Coll Surg 2006; 202 (03) 439-444
  • 36 Slieker JC, Komen N, Mannaerts GH. et al. Long-term and perioperative corticosteroids in anastomotic leakage: a prospective study of 259 left-sided colorectal anastomoses. Arch Surg 2012; 147 (05) 447-452
  • 37 Yamamoto T, Spinelli A, Suzuki Y. et al. Risk factors for complications after ileocolonic resection for Crohn's disease with a major focus on the impact of preoperative immunosuppressive and biologic therapy: A retrospective international multicentre study. United European Gastroenterol J 2016; 4 (06) 784-793
  • 38 Colombel JF, Loftus Jr. EV, Tremaine WJ. et al. Early postoperative complications are not increased in patients with Crohn's disease treated perioperatively with infliximab or immunosuppressive therapy. Am J Gastroenterol 2004; 99 (05) 878-883
  • 39 Kunitake H, Hodin R, Shellito PC, Sands BE, Korzenik J, Bordeianou L. Perioperative treatment with infliximab in patients with Crohn's disease and ulcerative colitis is not associated with an increased rate of postoperative complications. J Gastrointest Surg 2008; 12 (10) 1730-1736
  • 40 Syed A, Cross RK, Flasar MH. Anti-tumor necrosis factor therapy is associated with infections after abdominal surgery in Crohn's disease patients. Am J Gastroenterol 2013; 108 (04) 583-593
  • 41 Zeeh J, Inglin R, Baumann G. et al. Mycophenolate mofetil impairs healing of left-sided colon anastomoses. Transplantation 2001; 71 (10) 1429-1435
  • 42 Schäffer MR, Fuchs N, Proksch B, Bongartz M, Beiter T, Becker HD. Tacrolimus impairs wound healing: a possible role of decreased nitric oxide synthesis. Transplantation 1998; 65 (06) 813-818
  • 43 Petri JB, Schurk S, Gebauer S, Haustein UF. Cyclosporine A delays wound healing and apoptosis and suppresses activin β-A expression in rats. Eur J Dermatol 1998; 8 (02) 104-113
  • 44 Akkouche A, Sidéris L, Leblanc G, Leclerc YE, Vafiadis P, Dubé P. Complications after colorectal anastomosis in a patient with metastatic rectal cancer treated with systemic chemotherapy and bevacizumab. Can J Surg 2008; 51 (03) E52-E53
  • 45 Davis B, Rivadeneira DE. Complications of colorectal anastomoses: leaks, strictures, and bleeding. Surg Clin North Am 2013; 93 (01) 61-87
  • 46 Qu H, Liu Y, Bi DS. Clinical risk factors for anastomotic leakage after laparoscopic anterior resection for rectal cancer: a systematic review and meta-analysis. Surg Endosc 2015; 29 (12) 3608-3617
  • 47 Leichtle SW, Mouawad NJ, Welch KB, Lampman RM, Cleary RK. Risk factors for anastomotic leakage after colectomy. Dis Colon Rectum 2012; 55 (05) 569-575
  • 48 Bakker IS, Grossmann I, Henneman D, Havenga K, Wiggers T. Risk factors for anastomotic leakage and leak-related mortality after colonic cancer surgery in a nationwide audit. Br J Surg 2014; 101 (04) 424-432 , discussion 432
  • 49 Trencheva K, Morrissey KP, Wells M. et al. Identifying important predictors for anastomotic leak after colon and rectal resection: prospective study on 616 patients. Ann Surg 2013; 257 (01) 108-113
  • 50 Hanna MH, Vinci A, Pigazzi A. Diverting ileostomy in colorectal surgery: when is it necessary?. Langenbecks Arch Surg 2015; 400 (02) 145-152
  • 51 Williams NS, Nasmyth DG, Jones D, Smith AH. De-functioning stomas: a prospective controlled trial comparing loop ileostomy with loop transverse colostomy. Br J Surg 1986; 73 (07) 566-570
  • 52 Geng HZ, Nasier D, Liu B, Gao H, Xu YK. Meta-analysis of elective surgical complications related to defunctioning loop ileostomy compared with loop colostomy after low anterior resection for rectal carcinoma. Ann R Coll Surg Engl 2015; 97 (07) 494-501
  • 53 Montedori A, Cirocchi R, Farinella E, Sciannameo F, Abraha I. Covering ileo- or colostomy in anterior resection for rectal carcinoma. Cochrane Database Syst Rev 2010; (05) CD006878
  • 54 Sciuto A, Merola G, De Palma GD. et al. Predictive factors for anastomotic leakage after laparoscopic colorectal surgery. World J Gastroenterol 2018; 24 (21) 2247-2260
  • 55 Tan WS, Tang CL, Shi L, Eu KW. Meta-analysis of defunctioning stomas in low anterior resection for rectal cancer. Br J Surg 2009; 96 (05) 462-472
  • 56 Matthiessen P, Hallböök O, Rutegård J, Simert G, Sjödahl R. Defunctioning stoma reduces symptomatic anastomotic leakage after low anterior resection of the rectum for cancer: a randomized multicenter trial. Ann Surg 2007; 246 (02) 207-214
  • 57 Wu SW, Ma CC, Yang Y. Role of protective stoma in low anterior resection for rectal cancer: a meta-analysis. World J Gastroenterol 2014; 20 (47) 18031-18037
  • 58 Bhama AR, Batool F, Collins SD, Ferraro J, Cleary RK. Risk factors for postoperative complications following diverting loop ileostomy takedown. J Gastrointest Surg 2017; 21 (12) 2048-2055
  • 59 Bakx R, Busch ORC, Bemelman WA, Veldink GJ, Slors JFM, van Lanschot JJB. Morbidity of temporary loop ileostomies. Dig Surg 2004; 21 (04) 277-281
  • 60 Moss JP. Historical and current perspectives on surgical drainage. Surg Gynecol Obstet 1981; 152 (04) 517-527
  • 61 Emile SH, Abd El-Hamed TM. Routine drainage of colorectal anastomoses: an evidence-based review of the current literature. Gastroenterol Res Pract 2017; 2017: 6253898
  • 62 Tsujinaka S, Konishi F. Drain vs no drain after colorectal surgery. Indian J Surg Oncol 2011; 2 (01) 3-8
  • 63 Rondelli F, Bugiantella W, Vedovati MC. et al. To drain or not to drain extraperitoneal colorectal anastomosis? A systematic review and meta-analysis. Colorectal Dis 2014; 16 (02) O35-O42
  • 64 Jesus EC, Karliczek A, Matos D, Castro AA, Atallah AN. Prophylactic anastomotic drainage for colorectal surgery. Cochrane Database Syst Rev 2004; (04) CD002100
  • 65 Zhang HY, Zhao CL, Xie J. et al. To drain or not to drain in colorectal anastomosis: a meta-analysis. Int J Colorectal Dis 2016; 31 (05) 951-960
  • 66 Denost Q, Rouanet P, Faucheron JL. et al; To drain or not to drain infraperitoneal anastomosis after rectal excision for cancer: the GRECCAR 5 randomized trial. Ann Surg 2017; 265 (03) 474-480
  • 67 Menahem B, Vallois A, Alves A, Lubrano J. Prophylactic pelvic drainage after rectal resection with extraperitoneal anastomosis: is it worthwhile? A meta-analysis of randomized controlled trials. Int J Colorectal Dis 2017; 32 (11) 1531-1538