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Thorac Cardiovasc Surg 2022; 70(06): 493-504
DOI: 10.1055/s-0041-1731823
Review Article

Ventricular Assist Device Driveline Infections: A Systematic Review

Kristina Krzelj
1   Department of Cardiac Surgery, University Hospital Center Zagreb, Zagreb, Croatia
,
Mate Petricevic 
2   Division of Health Studies, Department of Cardiac Surgery, University of Split, University Hospital Center Zagreb, Zagreb, Croatia
,
Hrvoje Gasparovic
1   Department of Cardiac Surgery, University Hospital Center Zagreb, Zagreb, Croatia
3   School of Medicine, University of Zagreb, Zagreb, Croatia
,
Bojan Biocina
1   Department of Cardiac Surgery, University Hospital Center Zagreb, Zagreb, Croatia
3   School of Medicine, University of Zagreb, Zagreb, Croatia
,
David McGiffin
4   Department of Cardiothoracic Surgery and Transplantation, Alfred Hospital, Melbourne, Victoria, Australia
5   Monash University, Clayton, Victoria, Australia
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Abstract

Infection is the most common complication in patients undergoing ventricular assist device (VAD) implantation. Driveline exit site (DLES) infection is the most frequent VAD infection and is a significant cause of adverse events in VAD patients, contributing to morbidity, even mortality, and repetitive hospital readmissions. There are many risk factors for driveline infection (DLI) including younger age, smaller constitution of patients, obesity, exposed velour at the DLES, longer duration of device support, lower cardiac index, higher heart failure score, DLES trauma, and comorbidities such as diabetes mellitus, chronic kidney disease, and depression. The incidence of DLI depends also on the device type. Numerous measures to prevent DLI currently exist. Some of them are proven, whereas the others remain controversial. Current recommendations on DLES care and DLI management are predominantly based on expert consensus and clinical experience of the certain centers. However, careful and uniform DLES care including obligatory driveline immobilization, previously prepared sterile dressing change kits, and continuous patient education are probably crucial for prevention of DLI. Diagnosis and treatment of DLI are often challenging because of certain immunological alterations in VAD patients and microbial biofilm formation on the driveline surface areas. Although there are many conservative and surgical methods described in the DLI treatment, the only possible permanent solution for DLI resolution in VAD patients is heart transplantation. This systematic review brings a comprehensive synthesis of recent data on the prevention, diagnostic workup, and conservative and surgical management of DLI in VAD patients.

Keyword

cardiac - circulatory assist devices - infection - heart failure - wound healing - wound infection

Supplementary Material



Publication History

Received: 20 January 2021

Accepted: 26 May 2021

Article published online:
14 September 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Rose EA, Gelijns AC, Moskowitz AJ. et al; Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Study Group. Long-term use of a left ventricular assist device for end-stage heart failure. N Engl J Med 2001; 345 (20) 1435-1443
    CrossrefPubMedSearch in Google Scholar
  • 2 Kirklin JK, Pagani FD, Kormos RL. et al. Eighth annual INTERMACS report: special focus on framing the impact of adverse events. J Heart Lung Transplant 2017; 36 (10) 1080-1086
    CrossrefPubMedSearch in Google Scholar
  • 3 Kormos RL, Cowger J, Pagani FD. et al. The Society of Thoracic Surgeons INTERMACS database annual report: evolving indications, outcomes, and scientific partnerships. J Heart Lung Transplant 2019; 38 (02) 114-126
    CrossrefPubMedSearch in Google Scholar
  • 4 Kusne S, Mooney M, Danziger-Isakov L. et al. An ISHLT consensus document for prevention and management strategies for mechanical circulatory support infection. J Heart Lung Transplant 2017; 36 (10) 1137-1153
    CrossrefPubMedSearch in Google Scholar
  • 5 Kirklin JK, Naftel DC, Pagani FD. et al. Seventh INTERMACS annual report: 15,000 patients and counting. J Heart Lung Transplant 2015; 34 (12) 1495-1504
    CrossrefPubMedSearch in Google Scholar
