Synthesis and Characterization of Antifungal Nanocomposite AgSiO2 Polymethyl Methacrylate

Mahmoud Sabouhi; Maryam Amini-Pozveh; Farshad Bajoghli; Hamid reza Dastjerd; Rasoul Mohammadi

doi:10.1055/s-0041-1731831

European Journal of Dentistry, Table of Contents

CC BY 4.0 · Eur J Dent 2022; 16(01): 109-114
DOI: 10.1055/s-0041-1731831

Original Article

Synthesis and Characterization of Antifungal Nanocomposite AgSiO₂ Polymethyl Methacrylate

Mahmoud Sabouhi

¹Department of Prosthodontics, Dental Materials Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

,

Maryam Amini-Pozveh

²Department of Prosthodontics Dentistry, Dental Materials Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

,

Farshad Bajoghli

³Department of Prosthodontics, Dental Implants Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

,

Hamid reza Dastjerd

⁴Institute of Biomaterial of Tehran University, Tehran University of Medical Science, Tehran, Iran

,

Rasoul Mohammadi

⁵Department of Medical Parasitology and Mycology, School of Medicine, Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

› Author Affiliations

Abstract

Objectives Polymethyl methacrylate as the most common material used in denture bases has some problems. The aim of this study was to introduce a new nanocomposite of PMMA to improve flexural strength and antifungal properties.

Materials and Methods In this experimental study, AgSiO₂ nanoparticles were prepared, and their characteristics were confirmed by scanning electron microscope and energy dispersive spectroscopy techniques. Then the nanoparticles in the weight ratio of 0.1, 0.3, 0.5, and 0.7% were incorporated to heat-cured PMMA and the control group included no nanoparticles.

To measure the flexural strength before and after thermocycling three-point bending test was used. Eight samples per group with dimensions of 65 × 10 × 2.5 mm were used. Antifungal activity against Candida albicans (PTCC 5027) was investigated through colony count method. Statistical analysis was done by SPSS at significance level of p-value ≤0.05.

Results The mean flexural strength in groups 0.1, 0.3, and 0.7% was significantly higher than the control. After thermocycling flexural strength of the control group was significantly lower than 0.3 and 0.5% groups. As the concentration of nanoparticles increased the antifungal activity improved (p < 0.05).

Conclusion Addition of nanoparticles AgSiO₂ improved flexural strength and antifungal characteristics of PMMA.

Keywords

antifungal - Candida albicans - colony count - nanocomposite - polymethyl methacrylate - strength

Full Text

References

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