  • 6 Gosev I, Kiernan MS, Eckman P. et al; Evolving Mechanical Support Research Group (EMERG) Investigators. Long-term survival in patients receiving a continuous-flow left ventricular assist device. Ann Thorac Surg 2018; 105 (03) 696-701
    CrossrefPubMedSearch in Google Scholar
  • 7 Trachtenberg BH, Cordero-Reyes A, Elias B, Loebe M. A review of infections in patients with left ventricular assist devices: prevention, diagnosis and management. Methodist DeBakey Cardiovasc J 2015; 11 (01) 28-32
    CrossrefPubMedSearch in Google Scholar
  • 8 Raju S, MacIver J, Foroutan F, Alba C, Billia F, Rao V. Long-term use of left ventricular assist devices: a report on clinical outcomes. Can J Surg 2017; 60 (04) 236-246
    CrossrefPubMedSearch in Google Scholar
  • 9 de By TM, Mohacsi P, Gummert J. et al; EUROMACS members. The European Registry for Patients with Mechanical Circulatory Support (EUROMACS): first annual report. Eur J Cardiothorac Surg 2015; 47 (05) 770-776 , discussion 776–777
    CrossrefPubMedSearch in Google Scholar
  • 10 Hannan MM, Xie R, Cowger J. et al. Epidemiology of infection in mechanical circulatory support: a global analysis from the ISHLT Mechanically Assisted Circulatory Support Registry. J Heart Lung Transplant 2019; 38 (04) 364-373
    CrossrefPubMedSearch in Google Scholar
  • 11 Shah P, Birk SE, Cooper LB. et al. Stroke and death risk in ventricular assist device patients varies by ISHLT infection category: an INTERMACS analysis. J Heart Lung Transplant 2019; 38 (07) 721-730
    CrossrefPubMedSearch in Google Scholar
  • 12 Belz S, Fisquet S, Ahuja A, Hay K, Lavana J. Incidence of infection and antimicrobial consumption in ventricular assist device (VAD) recipients at the Prince Charles Hospital (TPCH): a retrospective analysis. Heart Lung Circ 2020; 29 (08) 1234-1240
    CrossrefPubMedSearch in Google Scholar
  • 13 Nienaber JJC, Kusne S, Riaz T. et al; Mayo Cardiovascular Infections Study Group. Clinical manifestations and management of left ventricular assist device-associated infections. Clin Infect Dis 2013; 57 (10) 1438-1448
    CrossrefPubMedSearch in Google Scholar
  • 14 Schloglhofer T, Michalovics P, Riebandt J. et al. Left ventricular assist device driveline infections in three contemporary devices. Artif Organs 2020; 0–3
    CrossrefPubMedSearch in Google Scholar
  • 15 Gordon RJ, Weinberg AD, Pagani FD. et al; Ventricular Assist Device Infection Study Group. Prospective, multicenter study of ventricular assist device infections. Circulation 2013; 127 (06) 691-702
    CrossrefPubMedSearch in Google Scholar
  • 16 Rogers JG, Pagani FD, Tatooles AJ. et al. Intrapericardial left ventricular assist device for advanced heart failure. N Engl J Med 2017; 376 (05) 451-460
    CrossrefPubMedSearch in Google Scholar
  • 17 Zinoviev R, Lippincott CK, Keller SC, Gilotra NA. In full flow: left ventricular assist device infections in the modern era. Open Forum Infect Dis 2020; 7 (05) a124
    CrossrefPubMedSearch in Google Scholar
  • 18 Topkara VK, Kondareddy S, Malik F. et al. Infectious complications in patients with left ventricular assist device: etiology and outcomes in the continuous-flow era. Ann Thorac Surg 2010; 90 (04) 1270-1277
    CrossrefPubMedSearch in Google Scholar
  • 19 Sharma V, Deo SV, Stulak JM. et al. Driveline infections in left ventricular assist devices: implications for destination therapy. Ann Thorac Surg 2012; 94 (05) 1381-1386
    CrossrefPubMedSearch in Google Scholar
  • 20 Anselmi A, Galand V, Vincentelli A. et al. Current results of left ventricular assist device therapy in France: the ASSIST-ICD registry. Eur J Cardiothorac Surg 2020; 58 (01) 112-120
    CrossrefPubMedSearch in Google Scholar
  • 21 Liberati A, Altman DG, Tetzlaff J. et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 2009; 62 (10) e1-e34
    Search in Google Scholar
  • 22 Hannan MM, Husain S, Mattner F. et al; International Society for Heart and Lung Transplantation. Working formulation for the standardization of definitions of infections in patients using ventricular assist devices. J Heart Lung Transplant 2011; 30 (04) 375-384
    CrossrefPubMedSearch in Google Scholar
  • 23 Kirklin JK, Naftel DC, Stevenson LW. et al. INTERMACS database for durable devices for circulatory support: first annual report. J Heart Lung Transplant 2008; 27 (10) 1065-1072
    CrossrefPubMedSearch in Google Scholar
  • 24 Monkowski DH, Axelrod P, Fekete T, Hollander T, Furukawa S, Samuel R. Infections associated with ventricular assist devices: epidemiology and effect on prognosis after transplantation. Transpl Infect Dis 2007; 9 (02) 114-120
    CrossrefPubMedSearch in Google Scholar
  • 25 Bomholt T, Moser C, Sander K. et al. Driveline infections in patients supported with a HeartMate II: incidence, aetiology and outcome. Scand Cardiovasc J 2011; 45 (05) 273-278
    CrossrefPubMedSearch in Google Scholar
  • 26 Yoshioka D, Okazaki S, Toda K. et al. Prevalence of cerebral microbleeds in patients with continuous-flow left ventricular assist devices. J Am Heart Assoc 2017; 6 (09) e005955
    CrossrefPubMedSearch in Google Scholar
  • 27 Zierer A, Melby SJ, Voeller RK. et al. Late-onset driveline infections: the Achilles' heel of prolonged left ventricular assist device support. Ann Thorac Surg 2007; 84 (02) 515-520
    CrossrefPubMedSearch in Google Scholar
  • 28 Feldman D, Pamboukian SV, Teuteberg JJ. et al; International Society for Heart and Lung Transplantation. The 2013 International Society for Heart and Lung Transplantation Guidelines for mechanical circulatory support: executive summary. J Heart Lung Transplant 2013; 32 (02) 157-187
    CrossrefPubMedSearch in Google Scholar
  • 29 Baronetto A, Centofanti P, Attisani M. et al. A simple device to secure ventricular assist device driveline and prevent exit-site infection. Interact Cardiovasc Thorac Surg 2014; 18 (04) 415-417
    CrossrefPubMedSearch in Google Scholar
  • 30 Stewart PS, Costerton JW. Antibiotic resistance of bacteria in biofilms. Lancet 2001; 358 (9276): 135-138
    CrossrefPubMedSearch in Google Scholar
  • 31 Flemming HC, Wingender J. The biofilm matrix. Nat Rev Microbiol 2010; 8 (09) 623-633
    CrossrefPubMedSearch in Google Scholar
  • 32 Qu Y, McGiffin D, Kure C. et al. Biofilm formation and migration on ventricular assist device drivelines. J Thorac Cardiovasc Surg 2020; 159 (02) 491-502.e2 , e492
    CrossrefPubMedSearch in Google Scholar
  • 33 Koval CE, Stosor V. AST ID Community of Practice. Ventricular assist device-related infections and solid organ transplantation-guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant 2019; 33 (09) e13552
    CrossrefPubMedSearch in Google Scholar
  • 34 Qu Y, McGiffin D, Hayward C. et al. Characterization of infected, explanted ventricular assist device drivelines: the role of biofilms and microgaps in the driveline tunnel. J Heart Lung Transplant 2020;•:S1053-2498(20)31666-1
    PubMed
  • 35 Toba FA, Akashi H, Arrecubieta C, Lowy FD. Role of biofilm in Staphylococcus aureus and Staphylococcus epidermidis ventricular assist device driveline infections. J Thorac Cardiovasc Surg 2011; 141 (05) 1259-1264
    CrossrefPubMedSearch in Google Scholar
  • 36 Rahal A, Ruch Y, Meyer N. et al. Left ventricular assist device-associated infections: incidence and risk factors. J Thorac Dis 2020; 12 (05) 2654-2662
    CrossrefPubMedSearch in Google Scholar
  • 37 John R, Aaronson KD, Pae WE. et al; HeartWare Bridge to Transplant ADVANCE Trial Investigators. Drive-line infections and sepsis in patients receiving the HVAD system as a left ventricular assist device. J Heart Lung Transplant 2014; 33 (10) 1066-1073
    CrossrefPubMedSearch in Google Scholar
  • 38 Koval CE, Thuita L, Moazami N, Blackstone E. Evolution and impact of drive-line infection in a large cohort of continuous-flow ventricular assist device recipients. J Heart Lung Transplant 2014; 33 (11) 1164-1172
    CrossrefPubMedSearch in Google Scholar
  • 39 Blanco-Guzman MO, Wang X, Vader JM, Olsen MA, Dubberke ER. Epidemiology of left ventricular assist device infections: findings from a large non-registry cohort. Clin Infect Dis 2021; 72 (02) 190-197
    CrossrefPubMedSearch in Google Scholar
  • 40 Nunez Breton JD, Hernandez G, Simkins J, Chaparro SV. Mycobacterium abscessus left ventricle assist device driveline infections: an emerging pathogen?. Transpl Infect Dis 2018; 20 (05) e12957
    CrossrefPubMedSearch in Google Scholar
  • 41 Roest S, Bax HI, Verkaik NJ. et al. Mycobacterium chelonae, an ‘atypical’ cause of an LVAD driveline infection. Int J Infect Dis 2020; 92: 127-129
    CrossrefPubMedSearch in Google Scholar
  • 42 Lehnert AL, Hart A, Branam S, Brouse S, Guglin M. Left ventricular assist device related infections: does the time of onset matter?. J Heart Lung Transplant 2016; 35
    CrossrefPubMedSearch in Google Scholar
  • 43 Goldstein DJ, Naftel D, Holman W. et al. Continuous-flow devices and percutaneous site infections: clinical outcomes. J Heart Lung Transplant 2012; 31 (11) 1151-1157
    CrossrefPubMedSearch in Google Scholar
  • 44 Zafar F, Villa CR, Morales DL. et al. Does small size matter with continuous flow devices?: Analysis of the INTERMACS database of adults with BSA ≤1.5 m2 . JACC Heart Fail 2017; 5 (02) 123-131
    CrossrefPubMedSearch in Google Scholar
  • 45 Raymond AL, Kfoury AG, Bishop CJ. et al. Obesity and left ventricular assist device driveline exit site infection. ASAIO J 2010; 56 (01) 57-60
    CrossrefPubMedSearch in Google Scholar
  • 46 Akay MH, Nathan SS, Radovancevic R. et al. Obesity is associated with driveline infection of left ventricular assist devices. ASAIO J 2019; 65 (07) 678-682
    CrossrefPubMedSearch in Google Scholar
  • 47 McCandless SP, Ledford ID, Mason NO. et al. Comparing velour versus silicone interfaces at the driveline exit site of HeartMate II devices: infection rates, histopathology, and ultrastructural aspects. Cardiovasc Pathol 2015; 24 (02) 71-75
    CrossrefPubMedSearch in Google Scholar
  • 48 Pavlovic NV, Randell T, Madeira T, Hsu S, Zinoviev R, Abshire M. Risk of left ventricular assist device driveline infection: a systematic literature review. Heart Lung 2019; 48 (02) 90-104
    CrossrefPubMedSearch in Google Scholar
  • 49 Dean D, Kallel F, Ewald GA. et al; SSI Registry Investigators. Reduction in driveline infection rates: results from the HeartMate II Multicenter Driveline Silicone Skin Interface (SSI) Registry. J Heart Lung Transplant 2015; 34 (06) 781-789
    CrossrefPubMedSearch in Google Scholar
  • 50 Emani S. Complications of durable left ventricular assist device therapy. Crit Care Clin 2018; 34 (03) 465-477
    CrossrefPubMedSearch in Google Scholar
  • 51 Angud M. Left ventricular assist device driveline infections: the Achilles' heel of destination therapy. AACN Adv Crit Care 2015; 26 (04) 300-305
    CrossrefPubMedSearch in Google Scholar
  • 52 Schaffer JM, Allen JG, Weiss ES. et al. Infectious complications after pulsatile-flow and continuous-flow left ventricular assist device implantation. J Heart Lung Transplant 2011; 30 (02) 164-174
    CrossrefPubMedSearch in Google Scholar
  • 53 Imamura T, Kinugawa K, Nitta D. et al. Readmission due to driveline infection can be predicted by new score by using serum albumin and body mass index during long-term left ventricular assist device support. J Artif Organs 2015; 18 (02) 120-127
    CrossrefPubMedSearch in Google Scholar
  • 54 Martin BJ, Luc JGY, Maruyama M. et al. Driveline site is not a predictor of infection after ventricular assist device implantation. ASAIO J 2018; 64 (05) 616-622
    CrossrefPubMedSearch in Google Scholar
  • 55 Imamura T, Murasawa T, Kawasaki H. Correlation between driveline features and driveline infection in left ventricular assist device selection. J Artif Organs 2017; 20 (01) 34-41
    CrossrefPubMedSearch in Google Scholar
  • 56 Bernhardt AM, Schlöglhofer T, Lauenroth V. et al; Driveline Expert STagINg and carE DESTINE study group, a Ventricular Assist Device Driveline Infection Study Group. Prevention and early treatment of driveline infections in ventricular assist device patients - the DESTINE staging proposal and the first standard of care protocol. J Crit Care 2020; 56: 106-112
    CrossrefPubMedSearch in Google Scholar
  • 57 Mehra MR, Uriel N, Naka Y. et al; MOMENTUM 3 Investigators. A fully magnetically levitated left ventricular assist device - final report. N Engl J Med 2019; 380 (17) 1618-1627
    CrossrefPubMedSearch in Google Scholar
  • 58 Siegenthaler MP, Martin J, Pernice K. et al. The Jarvik 2000 is associated with less infections than the HeartMate left ventricular assist device. Eur J Cardiothorac Surg 2003; 23 (05) 748-754 , discussion 754–755
    CrossrefPubMedSearch in Google Scholar
  • 59 Bejko J, Toto F, Gregori D, Gerosa G, Bottio T. Left ventricle assist devices and driveline's infection incidence: a single-centre experience. J Artif Organs 2018; 21 (01) 52-60
    CrossrefPubMedSearch in Google Scholar
  • 60 Zucchetta F, Tarzia V, Bottio T, Gerosa G. The Jarvik-2000 ventricular assist device implantation: how we do it. Ann Cardiothorac Surg 2014; 3 (05) 525-531
    PubMedSearch in Google Scholar
  • 61 Letsou GV, Anand J, Ogburn E. et al. Low incidence of pump-related infections in Jarvik 2000 ventricular assist device recipients with a subcostal driveline exit site. Tex Heart Inst J 2019; 46 (03) 179-182
    CrossrefPubMedSearch in Google Scholar
  • 62 Kusne S, Danziger-Isakov L, Mooney M. et al. Infection control and prevention practices for mechanical circulatory support: an international survey. J Heart Lung Transplant 2013; 32
    CrossrefPubMedSearch in Google Scholar
  • 63 Kallen AJ, Wilson CT, Larson RJ. Perioperative intranasal mupirocin for the prevention of surgical-site infections: systematic review of the literature and meta-analysis. Infect Control Hosp Epidemiol 2005; 26 (12) 916-922
    CrossrefPubMedSearch in Google Scholar
  • 64 Berríos-Torres SI, Umscheid CA, Bratzler DW. et al; Healthcare Infection Control Practices Advisory Committee. Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017. JAMA Surg 2017; 152 (08) 784-791
    Search in Google Scholar
  • 65 Yoshitake S, Kinoshita O, Nawata K. et al. Novel driveline route for prevention from driveline infection: triple tunnel method. J Cardiol 2018; 72 (04) 363-366
    CrossrefPubMedSearch in Google Scholar
  • 66 Cagliostro B, Levin AP, Fried J. et al. Continuous-flow left ventricular assist devices and usefulness of a standardized strategy to reduce drive-line infections. J Heart Lung Transplant 2016; 35 (01) 108-114
    CrossrefPubMedSearch in Google Scholar
  • 67 Sousa-Uva M, Head SJ, Milojevic M. et al. 2017 EACTS Guidelines on perioperative medication in adult cardiac surgery. Eur J Cardiothorac Surg 2018; 53 (01) 5-33
    CrossrefPubMedSearch in Google Scholar
  • 68 Maly J, Szarszoi O, Netuka I, Dorazilova Z, Pirk J. Fungal infections associated with long-term mechanical circulatory support-diagnosis and management. J Card Surg 2014; 29 (01) 95-100
    CrossrefPubMedSearch in Google Scholar
  • 69 Stulak JM, Maltais S, Cowger J. et al. Prevention of percutaneous driveline infection after left ventricular assist device implantation: prophylactic antibiotics are not necessary. ASAIO J 2013; 59 (06) 570-574
    CrossrefPubMedSearch in Google Scholar
  • 70 Nair PM, Salaita K, Petit RS, Groves JT. Using patterned supported lipid membranes to investigate the role of receptor organization in intercellular signaling. Nat Protoc 2011; 6 (04) 523-539
    CrossrefPubMedSearch in Google Scholar
  • 71 Yarboro LT, Bergin JD, Kennedy JLW. et al. Technique for minimizing and treating driveline infections. Ann Cardiothorac Surg 2014; 3 (06) 557-562
    PubMedSearch in Google Scholar
  • 72 Chinn R, Dembitsky W, Eaton L. et al. Multicenter experience: prevention and management of left ventricular assist device infections. ASAIO J 2005; 51 (04) 461-470
    CrossrefPubMedSearch in Google Scholar
  • 73 Wus L, Manning M, Entwistle III JW. Left ventricular assist device driveline infection and the frequency of dressing change in hospitalized patients. Heart Lung 2015; 44 (03) 225-229
    CrossrefPubMedSearch in Google Scholar
  • 74 Stahovich M, Sundareswaran KS, Fox S. et al. Reduce driveline trauma through stabilization and exit site management: 30 days feasibility results from the multicenter RESIST study. ASAIO J 2016; 62 (03) 240-245
    CrossrefPubMedSearch in Google Scholar
  • 75 Lander MM, Kunz N, Dunn E. et al. Substantial reduction in driveline infection rates with the modification of driveline dressing protocol. J Card Fail 2018; 24 (11) 746-752
    CrossrefPubMedSearch in Google Scholar
  • 76 Hieda M, Sata M, Seguchi O. et al. Importance of early appropriate intervention including antibiotics and wound care for device-related infection in patients with left ventricular assist device. Transplant Proc 2014; 46 (03) 907-910
    CrossrefPubMedSearch in Google Scholar
  • 77 Son AY, Stein LH, DeAnda A. et al. Impact of chlorhexidine gluconate intolerance on driveline infection during chronic HeartMate II left ventricular assist device support. Int J Artif Organs 2017; 39 (11) 570-574
    CrossrefPubMedSearch in Google Scholar
  • 78 Menon AK, Baranski SK, Unterkofler J. et al. Special treatment and wound care of the driveline exit site after left ventricular assist device implantation. Thorac Cardiovasc Surg 2015; 63 (08) 670-674
    Thieme ConnectPubMedSearch in Google Scholar
  • 79 Özdemir Z, Şenol Çelik S. Wound care of the driveline exit site in patients with a ventricular assist device: a systematic review. Turk Gogus Kalp Damar Cerrahisi Derg 2018; 26 (02) 328-335
    CrossrefPubMedSearch in Google Scholar
  • 80 Durand ML, Ennis SC, Baker JN. et al. Topical polymyxin-trimethoprim prophylaxis may decrease the incidence of driveline infections in patients with continuous-flow left ventricular assist devices. Artif Organs 2017; 41 (02) 169-175
    CrossrefPubMedSearch in Google Scholar
  • 81 Cannon A, Elliott T, Ballew C. et al. Variability in infection control measures for the percutaneous lead among programs implanting long-term ventricular assist devices in the United States. Prog Transplant 2012; 22 (04) 351-359
    CrossrefPubMedSearch in Google Scholar
  • 82 Smith EM, Franzwa J. Chronic outpatient management of patients with a left ventricular assist device. J Thorac Dis 2015; 7 (12) 2112-2124
    PubMedSearch in Google Scholar
  • 83 Aburjania N, Sherazi S, Tchantchaleishvili V, Alexis JD, Hay CM. Stopping conventional showering decreases Pseudomonas infections in left ventricular assist device patients. Int J Artif Organs 2017; 40 (06) 282-285
    CrossrefPubMedSearch in Google Scholar
  • 84 Kusne S, Staley L, Arabia F. Prevention and infection management in mechanical circulatory support device recipients. Clin Infect Dis 2017; 64 (02) 222-228
    CrossrefPubMedSearch in Google Scholar
  • 85 Hozayen SM, Soliman AM, Eckman PM. Comparison of two ventricular assist device dressing change protocols. J Heart Lung Transplant 2012; 31 (01) 108-109
    CrossrefPubMedSearch in Google Scholar
  • 86 Schlöglhofer T, Robson D, Bancroft J. et al. International coordinator survey results on the outpatient management of patients with the HeartWare® ventricular assist system. Int J Artif Organs 2017; 39 (11) 553-557
    CrossrefPubMedSearch in Google Scholar
  • 87 Puhlman MWL, Sullivan R. Weekly dressing protocol reduces the incidence of driveline infection. J Heart Lung Transplant 2015; •••
    CrossrefPubMedSearch in Google Scholar
  • 88 Barber J, Leslie G, Grad P. et al. A simple education tool for ventricular assist device patients and their caregivers. J Cardiovasc Nurs 2015; 30 (03) E1-E10
    CrossrefPubMedSearch in Google Scholar
  • 89 Itescu S, John R. Interactions between the recipient immune system and the left ventricular assist device surface: immunological and clinical implications. Ann Thorac Surg 2003; 75 (6, Suppl): S58-S65
    CrossrefPubMedSearch in Google Scholar
  • 90 Ankersmit HJ, Tugulea S, Spanier T. et al. Activation-induced T-cell death and immune dysfunction after implantation of left-ventricular assist device. Lancet 1999; 354 (9178): 550-555
    CrossrefPubMedSearch in Google Scholar
  • 91 Varr BC, Restaino SW, Farr M. et al. Infectious complications after cardiac transplantation in patients bridged with mechanical circulatory support devices versus medical therapy. J Heart Lung Transplant 2016; 35 (09) 1116-1123
    CrossrefPubMedSearch in Google Scholar
  • 92 Schaenman JM, Rossetti M, Korin Y. et al. T cell dysfunction and patient age are associated with poor outcomes after mechanical circulatory support device implantation. Hum Immunol 2018; 79 (04) 203-212
    CrossrefPubMedSearch in Google Scholar
  • 93 Carr CM, Jacob J, Park SJ, Karon BL, Williamson EE, Araoz PA. CT of left ventricular assist devices. Radiographics 2010; 30 (02) 429-444
    CrossrefPubMedSearch in Google Scholar
  • 94 Tlili G, Picard F, Pinaquy JB, Domingues-Dos-Santos P, Bordenave L. The usefulness of FDG PET/CT imaging in suspicion of LVAD infection. J Nucl Cardiol 2014; 21 (04) 845-848
    CrossrefPubMedSearch in Google Scholar
  • 95 Sommerlath Sohns JM, Kröhn H, Schöde A. et al. 18F-FDG PET/CT in Left-ventricular assist device infection: initial results supporting the usefulness of image-guided therapy. J Nucl Med 2020; 61 (07) 971-976
    CrossrefPubMedSearch in Google Scholar
  • 96 Kim J, Feller ED, Chen W, Liang Y, Dilsizian V. FDG PET/CT for early detection and localization of left ventricular assist device infection: impact on patient management and outcome. JACC Cardiovasc Imaging 2019; 12 (04) 722-729
    CrossrefPubMedSearch in Google Scholar
  • 97 Litzler PY, Manrique A, Etienne M. et al. Leukocyte SPECT/CT for detecting infection of left-ventricular-assist devices: preliminary results. J Nucl Med 2010; 51 (07) 1044-1048
    CrossrefPubMedSearch in Google Scholar
  • 98 Kimura Y, Seguchi O, Mochizuki H. et al. Role of gallium-SPECT-CT in the management of patients with ventricular assist device-specific percutaneous driveline infection. J Card Fail 2019; 25 (10) 795-802
    CrossrefPubMedSearch in Google Scholar
  • 99 Juneau D, Golfam M, Hazra S. et al. Positron emission tomography and single-photon emission computed tomography imaging in the diagnosis of cardiac implantable electronic device infection: a systematic review and meta-analysis. Circ Cardiovasc Imaging 2017; 10 (04) e005772
    CrossrefPubMedSearch in Google Scholar
  • 100 de Vaugelade C, Mesguich C, Nubret K. et al. Infections in patients using ventricular-assist devices: comparison of the diagnostic performance of 18F-FDG PET/CT scan and leucocyte-labeled scintigraphy. J Nucl Cardiol 2019; 26 (01) 42-55
    CrossrefPubMedSearch in Google Scholar
  • 101 Erba PA, Sollini M, Conti U. et al. Radiolabeled WBC scintigraphy in the diagnostic workup of patients with suspected device-related infections. JACC Cardiovasc Imaging 2013; 6 (10) 1075-1086
    CrossrefPubMedSearch in Google Scholar
  • 102 Toda K, Sawa Y. Clinical management for complications related to implantable LVAD use. Gen Thorac Cardiovasc Surg 2015; 63 (01) 1-7
    CrossrefPubMedSearch in Google Scholar
  • 103 Simon D, Fischer S, Grossman A. et al. Left ventricular assist device-related infection: treatment and outcome. Clin Infect Dis 2005; 40 (08) 1108-1115
    CrossrefPubMedSearch in Google Scholar
  • 104 Pereda D, Conte JV. Left ventricular assist device driveline infections. Cardiol Clin 2011; 29 (04) 515-527
    CrossrefPubMedSearch in Google Scholar
  • 105 Haddad E, Lescure FX, Ghodhbane W. et al. Left ventricular assist pump pocket infection: conservative treatment strategy for destination therapy candidates. Int J Artif Organs 2017; 40: 0
    CrossrefPubMedSearch in Google Scholar
  • 106 Pieri M, Scandroglio AM, Müller M. et al. Surgical management of driveline infections in patients with left ventricular assist devices. J Card Surg 2016; 31 (12) 765-771
    CrossrefPubMedSearch in Google Scholar
  • 107 Balsam LB, Jacoby A, Louie E, Levine JP. Long-term success with driveline exit site relocation for deep driveline infection in left ventricular assist device patients. Innovations (Phila) 2017; 12 (06) 440-445
    CrossrefPubMedSearch in Google Scholar
  • 108 Abicht T, Gordon R, Meehan K, Stosor V, McCarthy P, McGee Jr E. Complex HeartMate II infection treated with pump exchange to HeartWare HVAD. ASAIO J 2013; 59 (02) 188-192
    CrossrefPubMedSearch in Google Scholar
  • 109 Walter V, Stock UA, Soriano-Romero M, Schnitzbauer A, Moritz A, Beiras-Fernandez A. Eradication of a chronic wound and driveline infection after redo-LVAD implantation. J Cardiothorac Surg 2014; 9: 63
    CrossrefPubMedSearch in Google Scholar
  • 110 Bauer TM, Choi JH, Luc JGY. et al. Device exchange versus nonexchange modalities in left ventricular assist device-specific infections: a systematic review and meta-analysis. Artif Organs 2019; 43 (05) 448-457
    CrossrefPubMedSearch in Google Scholar
  • 111 Sperry BW, Fatemi O, Ruiz ME, Najjar SS. Late manifestation of a driveline infection after heart transplantation. J Heart Lung Transplant 2014; 33 (03) 324-325
    CrossrefPubMedSearch in Google Scholar
  • 112 Koval C. VAD infection during bridge-to-transplant, unique aspects of treatment and prevention. Curr Opin Organ Transplant 2018; 23 (04) 400-406
    CrossrefPubMedSearch in Google Scholar
  • 113 Tong MZ, Smedira NG, Soltesz EG. et al. Outcomes of heart transplant after left ventricular assist device specific and related infection. Ann Thorac Surg 2015; 100 (04) 1292-1297
    CrossrefPubMedSearch in Google Scholar
  • 114 Keenan JB, Rajab TK, Armstrong DG, Khalpey Z. Real-time autofluorescence imaging to diagnose LVAD driveline infections. Ann Thorac Surg 2017; 103 (06) e493-e495
    CrossrefPubMedSearch in Google Scholar
  • 115 Sezai A, Unosawa S, Taoka M. et al. New treatment for driveline infection following implantation of a ventricular assist device. Heart Surg Forum 2020; 23 (02) E132-E134
    CrossrefPubMedSearch in Google Scholar
  • 116 Saji M, Taguchi S, Hayama N. et al. Effect of gentian violet on the elimination of methicillin-resistant Staphylococcus aureus (MRSA) existing in the decubitus region [in Japanese]. Nippon Ronen Igakkai Zasshi 1993; 30 (09) 795-801
    CrossrefPubMedSearch in Google Scholar
  • 117 Maley AM, Arbiser JL. Gentian violet: a 19th century drug re-emerges in the 21st century. Exp Dermatol 2013; 22 (12) 775-780
    CrossrefPubMedSearch in Google Scholar
  • 118 Formica F, Perseghin P, Cirò A, Paolini G. Late driveline left ventricular assist device infection treated with frozen-and-thawed allogeneic platelet gel. Interact Cardiovasc Thorac Surg 2014; 19 (03) 523-525
    CrossrefPubMedSearch in Google Scholar
  • 119 Jiritano F, Serraino GF, Rossi M, Dominijanni A, Brescia A, Renzulli A. Ventricular assist device driveline infection: treatment with platelet-rich plasma. Ann Thorac Surg 2013; 96 (02) e37-e38
    CrossrefPubMedSearch in Google Scholar
  • 120 Perseghin P, Sciorelli G, Belotti D. et al. Frozen-and-thawed allogeneic platelet gels for treating postoperative chronic wounds. Transfusion 2005; 45 (09) 1544-1546
    CrossrefPubMedSearch in Google Scholar
  • 121 Bielecki TM, Gazdzik TS, Arendt J, Szczepanski T, Król W, Wielkoszynski T. Antibacterial effect of autologous platelet gel enriched with growth factors and other active substances: an in vitro study. J Bone Joint Surg Br 2007; 89 (03) 417-420
    CrossrefPubMedSearch in Google Scholar
  • 122 Hilker L, von Woedtke T, Weltmann KD, Wollert HG. Cold atmospheric plasma: a new tool for the treatment of superficial driveline infections. Eur J Cardiothorac Surg 2017; 51 (01) 186-187
    CrossrefPubMedSearch in Google Scholar
  • 123 Haertel B, von Woedtke T, Weltmann KD, Lindequist U. Non-thermal atmospheric-pressure plasma possible application in wound healing. Biomol Ther (Seoul) 2014; 22 (06) 477-490
    CrossrefPubMedSearch in Google Scholar
  • 124 Haddad O, Pham AN, Thomas M. et al. Absorbable antibiotic beads as an adjuvant therapy in treating ventricular assist devices driveline infection: a case report. J Card Surg 2020; 35 (08) 2073-2076
    CrossrefPubMedSearch in Google Scholar
  • 125 Kilo J, Dumfarth J, Höfer D, Grimm M. Successful treatment of driveline infection with vacuum-assisted closure therapy and instillation therapy. Thorac Cardiovasc Surg Rep 2020; 9 (01) e29-e32
    Thieme ConnectPubMedSearch in Google Scholar
  • 126 Orwig D, Logue C, Hendriksen S. et al. An approach to treating a patient with a HeartMate II left ventricular assist device in a multiplace hyperbaric chamber: a case report. Undersea Hyperb Med. 2018; 45: 89-93
    PubMedSearch in Google Scholar
  • 127 Kot J, Siondalski P, Lenkiewicz E. The hyperbaric protective tube: a housing for a left ventricular assist device (LVAD) in a multiplace hyperbaric chamber. Diving Hyperb Med 2019; 49 (02) 137-140
    CrossrefPubMedSearch in Google Scholar
  • 128 Waters BH, Park J, Bouwmeester JC. et al. Electrical power to run ventricular assist devices using the Free-range Resonant Electrical Energy Delivery system. J Heart Lung Transplant 2018; 37 (12) 1467-1474
    CrossrefPubMedSearch in Google Scholar
  • 129 Wang JX, Smith JR, Bonde P. Energy transmission and power sources for mechanical circulatory support devices to achieve total implantability. Ann Thorac Surg 2014; 97 (04) 1467-1474
    CrossrefPubMedSearch in Google Scholar
  • 130 Pya Y, Maly J, Bekbossynova M. et al. First human use of a wireless coplanar energy transfer coupled with a continuous-flow left ventricular assist device. J Heart Lung Transplant 2019; 38 (04) 339-343
    CrossrefPubMedSearch in Google Scholar